Acetone health effects

Toxicity and health effects Acetone on inhalation causes irritation to nose, throat, lung, and eyes and headaches. Repeated exposure causes lightheadedness, confusion, increased pulse rate, nausea, vomiting, unconsciousness, and possibly coma. It also shortens the menstrual cycle in women. Laboratory animals after a prolonged exposure to acetone developed kidney, liver, and nerve damage and experienced increased birth defects and reproductive disturbances. ... 

The primary safety concern about acetone is its extreme flammability. Workers who handle the compound must use great care to prevent its coming into contact or even being in the vicinity of open flames. Under the proper conditions, acetone is also explosive. Exposure of the skin, eyes, and respiratory system to acetone may produce mild symptoms, such as dizziness, headaches, and disorientation and irritation of the eyes and skin. Such conditions are rare, however, and no long-term health effects of the compound have as yet been discovered. 

Ail CLA supplements currently offered contain approximately equal amounts of 9-cis,ll-trans and l0-trans,l2-cis. The extra costs of producing a biased isomer product might be justified if beneficial health effects were documented. The 9-cis,ll-trans and the l0-trans,l2-cis isomers of CLA are now available for research purposes in kilogram scale with a purity of -90%. In small quantities, purities up to 99% are offered. High yields and high purity can be obtained by repeated crys-talhzation of the methyl ester forms in acetone at temperatures as low as -60°C (22). 

Two molecules of phenol are used for each mole of acetone. Because phenol and acetone are produced in a 1 1 molar ratio and consumed in a 2 1 molar ratio, there is an excess of acetone. Therefore acetone is often a glut on the market and is a generally inexpensive solvent. The BPA is used to make various polymers, including polycarbonate, many epoxy resins, and some phenolic resins. BPA is used in many polymers that have food contact and BPA can be present in minute amounts. Examples of these applications include some plastic containers, bottles, and can Unings. Therefore, there is some concern about possible health effects. It continues to be a matter of study, but one review of the research suggests that current exposure levels are safe [14]. Phenol is also used to make phenol resins and as a feedstock in the manufacture of caprolactam, the monomer for nylon 6. 

Acetone is known to have the following health effects ... 

In addition to direct health effects, acetone has the following safety properties ... 

Zhao WY, Misumi J, Yasui T, et al. 1998. Effects of methyl ethyl ketone, acetone, or toluene coadministration on 2,5-hexanedione concentration in the sciatic nerve, serum, and urine of rats. Int Arch Occup Environ Health 71 236-244. 

Acetone is considered to be of low risk to health because few adverse effects have been reported despite widespread use for many years. One early study, often quoted, reports eye, nose, and throat irritation in volunteers exposed to 500 ppm. ... 

Industrial poisoning. The production of silicone products uses substances harmful for human health. These are inorganic substances (ammonia, chlorine, sodium and potassium hydroxides, sulfuric and hydrochloric acids, hydrogen chloride) and organic compounds of various types, such as hydrocarbons (methane, benzene and its homologues), chlorine derivatives (methyl- and ethylchloride, chlorobenzene), alcohols (methyl, ethyl, n-butyl, hydrosite), acetone, pyridine, etc. The information about their toxicity, explosion hazard, effect on human body, as well as maximum allowable concentrations of gases and vapours in the air at workplace can be found in special references.(Ryabov 1970). A comprehensive description of silicone substances is given in Table 29. 

Abstract. The distribution of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in the environment has not been systematically studied in Bulgaria in spite of their negative effect on the human health. The aim of this study is to develop a cost-effective method for determination of low concentrations of PCBs and OCPs in soils. After extraction with hexane/acetone and column cleaning with silica, the analyses was performed by gas chromatography with electron-capture detector. The limit of detection is between 0.1 and 1 ng g 1, the reproducibility at low environmental levels is about 15% RSD. The analytical recoveries for the individual compounds are between 65% and 100%. The method can be applied to study the sources of pollution, the migration and biogeochemistry of PCBs in the environment. 

Exposure to the vapors of acetyl acetone can cause irritation of the eyes, mncons membrane, and skin. In rabbits 4.76 mg produced severe eye irritation the effect on skin was mild. Other than these, the health hazards from this compound have not been reported. However, based on its stmcture and the fact that it has two reactive carbonyl gronps in the molecule, this compound shonld exhibit low to moderate toxicity at high concentrations, which should be greater than that of the C5-monoketones. 

Ciassification Member of the Vitamin B complex Empiricai C19H19N7O6 Properties Orange-yel. need, or platelets, odorless sol. in dil. alkali hydroxide, carbonate sol ns. si. sol. in water insol. in lipid soivs., acetone, alcohol, ether m.w. 441.45 Toxicoiogy LD50 (oral, mouse) 10 g/kg, (IP, mouse) 85 mg/kg, (IV, rat) 500 mg/kg LDLo (subcut., mouse) 200 mg/kg poison by IP and IV routes experimental teratogen, reproductive effects mutagenic data TSCA listed Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of NOx HMiS Health 1, Flammability 1, Reactivity 0 Uses Biological additive, skin conditioner in... 

Rapeseed phenolics isolated by Vuorela et al. (2004) were tested for radical scavenging and for liposome and low-density lipoprotein (LDL) model systems. The inhibition of hexanal and conjugated diene hydroperoxides formation was reported (>90% and >80%, respectively). All isolates also exhibited inhibition of LDL particles oxidation by >90%. The antioxidant activity of methanol and acetone extracts of canola hulls in a P-carotene-linoleate model system was comparable to that displayed by butylated hydroxyanisole (Naczk et al., 2005). These extracts showed more than 95% scavenging effects (at 40 p/assay on DPPH radical). Vuorela et al. (2005a,b) indicated that rapeseed phenolics were excellent antioxidants towards oxidation of phosphatidylcholine membrane (liposomes) and rapeseed oil (crude) phenolics were effective radical scavengers (DPPH test). The authors suggested that these phenolic isolates from rapeseed are safe and bioactive for possible food applications including functional foods intended for health benefit. 

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