Accidents evidence

The map of rhinovirus 1A raises the question as to which of the alternative cleavage pathways have functional significance and which are mere accidents. Evidence that the alternative cleavage modes are not mere pecularities of rhinovirus 1A, but are preserved in detail through evolution and therefore probably have functional significance,comes from comparative studies on the processing of polioviral protein. 

Part One The accident situation and system have to be analysed for safety factors using the four aspects defined in the accident tetrahedron - exposure, assets, hazards and system response to the initiation of an accident. Evidence may be presented in tabular form or referenced to specific reports. The assessment and review methods should be recorded (including duration and participants), as it is likely that the evidence compiled in each aspect, may not be of equal volume. Every accident situation should have contributions in each area, any absence should be viewed as falling short of completeness. 

One of the objectives in the management of entrance channels is to guarantee safety and operationally levels that minimize the risk of accidents as well as to optimize the use and exploitation of the infrastructure. In recent years the evaluation of both levels has become necessary for the following reasons (1) the constant increase of the size of the fleet (2) the increase of maritime traffic and the competitiveness between harbors (3) the high cost of construction and maintenance of the infrastructures and (4) the increasing social sensitivity toward the environmental impact caused by accidents. Evidence of this interest can be seen in the recent revisions in safety policy carried out by PIANC and USAGE. ... 

The initial work a board performs largely determines the outcome of the investigation. If the board is sloppy, the results could be inconclusive, incorrect, or even misleading. Crucial accident evidence and information could be lost forever, and it might become impossible to truly determine what happened even if a new board is formed. 

Step 2 Gathering evidence and information. Studying accident evidence and interviewing witnesses is the primary mode of gathering information. 

McCammmon 1 (2004) Heuristics traps in recreational avalanche accidents evidence and implications, vol 68. Avalanche News... 

The models you use to portray failures that lead to accidents, and the models you use to propagate their effects, are attempts to approximate reality. Models of accident sequences (although mathematically rigorous) cannot be demonstrated to be exact because you can never precisely identify all of the factors that contribute to an accident of interest. Likewise, most consequence models are at best correlations derived from limited experimental evidence. Even if the models are validated through field experiments for some specific situations, you can never validate them for all possibilities, and the question of model appropriateness will always exist. 

One of the origins of this view of error and accident causation is the theory of accident proneness, which tried to show that a small number of individuals were responsible for the majority of accidents. Despite a number of studies that have shown that there is little statistical evidence for this idea (see, e.g., Shaw and Sichel, 1971) the belief remains, particularly in traditional industries, that a relatively small number of individuals accoimt for the majority of accidents. Another element in the emphasis on individual responsibility has been the legal dimension in many major accident investigations, which has often been concerned with attributing blame to individuals from the point of view of determining compensation, rather than in identifying the possible system causes of error. 

The successes of the traditional approach have largely been obtained in the area of occupational safety, where statistical evidence is readily available concerning the incidence of injuries to individuals in areas such as tripping and falling accidents. Such accidents are amenable to behavior modification approaches because the behaviors that give rise to the accident are under the direct control of the individual and are easily predictable. In addition, the nature of the hazard is also usually predictable and hence the behavior required to avoid accidents can be specified explicitly. For example, entry to enclosed spaces, breaking-open process lines, and lifting heavy objects are known to be potentially hazardous activities for which safe methods of work... 

Having described the underlying philosophy of the traditional approach to accident prevention, we shall now discuss some of the specific methods that are used to implement it, namely motivational campaigns and disciplinary action and consider the evidence for their success. We shall also discuss another frequently employed strategy, the use of safety audits. 

Nearly all major disasters provide ample evidence of the failures of organizations to learn from their own or other organizations experience. In the case of Three Mile Island for example, a similar accident had occurred some months before at the similarly designed Davis Besse plant, but correct worker intervention had averted an accident. 

Emphasis for prevention will be on changing individual behavior by symbolic or tangible rewards based on statistical evidence from the data collection system. "Hard" performance indicators such as lost time incidents will therefore be preferred to "softer" data such as near-miss reports. Accident prevention will also emphasize motivational campaigns designed to enhance the awareness of hazards and adherence to rules. If a severe accident occurs, it is likely that disciplinary sanctions will be applied. 

The TSE model of causation that accidents are primarily due to individually controllable unsafe acts is unlikely to be modified over time. This is because very little evidence on the background and conditions which led up to an accident will be collected. The data collection strategy is therefore likely to remain static, since the data collected wiU, by definition, not contradict the underlying assumptions. 

Because of the emphasis on modeling accident causation, data collection systems based on the system-induced error approach are likely to modify their data collection strategies over time. Thus, as evidence accumulates that the existing causal categories are inadequate to accoimt for the accidents and near misses that are reported, the data collection philosophy will be modified, and a new accident causation model developed. This, in turn, will be modified on the basis of subsequent evidence. 

