Undifferentiated type

J, NAA/Cr ratio in left medial TL of patients subjects with family history of schizophrenia showed greater deficit than subjects without history J, NAA/Cr ratio in left medial TL of patients J, NAA/Cr and Cho/Cr ratios in patients with disorganized and undifferentiated types of schizophrenia than with paranoid schizophrenia... 

Tumors identical to the undifferentiated type of NPC may originate in sites other than the nasopharynx, especially the sinonasal tract, oropharynx, larynx, and salivary gland. 777 JFgy afg distinguished from NPC only by location and observing the nasopharynx to be free of tumor. Likewise, the presence of EBV in a tumor is not unique to NPC. The virus has been found in a variety of histologically diverse tumors of the nasopharynx in patients from Southeast Asia. ... 

Undifferentiated type contains aspects of the other prominent types... 

Percentage of meteorites seen to fall. Chondrites. Over 90% of meteorites that are observed to fall out of the sky are classified as chondrites, samples that are distinguished from terrestrial rocks in many ways (3). One of the most fundamental is age. Like most meteorites, chondrites have formation ages close to 4.55 Gyr. Elemental composition is also a property that distinguishes chondrites from all other terrestrial and extraterrestrial samples. Chondrites basically have undifferentiated elemental compositions for most nonvolatile elements and match solar abundances except for moderately volatile elements. The most compositionaHy primitive chondrites are members of the type 1 carbonaceous (Cl) class. The analyses of the small number of existing samples of this rare class most closely match estimates of solar compositions (5) and in fact are primary source solar or cosmic abundances data for the elements that cannot be accurately determined by analysis of lines in the solar spectmm (Table 2). Table 2. Solar System Abundances of the Elements ... 

Tallent M, Dichter M, Bell GI, Reisine T. The cloned kappa opioid receptor couples to an N-type Ca++ current in undifferentiated PC 12 cells. Neuroscience 1994 63 1033-1040. 

The therapeutic application of stem cells has long been a dream of medical sciences, but recent discoveries and technical advances have brought this dream somewhat closer to being a reality. Stem cells are usually defined as undifferentiated cells capable of self-renewal that can differentiate into more than one specialized cell type. 

The main focus of stem cell research over the last few decades has been directed to embryonic stem cells. However, more recently, research upon and an understanding of various populations of adult stem cells has gathered pace. Adult stem cells are undifferentiated cells found amongst differentiated cells in a tissue or organ. These cells can renew themselves and can differentiate to yield the major cell types characteristic of the tissue in which they reside. The main physiological role of adult stem cells, therefore, appears to be to maintain and to repair (to a certain extent at least) the tissue in which they reside. 

The neural tube is a pseudostratified epithelium, with cells extending between the apical and basal surfaces of the epithelial wall. The neuroepithelium contains undifferentiated populations of stem cells and radial glia (see Ch. 29). With time, both of these cell types give rise to the three main lineages for neurons, astrocytes and oligodendrocytes. After the final mitotic division, neurons migrate away from the ventricular surface of the neural... 

Central nervous system stem cells maintain an undifferentiated state and the capacity to self-renew in response to epidermal growth factor and fibroblast growth factor 507 Cell lineage studies reveal close associations between distinct neural cell types 508... 

These cells are relatively undifferentiated and have a large nucleus, distinguishable nucleolus but few, if any, cytoplasmic granules. Myeloblasts arise from a precursor pool of stem cells, and both the rough endoplasmic reticulum and the Golgi apparatus stain for peroxidase, indicating that this enzyme is beginning to be synthesised. This cell type is capable of proliferation. 

The connection between DNA methylation and gene expression was first noticed when undifferentiated cells in culture were treated with the methylation inhibitor 5-azacytidine inhibition of methylation led to the appearance of stably inherited differentiated cell types and activation of previously silenced genes [107,108]. Ectopic DNA methylation inhibits gene expression [109], whereas drug-inhibition of methylation induces the expression of certain genes [110]. Transfection experiments... 

A retrospective study of 136 BCME workers employed at least 5 years revealed 5 cases of lung cancer, which represented a ninefold increase in lung cancer risks 0.54 cases would have been expected to occur in the plant population. The predominant histologic type of carcinoma was small cell undifferentiated. Exposure ranged from 7.5 to 14 years, and the mean induction period was 15 years. In addition, abnormal sputum cytology was observed in 34% of 115 current workers with exposure to BCME for 5 or more years, as contrasted with 11 % in a control group. 

Patients with other types of unresectable cancer also may benefit from chemotherapy, as evidenced by prolongation of life, shrinkage of tumor, and improvement in symptoms. Notable among these are ovarian epithelial and breast carcinomas, oat cell (small cell undifferentiated) carcinoma of the lung, and acute myelocytic leukemia. Cancers that are for the most part resistant to today s agents include melanoma, colorectal and renal carcinomas, and non-oat cell cancers of the lung. 

Undifferentiated schizophrenia Post-schizophrenic depression Undiffetentiated type... 

Stem cells are undifferentiated cells that have the ability to self-renew and differentiate into other cell types. Stem cells represent a promising model for cell-based therapy [8]. ESCs are self-renewing pluripotent cells derived from the inner cell mass (ICM) of the blastocyst. 

UNDIFFERENTIATED-FORM A type of organism that is not specialized also groups whose structure shows little dissimilarity of cellular structure. 

Chondrites. Over 909, of the meteorites lhat are observed lo fall out of the sky are classified as chondrites, samples lhat are distinguished from terrestrial rocks in many ways. One of the most fundamental is age. Like most meteorites, chondrites have formation ages close to 4.55 Gyr. Chondrites also have basically undifferentiated elemental compositions lor most nonvolatile elements and match solar abundances except for moderately volatile elements. The imtsl cunipositionally primitive chondrites are members for the type I carbonaceous f Cl I class. 

The most convincing evidence for the importance of cytoplasm on nuclear development comes from studies on teratoma, a unique type of tumor found in many kinds of mammals. It is composed both of neoplastic cells, like other tumors, and of many kinds of differentiated cells. A typical teratoma may include nerve, muscle, blood, and skin cells, and other differentiated cells all mixed together with undifferentiated neoplastic stem cells. Only the stem cells are neoplastic, producing more stem cells or more differentiated cells, usually both. In many ways the stem cells behave like... 

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