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Pluripotent cells

Pluripotent cells continue to develop, differentiate, and specialize into different cells. They become the specialized stem cells, such as blood, skin, and nerve stem cells. These differentiated stem cells are multipotent that is, they have the potential to produce specialized cells. For example, blood stem cells in bone marrow produce red blood cells, white blood cells, and platelets, but not other types of cells. [Pg.127]

There are two general avenues for stem cell research pluripotent and multipotent stem cells. Pluripotent stem cells are obtained by two methods. One method is to harvest the clusters of cells from the blastocysts of human embryos. Another method is the isolation of pluripotent cells from fetuses in terminated pregnancies. Multipotent stem cells are derived from umbihcal cords or adult... [Pg.127]

Hockemeyer D, Wang H, Kiani S et al (2011) Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol 29 731-734... [Pg.305]

PLURIPOTENT CELLS IN ADULT FOREBRAIN MAY BE INVOLVED IN NEURONAL REGENERATION... [Pg.15]

Stem cells are undifferentiated cells that have the ability to self-renew and differentiate into other cell types. Stem cells represent a promising model for cell-based therapy [8]. ESCs are self-renewing pluripotent cells derived from the inner cell mass (ICM) of the blastocyst. [Pg.33]

The recognition that cells such as neurons and muscle or cardiac cells, which were previously considered incapable of proliferating in old age, retain the potential for plasticity and regeneration has opened the way to the study of intrinsic and extrinsic factors that may facilitate tissue repair in neurodegenerative diseases of old age. Likewise, the identification of pluripotent cells, such as stem cells, that are potentially capable of acquiring the structure and function of a variety of specialized cells promises to let us effectively replace lost tissues and functions. [Pg.13]

Evans, M.J. and Kaufman, M.H. (1981) Establishment in culture of pluripotent cells from mouse embryos. Nature 292, 154-156. [Pg.74]

Martin, G.1L (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarci-noma stem cells. Proc. Natl. Acad. Sci. USA 78, 7634-7636. [Pg.74]

Dore-Duffy P (2008) Pericytes pluripotent cells of the blood brain barrier. Curr Pharm Des 14 1581-1593... [Pg.158]

Differentiation is the developmental process by which early pluripotent cells acquire the features of late-stage, mature cells such as neurons, hepatocytes, or heart muscle cells. Currently, few examples of devised, highly selective, and efficient conditions for stem cell differentiation into specific homogeneous cell types have been reported because of a lack of understanding of stem cell signaling at the molecular level. Small-molecule phenotypic screens provide another means to generate desired cell types in a controlled manner. Several small molecules have been identified by this method that modulate specific differentiation pathways of embryonic or adult stem cells. [Pg.1725]

Human podocytes cell lines have been developed by transfection of primary cells with SV40TAg or SV40tsA58 alone or in combination with hTERT [140-142], It has been shown that under non-permissive culture they reexpress podocyte markers such as podocin, nephrin, synaptopodin, and P-cadherin [142], The use of kidney progenitor cells and human induced pluripotent cells (iPSC) to produce podocyte-like cells has also been demonstrated and is discussed in more detail in Chap. 15. [Pg.92]

Papp B, Plath K (2013) Epigenetics of reprogramming to induced pluripotency. Cell 152(6) 1324-1343... [Pg.348]

Anokye-Danso F et al (2011) Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 8(4) 376-388... [Pg.349]

Murine embryonic stem (mES) cells are pluripotent cell lines established directly from the early embryo [31, 32]. Since the early 1980s, numerous mES cell lines from several strains have been isolated and maintained in vitro according to... [Pg.408]

DNA adduct formation (dG-C8, dA-C8, dG-N2) in pluripotent cells of taiget oigtins... [Pg.372]

Stem cell. Pluripotent cells, representing 0.01% of bone marrow cells, having the capacity for self-renewal and committed to differentiate along particular lineages, e.g. erythroid, megakaryo-... [Pg.251]


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See also in sourсe #XX -- [ Pg.33 ]

See also in sourсe #XX -- [ Pg.1833 , Pg.1886 ]

See also in sourсe #XX -- [ Pg.1749 ]

See also in sourсe #XX -- [ Pg.366 ]




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Pluripotency

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