Improvements in safety and environmental performance will come only slowly. Major accidents are rare, even with poorly managed programs, and any reduction in these will be evident only after several years. Areas where early improvements might be expected are spill response and occupational injuries where improved processes should be effective soon after installation. Work place exposure and environmental emissions may improve over a period of several months. 

In the photochemical isomerization of isoxazoles, we have evidence for the presence of the azirine as the intermediate of this reaction. The azirine is stable and it is the actual first photoproduct of the reaction, as in the reaction of r-butylfuran derivatives. The fact that it is able to interconvert both photochemically and thermally into the oxazole could be an accident. In the case of 3,5-diphenylisoxazole, the cleavage of the O—N bond should be nearly concerted with N—C4 bond formation (8IBCJ1293) nevertheless, the formation of the biradical intermediate cannot be excluded. The results of calculations are in agreement with the formation of the azirine [9911(50)1115]. The excited singlet state can convert into a Dewar isomer or into the triplet state. The conversion into the triplet state is favored, allowing the formation of the biradical intermediate. The same results [99H(50)1115] were obtained using as substrate 3-phenyl-5-methylisoxazole (68ACR353) and... 

Costs associated with increased government regulation are also difficult to quantify. Public concern in response to chemical release accidents affects regulators and community policy groups. It is evident that the U.S. chemical industry is already spending large amounts of money to avoid accidents and to deal with their consequences when they occur these costs are borne in part by the consumers. Continued expenditures are likely as industry strives to achieve an "acceptable" level of public safety throughout all chemical industry operations. 

Mast cells are present in the normal human heart and even more abundant in diseased hearts [ 16-18,25,47]. Within heart tissue, mast cells he between myocytes and are in close contact with blood vessels. They are also found in the coronary adventitia and in the shoulder regions of coronary atheroma [20, 21], The density of cardiac mast cells is higher in patients with dilated and ischemic cardiomyopathy than in accident victims without cardiovascular diseases [25], Importantly, in some of these conditions there is in situ evidence of mast cell activation [16,34],... 

Hepatic Effects. There is some evidence for trichloroethylene-induced hepatic effects in humans. This evidence is primarily from case reports of persons accidently or intentionally exposed to relatively high levels. 

In terms of the two-phase system which comprises dispersions of solids in liquids, the minimum energy requirement is met if the total interfacial energy of the system has been minimized. If this requirement has been met, chemically, the fine state of subdivision is the most stable state, and the dispersion will thus avoid changing physically with time, except for the tendency to settle manifest by all dispersions whose phases have different densities. A suspension can be stable and yet undergo sedimentation, if a true equilibrium exists at the solid-liquid interface. If sedimentation were to be cited as evidence of instability, no dispersion would fit the requirements except by accident—e.g., if densities of the phases were identical, or if the dispersed particles were sufficiently small to be buoyed up by Brownian movement. 

Information on the excretion of americium after dermal exposure in humans or animals is extremely limited. Some qualitative information is available from an accidental exposure in which a worker received facial wounds from projectile debris and nitric acid during an explosion of a vessel containing 241 Am (McMurray 1983). The subject also inhaled 241Am released to the air as dust and nitric acid aerosols, which was evident from external chest measurements of internal radioactivity thus, excretion estimates reflect combined inhalation, dermal, and wound penetration exposures (Palmer et al. 1983). Measurements of cumulative fecal and urinary excretion of241 Am during the first years after the accident, and periodic measurements made from day 10 to 11 years post accident indicated a fecal urine excretion ratio of approximately 0.2-0.3, although the ratio was approximately 1 on day 3 post accident (Breitenstein and... 

I suppose that some ingenious minds will be able to find a way of accommodating the chemical-balance hypothesis to these data, but I suspect that the accommodation will require convoluted circumventions, like those used by the Flat Earth Society in their efforts to maintain their defunct theory in the face of photographic evidence from space. If depression can be equally affected by drugs that increase serotonin, drugs that decrease it and drugs that do not affect it at all, then the benefits of these drugs cannot be due to their specific chemical activity. And if the therapeutic benefits of antidepressants are not due to their chemical composition, then the widely proffered chemical-imbalance theory of depression is without foundation. It is an accident of history produced serendipitously by the placebo effect. 

A publication summarises all the then available technical evidence related to the Seveso accident, and recommends operational criteria to ensure safety in commercial processes to produce trichlorophenol [4], All the plant scale incidents were characterised [ 1 ] by the subsequent occurrence of chloracne arising from the extremely toxic and dermatitic compound 2,3,7,8-tetrachlorodibenzodioxin (structure IX, p. S-3), formed dining the thermal runaway reaction and dispersed in the ensuing explosion. It is also extremely resistant to normal chemical decontamination procedures, and after the 1968 explosion, further cases occurred after transient contact with plant... 

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