Acetate acid diethyl ester

The reduction of o-nitrophenyl acetic acids or esters leads to cyclization to oxindoles. Several routes to o-nitrophenylacetic acid derivatives arc available, including nitroarylation of carbanions with o-nitroaryl halides[2l,22] or trif-late[23] and acylation of o-nitrotoluenes with diethyl oxalate followed by oxidation of the resulting 3-(u-nitrophenyl)pyruvate[24 26]. 

C,Hj04 2613-89-0) see Carfecillin Carindacillin phenylmalonic acid benzyl ester chloride (Ci Hi ClO 35353-13-0) see Carbenicillin phenylmalonic acid diethyl ester see under diethyl phenylmalonate phenylmcrcuric acetate... 

Acetic acid, methyl ester Acetic acid, ethyl ester Pentanoic acid, methylethyl ester Acetic acid, methylethyl ester Acetic acid, 3-propenyl ester Acetic acid, benzyl ester Oxalic acid, dimethyl ester Oxalic acid, diethyl ester Oxalic acid, fe(l-methylethyl) ester... 

Acetic acid, butyl ester Acetic acid, pentyl ester Acetic acid, decyl ester Acetic acid, benzyl ester Acetic acid, benzyl ester Acetic acid, 1-cyclohexenyl ester Acetic acid, 3-cyclohexenyl ester Butyric acid, benzyl ester Phenylacetic acid, propyl ester Oleic acid, methyl ester Linoleic acid, methyl ester Linolenic acid, methyl ester Adipic acid, methyl ester Adipic acid, ethyl ester Adipic acid, diethyl ester Adipic acid, dipropyl ester Adipic acid, (methylethyl)ester Adipic acid,... 

PSVBDEP poly(styrene-co-4-vinyl benzene phosphonic acid diethyl ester) PVAc poly(vinyl acetate)... 

OB to C02 —65.37% v hygr prisms (from acetic acid + benz) mp 87.5°. V sol in acetic acid si sol in benz insol in petr eth. Prepn is by heating bromomethylmalonic acid diethyl ester with Na azide dissolved in aq ethanol. Its Ag salt, Silver Azido-iso-Succinic Acid, color cryst, deton violently on heating (Refs 1, [272]... 

In a study NSAIDs indomethacin (2-[l-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetic acid), acemetacin (l-[p-chlorobenzoyl]-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester), and etodolac (( )-l,8-diethyl-l,3,4,9-tetrahydropyrano-(3,4-b)indole-l-acetic acid) were tested on different ROS generating systems (Fig. 1). There are some satisfactory results that confirm that the anti-inflammatory activity of these compounds may be also partly due to their ability to scavenge ROS and RNS. The observed effective scavenging activity may contribute to the anti-inflammatory therapeutical effects [92,100]. 

An aqueous solution of sodium nitrite that is treated with HC1 contains nitrosyl cations 0=N . These can react with the enol E of the malonic acid diethyl ester (cf. Figure 12.9, bottom). First, a nitroso compound (F) is formed, which then undergoes acid-catalyzed isomerization to give the oxime A. Usually, the oxime is reduced by zinc, which is dissolved in acetic acid, to yield an amine that normally undergoes in situ acetylation in acetic acid. In this way the (acetamido)malonic acid diethyl ester B is obtained as the reduction/acetylation product, which can be employed, for example, in the synthesis of amino acids (Figure 13.39). 

Figure 13.39 shows that malonic ester syntheses can also lead to acetic acid derivatives with a heteroatom in the a-position. The benzylation of (acetamido)malonic acid diethyl ester... 

The malonic ester synthesis makes substituted derivatives of acetic acid. Malonic ester (diethyl malonate) is alkylated or acylated on the more acidic carbon that is a to both carbonyl groups, and the resulting derivative is hydrolyzed and allowed to decarboxylate. 

A wide variety of substituted y-butyrolactones can be prepared directly from olefins and aliphatic carboxylic acids by treatment with manganic acetate. This procedure is illustrated in the preparation of 7-( -OCTYL)-y-BUTYROLACTONE. Methods for the synthesis of chiral molecules are presently the target of intensive investigation. One such general method developed recently is the employment of certain chiral solvents as auxiliary agents in asymmetric synthesis. The preparation of (S.SM+H, 4-BIS(DIMETHYLAMINO)-2,3-DIMETHOXY-BUTANE FROM TARTARIC ACID DIETHYL ESTER provides a detailed procedure for the production of this useful chiral media an example of its utility in the synthesis of (+)-(/ )-l-PHENYL-l-PEN-TANOL from benzaldehyde and butyllithium is provided. 

DICHLORO-PHENOL-O-ESTER with 0,0-DIETHYL PHOSPHOROTHIOATE see DFK600 (2,4-DICHLOROPHENOXY)ACETIC ACID, ISOPROPYL ESTER see lOYOOO (2-4-DICHLOROPHENOXY)ACETIC ACID-1-METHYLETHYL ESTER (9CI) see lOYOOO... 

