Wool alcohols ointment

Synonyms Argobase EU wool alcohols ointment. Appearance white-colored ointment if prepared using white petrolatum, a yellow-colored ointment if yellow petrolatum is used in its preparation. 

Comments the BP 2004 describes lanolin alcohols ointment (wool alcohols ointment BP) as a mixture consisting of ... 

Features Active therapeutic ingreds. may be dissolved in either the oil or water phase or physically dispersed as a suspension in the emulsion Reguiatory Meets BP specs, tor wool alcohols ointment Properties Pale yel. soft solid, pract. odorless mostly sol. in min. oil, IPM partly sol. in acetone, anhyd. ethanol and IPA insol. in water m.p. 39-45 C HLB 4.0 acid no. 0.25 max. flash pt. > 100 C 6% cone. 

Uses W/o emulsifier, absorp. base for pharmaceutical ointments, w/o creams at low levels as HLB adjuster and stabilizer for o/w emulsions emollient Regulatory Improved version of wool alcohols ointment for the Gennan Phannaco-... 

White soft paraffin and wool fat are commonly used excipients for w/o emulsifying ointments. Emulsifying Hydrophobic Base Gel DAC (Table 12.26) is an ointment base free of wool fat and wool alcohols. It consists of plastibase (also named as Hydrophobic Base Gel DAC [43] polyethylene processed with liquid paraffines), isopropyl palmitate and triglycerol diisostearate. 

Ointment of Salicylic Acid, B,P. 2 per cent salicylic acid in ointment of wool alcohols. 

A somewhat empirical, but reasonably accurate, estimation of the salicylic acid can be obtained by direct titration of about 10 g of ointment in ether and ethanol with O IN alkali to phenol red. Deduct 0 10 per cent from the percentage obtained to allow for the acidity of the wool alcohols present in the ointment which titrate to phenol red. 

Unguentum Belladonnae Belladonna ointment, has the above extract 10%, diluted alcohol 5, benzoinated lard 65, and hydrous wool-fat, 20... 

Ointment bases do not seem to cause contact allergy in the anogenital region too often, despite wide use. Wool wax alcohol and amerchol L-101 are the most important (15,17). Contact sensitivity to balsam of Peru and fragrance mix is not infrequent and reflects the ubiquitous presence of these substances (16). 

Waxes are esters formed from long-chain (16 or more carbon atoms) fatty acids and long-chain alcohols. The general formula of a wax is the same as that of a simple ester, RGOOR, with the qualification that R and R are limited to alkyl groups with a large number of carbon atoms. Natural waxes are usually mixtures of several esters. Wax coatings on leaves help to protect the leaves from disease and also help the plant to conserve water. The feathers of birds are also coated with wax. Our ears are protected by wax. Several natural waxes have been used in consumer products. These include carnauba wax (from a Brazilian pahn tree), which is used in floor waxes, automobile waxes, and shoe polishes, and lanolin (from lamb s wool), which is used in cosmetics and ointments. Lanolin also contains cholesterol. 

Lanolin, wool fat, wool wax the fatty or more correctly waxy substance secreted by the skin of the sheep, m-p. 36-42°C. L constitutes up to 50% of the wei t of raw wool. It is a complicated mixture of fatty adds, alcohols, fats and waxy substances. The latter are chiefly esters of steroids (cholesterol and lanoster-ol) and long chain aliphatic alcohols with higher fatty acids, which are 6-hydroxylated or carry a terminal isopropyl or isobutyl residue. L. is obtained from raw wool by extraction with organic solvents or soap solutions. It forms water-in-oil suspensions, and is used widely in the pharmaceutical and cosmetics industries (as Adeps Lanae) as an ointment base. 

Wool fat or cholesterol in an eye ointment emulsify with lachrymal fluid resulting in a water-in-oil emulsion-type cream. Cetosteaiyl alcohol is not a muco- or bioadhesive substance. 

Wool fat (Adeps lanae this is a wax and not a fat) is used in ointments and in eye ointments and increases the penetration ability of lipophilic ointments. A drawback is the chance of contact allergy. Due to the presence of free surface active lanolin alcohols Wool fat has a greater power to absorb water than flie other waxes. Lanolin (Adeps lanae cum aqua) is an emulsion of 25 %water in 75 % Wool fat. 

The determination of the amount of unsaponifiable matter (which includes insoluble alcohols) is a useful figure for calculations on ointments containing wool fat. The most suitable method is that employing light... 

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