Primary thrombocytopenic purpura

Severe infectious disease, primary thrombocytopenic purpura. 

Primary immunodeficiency states, including both antibody deficiencies and combined deficiencies / Idiopathic thrombocytopenic purpura... 

Intravenous Immune Globulin (IGIV) IGIV is a product derived from blood plasma from a donor pool similar to the immune globulin (IG) pool, but prepared so it is suitable for intravenous use. IGIV does not transmit infectious diseases. It is primarily used for replacement therapy in primary antibody-deficiency disorders, for the treatment of Kawasaki disease, immune thrombocytopenic purpura, hypogammaglobulinemia in chronic lymphocytic leukemia, and in some cases of HIV infection. 

Immune globulin, given intramuscularly or intravenously, is recommended in the treatment of primary humoral immunodeficiency, congenital agammaglobulinemias, common variable immunodeficiency, severe combined immunodeficiency, idiopathic thrombocytopenic purpura, and autoimmune hemolytic anemia. There are six licensed preparations of immune globulin. 

Treatment of primary immunodeficiency states in which severe impairment of antibody forming capacity idiopathic thrombocytopenic purpura (IPT) bone marrow transplantation pediatric HIV infection... 

Some reports suggest that anaphylaxis due to intravenous immunoglobulin infusion occurs most often in patients with primary hypogammaglobulinemia (115,116). However, anaphylactic reactions have been seen in two atopic patients with idiopathic thrombocytopenic purpura, and the authors warned that children with atopic disease should not receive intravenous immunoglobulin (117). 

Idiopathic. A term that describes a primary symptom or disease in which no underlying cause or associated disorder could be found. In most cases, autoimmune processes are involved in the pathogenesis (e.g. idiopathic thrombocytopenic purpura, idiopathic Addison disease). 

Thrombocytopenia. Abnormal decrease in the number of thrombocytes below normal values. Frequently detected in patients with autoimmune diseases (e.g. systemic lupus erythematosus, -Sjogren syndrome, mixed connective tissue disease, antiphospholipid syndrome). Primary forms may be drug induced ( - heparin-induced thrombocytopenia) or mediated by antiplatelet antibodies ( - idiopathic thrombocytopenic purpura). 

Two adults with pre-existing primary antibody deficiencies developed recurrent infections immediately after receiving rituximab for refractory idiopathic thrombocytopenic purpura [161 ]. The temporal relation between rituximab administration and the onset of infection suggested that rituximab accelerated immune deficiency in these patients. 

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