Damage nerve

Nerves are rarely damaged during the total joint replacement surgery. However, nerve damage can occur if considerable joint deformity must be corrected in order to implant the prosthesis. With time these nerves sometimes return to normal function. 

Cyanide (as free cyanide) 0.2 0.2 Nerve damage or thyroid problems Discharge from steel/metal factories discharge from plastic and fertilizer factories... 

Adverse reactions associated with administration of the corticosteroid ophthalmic preparations include elevated IOP with optic nerve damage, loss of visual acuity, cataract formation, delayed wound healing, secondary ocular infection, exacerbation of comeal infections, dry eyes, ptosis, blurred vision, discharge, ocular pain, foreign body sensation, and pruritus. 

B, Thiamin Coenzyme in pyruvate and a-ketoglutarate, dehydrogenases, and transketolase poorly defined function in nerve conduction Peripheral nerve damage (beriberi) or central nervous system lesions (Wernicke-Korsakoff syndrome)... 

Folate supplements will rectify the megaloblastic anemia of vitamin Bj2 deficiency but may hasten the development of the (irreversible) nerve damage found in B,2 deficiency. There is also antagonism between fohc acid and the anticonvulsants used in the treatment of epilepsy. 

Acute exposure to trichloroethylene and its decomposition products (e.g., dichloroacetylene) has also led to residual neuropathy, characterized by nerve damage. This neuropathy is characterized by facial numbness, jaw weakness, and facial discomfort (indicating damage to cranial nerves V and VII) which can persist for several months (Buxton and Hayward 1967 Feldman 1970). Chronic exposure in the workplace has also been associated with damage to the cranial nerves in several cases (Bardodej and Vyskocil 1956 Barret et al. 1987 Cavanagh and Buxton 1989). Persons who have died from overexposure have shown degeneration of cranial nuclei in the brain stem (Buxton and Hayward 1967). Some of these effects may be attributed to... 

The arrival of action potentials in the dorsal horn of the spinal cord, carrying the sensory information either from nociceptors in inflammation or generated both from nociceptors and intrinsically after nerve damage, produces a complex response to pain. Densely packed neurons, containing most of the channels, transmitters and receptors found anywhere in the CNS, are present in the zones where the C-fibres terminate... 

Complete C-fibre inhibitions can be produced under normal conditions but opiates do not always produce a complete analgesia in some clinical situations, especially when the pain arises from nerve damage. Reasons for this are suspected to be excessive NMDA-mediated activity which is hard to inhibit and the mobilisation of cholecysto-kinin in the spinal cord which can act as a physiological antagonist of opiate actions. The idea that pre-emptive analgesia aids post-operative pain relief by preventing the pain-induced activation of these systems is becoming popular. 

Wirsig C.R. and Leonard C.M. (1987). Terminal nerve damage impairs the mating behavior of the male hamster. Brain Res 417, 293-303. 

The goals of therapy are to prevent further loss of visual function minimize adverse effects of therapy and its impact on the patient s vision, general health, and quality of life control intraocular pressure in order to reduce or prevent further optic nerve damage and educate and involve the patient in the management of their disease. 

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