PHOSPHONIC ACID .-, DIETHYL ESTER

CN [l-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]ethyl]phosphonic acid diethyl ester... 

Diethyl phosphite Phosphonic acid, diethyl ester (762-04-9), 75, 23... 

Phosphonic acid, (aminomethyl), diethyl ester, 65, 119 Phosphonic acid, (diazomethyl)-, dimethyl ester, 55, 119 Phosphonic acid, diethyl ester (752-04-9), 66, 202... 

PSVBDEP poly(styrene-co-4-vinyl benzene phosphonic acid diethyl ester) PVAc poly(vinyl acetate)... 

The Synthesis of (S)-[l-(Acetoxyl)-4-(3-Phenyl)Butyl]Phosphonic Acid Diethyl Ester (Anticholesterol Drug)... 

S)-[l-(acetoxyl)-4-(3-phenyl)butyl]phosphonic acid diethyl ester (10) is a key intermediate required for the synthesis of (11) (Scheme 7.6), which is being... 

Reaction of 4-aryl-7-iodoperhydropyrido]2,l-c][l,4]oxazin-6-ones (07USA2007/0117839, 08WOP2008/013213) and 7-iodo-6-oxo-4-(3,4,5-tri-fluorophenyl)perhydropyrido[2,l-a]pyrazine-2-carboxylate (07USA2007/ 0117839) with P(OEt)3 at 120 °C for 2 h afforded 7-phosphonic acid diethyl esters. 3-Hydroxy-6-arylperhydropyrido[2,l-c][l,4]oxazin-4-ones first were reacted with triphenylphosphonium bromide in refluxing MeCN, then with 3-methoxy-4-(4-methyl-lH-imidazol-l-yl)benzaldehyde at ambient temperature in the presence of NEt3 to provide (Z)-3- l-[3-methoxy-4-(4-methyl-lH-imidazol-l-yl)phenyl]methylidene] derivatives (07USA2007/ 0117798, 08USA2008 /0207900). 

RN Patel, A Baneijee, LJ Szarka. Stereoselective acetylation of [l-(hydroxy)-4-(3-phenoxyphenyl)butyl]phosphonic acid diethyl ester. Tetrahedron Asymmetry 8 1055-1059, 1997. 

Toluene-(4-sulfomethyl)phosphonic acid diethyl ester Hydrogen chloride Trimethylsilyl bromide Ammonium hydroxide... 

By the alkylation of N-benzoyl uracil with the chiral 2-trityloxy-oxirane was obtained glycoside-like derivative N-[l-(2-hydroxy-3-trityloxy-propyl)-2-oxo-l,2-dihydroxypyrimidin-4-yl]-N-methylbenzamide as a single isomer. From N-[1-(2-hydroxy-3-trityloxy-propyl)-2-oxo-l,2-dihydroxypyrimidin-4-yl]-N-methylbenzamide and toluene-(4-sulfomethyl)phosphonic acid diethyl ester was prepared [2-[(benzoylmethylamino)-2-oxo-2H-pyrimidin-l-yl]-l-trityloxymethylethoxymethyljphosphonic acid diethyl ester. As a result of... 

The synthesis of multidentate Lewis acids is of great interest [102]. The photostimulated reactions of [o-(diethoxy-phosphoryl)-phenyl]-phosphonic acid diethyl ester with Me3Sn- ions in liquid ammonia affords the disubstitution product 6>-Z f -trimethylstannanyl-benzene 29a in 67% yield [103]. Under the same experimental conditions, 2,2/-Zus(diethylphosphoxy)-1,1 -binaphthyl 30 affords the disubstitution product 31 in high yields (Sch. 28) [103]. 

Diethyl phosphite Phosphonic acid, diethyl ester (762-04-9), 75, 22 Diethyl sulfate Sulfuric acid, diethyl ester (64-67-5), 77, 153 Diethyl tartrate, 76, 93 Diethylzinc Zinc, diethyl- (557-20-0), 76, 89... 

PHONYL ALKENES Isocyanomethane-phosphonic acid diethyl ester. 

Last year s Report included mention of the synthesis of various -3-(and 2-)-carboxypiperidinylalkylphosphonic acids with biological activities similar to that referred to in the previous paragraph. More examples of such compounds have now been described their synthesis commenced with (4-pyridinylmethyl)phosphonic acid diethyl ester and developed with processes of chain extension,... 

Isocyanomethane-phosphonic acid diethyl ester, (C2H50)2P(0)CH2N=C (1). Mol. wt. 167.14. 

R = H), derived from (+)-oxopinic acid, and (aminomethyl)phosphonic acid diethyl ester, was alkylated in the usual way and the products hydrolysed to give the (S)-( 1-aminoalkyl)phosphonic diesters with 15. 62, 93, and 92% e.e. for R = Me, Et. Bn. and allyl. The reaction between (347 R = Li) and diethyl vinylphosphonate gave the (lS)-(347 R = CH2CH2P02Et2) which was acidolysed ( aqueous acetic acid) to... 

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