Unique sample identifier

When a sample arrives from a client it should immediately be assigned a unique sample identifier, often the next number in a defined sequence. This number should be attached to the sample and used by all the stalFconcerned. It must also be recorded either manually or electronically in a sample register. 

All application verification and soil samples must be individually labeled with unique sample identification (ID) and other identifying information such as study ID, test substance name, sample depth, replicate, subplot and date of collection, as appropriate. Proper study documentation requires that sample lists and labels be created prior to work commencing in the field. Water- and tear-resistant labels should be used since standard paper labels may become water-soaked and easily torn during sample handling. Sample lists should have the same information on them as the labels and are a convenient place to record plot randomization, initials of the individual who collected the sample, and date of collection. As such, the sample list is important in establishing chain of custody from the point of sample collection until its arrival at the laboratory. 

Reverse phase arrays differ substantially from forward phase capture arrays (otherwise known as antibody arrays) because protein lysate itself is printed on the array as bait used to capture the specific antibody, rather than printing the antibody first to capture the protein from solution. Therefore, many hundreds of samples can be printed on the same RPMA, and hundreds of parallel or identical arrays can be printed at once using advanced robotics. Each RPMA containing the multiple samples, identifiable by their geographic location, is incubated with a unique and specific detection antibody. 

Uniqueness checking and sample identifier generation Although different organizations have different rules of sample identifier generation, a... 

System makes sure all required data are entered (see Compound Registration Required and Optional Data Supplement). System performs uniqueness check against the database (see Uniqueness Check Business Rules Supplement). If the structure is unique, System registers the compound with a new sample identifier (see Sample Identifier Generation Rules Supplement). If it is not unique, System displays the compound to be registered and the hit compounds from uniqueness search and prompts die Chemist to resolve (see Resolve Compounds Use Case Spec). 

Chemical Laboratory Sample Identifier (LSI) An identifier that uniquely identifies a chemical sample. Although the format of sample identifier differs from organization to organization, it usually consists of five parts a prefix that specifies the sample s source (e.g., synthesized internally or acquired from external sources) a base that uniquely specifics parent structure a form that indicates whether a chemical sample is a free base or with salt, radiolabeled, or a formulation a parity bit checksum that is derived from the combination of prefix, base, and form using a check-sum hash algorithm and a batch or a lot number that identifies the actual physical sample. 

Registration Service Objects that are responsible for uniqueness checking, compound sample identifier generation, and persisting compound data into the chemical database. 

RegistrationService has two private methods uniquenessSearch(), which determines whether the structure of the compound to be registered is unique in the database and generateSampleIdentifier(), which according to the result of uniquenessSearch() generates the sample identifier. 

The collected samples must be identified with unique sample numbers efficiently tracked in the field stored in a secure location for the preservation of sample integrity and transferred to the laboratory with the information on their identification (ID) and the requested analysis. The provisions for sample numbering, labelling, storage in the field tracking and transfer to the laboratory are set forth in the SAP. 

Each collected sample must have its own unique identification number. The project staff will use this number to track the sample in the field and at the home office during the project assessment phase. The laboratory will use this number for matching the sample and the requested analysis. The laboratory will enter the field sample IDs into the data base and assign the samples with laboratory IDs for internal tracking. Analytical results will be reported for the samples identified according to their field and laboratory IDs. 

When a compound arrives at the compound management operation, the initial information must be verified and recorded in an inventory database. First, the sample must be associated with its container. This means a unique container identifier such as a barcode must be assigned to the sample. The container must carry the identifier throughout its lifecycle. Then initial data about the sample must be recorded. This includes the initial amount (weight for solid samples and volume for liquid solutions), concentration if in solution, container data such as barcode, type, and tare weight (if weighing will be part of the dispensing process). Submission creates or initiates the record of the container in the inventory. 