OXALIC ACID, DIETHYL ESTER (95-92-1) Combustible liquid (flash point 168°F/ 76°C). Water slowly forms oxalic acid. Incompatible with zinc acetate. Violent reaction with strong oxidizers. 

U112. . Acetic acid, ethyl ester (I) U088. . 1,2 Benzenedicarboxylic acid, diethyl... 

R = H), derived from (+)-oxopinic acid, and (aminomethyl)phosphonic acid diethyl ester, was alkylated in the usual way and the products hydrolysed to give the (S)-( 1-aminoalkyl)phosphonic diesters with 15. 62, 93, and 92% e.e. for R = Me, Et. Bn. and allyl. The reaction between (347 R = Li) and diethyl vinylphosphonate gave the (lS)-(347 R = CH2CH2P02Et2) which was acidolysed ( aqueous acetic acid) to... 

C]benzyl alcohol [7- " C]benzyl chloride [l- Clphenyl acetic acid ethyl ester [2- " C]phenyl malonic acid diethyl ester... 

To a suspension of 1.31 g A-acetyl-D,L-alanine (10 mmol) in 10 mL acetic anhydride was added 3.2 mL diethyl acetylenedicarboxylate (20 mmol). The reaction mixture was maintained at 110°C for 2 h, cooled, and then evaporated under reduced pressure. The oily residue was dissolved in hot cyclohexane and left in the refrigerator overnight with crystal seeds. Diethyl 2,5-dimethyl pyrrole-3,4-dicarboxylate was isolated as white needles by filtration, in amount of 274 mg, in a yield of 11.4%. The filtrate was evaporated and chromatographed (dry column vacuum chromatography) using CH2CI2 and then CH2Cl2/EtOH (99 1 to 98 2) to afford 1.58 g 2-(2,5-dimethyl-3,4-diethoxycarbonyl)-pyrrolyl maleic acid diethyl ester as a yellowish oil, in a yield of 39%. 

Dicaprylyl ether. See Dioctyl ether Dicaprylyl maleate (INCI). See Dioctyl maleate Dicaprylyl peroxide. See Dioctanoyl peroxide Dicaptol. See 2,3-Dimercapto-1-propanol Dicarbamoylhydrazine. See Biurea S-(1,2-Dicarbethoxyethyl)-0,0-dimethyldithiophosphate. See Malathion Dicarbethoxymethane. See Diethyl malonate P,P-Dicarbomethoxydiethyl sulfide. See Dimethyl thiodipropionate Dicarbomethoxy zinc. See Zinc acetate Dicarbonic acid, diethyl ester. See Diethyl... 

Sodium acid methanearsonate Methane base. See Bis (p-dimethylaminophenyl) methane Methane, bis (2-(2-butoxyethoxy) ethoxy)-. See Butylcarbitol formal Methanebis (N,N -(5-ureido-2,4-diketotetrahydroimidazole)-N,N-dimethylol). See Imidazolidinyl urea Methane, bromochloro-. See Bromochloromethane Methane, bromochlorodifluoro-. See Bromochlorodifluoroemethane Methane, bromodichloro-. See Bromodichloromethane Methane, bromotrifluoro. See Trifluorobromomethane Methanecarbonitrile. See Acetonitrile Methanecarboxamide. See Acetamide Methanecarboxylic acid. See Acetic acid Methane, chloro-. See Methyl chloride Methane, chlorodibromo-. See Chlorodibromomethane Methane, chlorofluoro-. See Chlorofluoromethane Methane, compressed. See Methane gas, Methane cyanine. See Malononitrile Methane, diazo-. See Diazomethane Methanedicarbonic acid Methanedicarboxylic acid. See,Malonic acid Methanedicarboxylic acid, diethyl ester. See Diethyl malonate... 

To a flame-dried test tube equipped with a magnetic stirring bar was added 2-(2,3-pentadienyl)-2-(3-trimethylsilanyl-2-propynyl)malonic acid diethyl ester (477a, 41 mg, 0.13 mmol) and toluene (0.5 mL). The test tube was evacuated and charged with N2 (this step was repeated 3 times) and [Rh(CO)2Cl]2 (2.5 mg, 6 x 10" mmol) was added. The mixture was stirred at room temperature for 1 h under N2 atmosphere (1 atm). The solvent was removed in vacuo and the residue was purified by flash chromatography (Si02, hexanesrethyl acetate=9 l) to afford 478a as a colorless oil (18.3 mg, 45%). ... 

This acetylpyridone diester 15 was conveniently synthesized in 60% yield by reacting acetoacetamide with ethoxy-methylene oxalacetic acid diethyl ester 14 in ethanol in the presence of sodium acetate (13). Compound 14 was prepared according to the procedure of R. G. Jones by condensing ethyl oxalacetate with ethyl orthoformate in the presence of acetic anhydride (14). It was found that purified compound 14 gave the best yield (60%) of acetylpyridone diester 15, but as a matter of convenience, crude 14 gave product 15 in up to 40% yield. Isolation of 15 was expedited by the precipitation of its sodium salt from the reaction mixture. 

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