Waterproof labels attached to sample containers with waterproof adhesive are essential, as is the use of permanent ink to enter particulars on the label. Generally it is expedient to attach and write labels before placing the sample in the container, since difficulties can arise in attempting to write on wet or soiled labels. Sample labels should clearly identify the sample and any treatment it has received (for example, filtration). Each label should, as a minimum, include the name of the sampler, date and time of samphng, the exact location of the sampling point and any treatment and preservatives added and, to avoid risk of ambiguity, a unique sample number. 

In experiments in the biological sciences one generally cannot sample all state variables (compartments). In that case, some parameters of the system may not be uniquely determined (identifiable) by the observations of the experiment. In order to check identifiability, one need only examine... 

Chemometrics is multivariate data analysis or pattern recognition technique and can be used to interpret spectra without the identification and quantification of a number of individual compounds. The spectral patterns per se can be analyzed and compared with other spectra in order to evaluate similarities and differences between samples, identify unique mass numbers that make samples different, or track changes. Furthermore, the spectral patterns may be correlated to measured properties, for example, blend composition, by regression analysis. 

If some fields may be empty in the sublevels, all the fields in the main level are required for each entry. A new chiral separation record can be added in CHIRBASE solely if the authors correctly identify both sample and CSP. Since the beginning of the project, our policy has been to contact the authors of all publications containing incomplete, ambiguous or inconsistent data and to ask for additional information. Providing the separations with unique case numbers helps us considerably in this essential task, and also facilitates avoiding redundancies in the database. When chiral separations are reported for the second time in a new publication with exactly the same chromatographic conditions, this is stated in a footnote added in the field comments . In this field, miscellaneous information that cannot appear elsewhere are listed (detection limit, description of a reported chromatogram, racemization study, mobile phase limitations, etc.). 

Eisele and Tanner (146) have devised a similar scheme for the measurement of [HO ] via the chemical conversion of HO to H2 S04 by the addition of S02 to a flowing reactor followed by chemical ionization of gas-phase sulfuric acid to H S04 . The H 04 ion is uniquely identified and quantified in the flowing gas sample by a mass spectrometer. This technique is capable of sensitive, realtime measurement of [HO ], and although relatively new, appears to be perhaps the best overall technique devised to date. 

A system has been constructed which allows combined studies of reaction kinetics and catalyst surface properties. Key elements of the system are a computer-controlled pilot plant with a plug flow reactor coupled In series to a minireactor which Is connected, via a high vacuum sample transfer system, to a surface analysis Instrument equipped with XFS, AES, SAM, and SIMS. When Interesting kinetic data are observed, the reaction Is stopped and the test sample Is transferred from the mlnlreactor to the surface analysis chamber. Unique features and problem areas of this new approach will be discussed. The power of the system will be Illustrated with a study of surface chemical changes of a Cu0/Zn0/Al203 catalyst during activation and methanol synthesis. Metallic Cu was Identified by XFS as the only Cu surface site during methanol synthesis. 

Fresh oxamyl standards were prepared for each fortification event. Concentrations of 50 and 400 qg mL analytical-grade oxamyl were prepared in a 20% acetonitrile-80% FIPLC-grade water solution. The solutions were tranferred in 1-mL aliquots into uniquely identified vials so that each vial contained the correct volume of oxamyl standard to fortify one quality control sample. The vials were shipped as needed during the course of the study to each field site. 

SFE-GC is an attractive approach to coupling the extraction, concentration and chromatographic steps for the analysis of samples containing analytes that can be analysed using capillary GC. Often it is difficult to identify all the components which are extracted from samples by FID alone. This is a particular problem when the sample history and/or the identity of the compounds of interest are not known. When SFE-GC is combined to powerful spectroscopic detectors, unique data can be obtained, allowing their use as routine tools in the analytical laboratory. For positive identification of components of interest, multihyphenated techniques such as SFE-GC-AED, SFE-GC-MS, SFE-GC-FUR-MS are employed [46]. 

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