Thrombocytopenic purpura-hemolytic

Idiopathic or secondary thrombocytopenic purpura, hemolytic anemia, red blood cell anemia, congenital hypoplastic anemia... 

Medina, P.J., Sipols, J.M., and George, J.N., Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome, Curr. Opin. Hematol., 8, 286, 2001. 

Gl Melena anorexia nausea vomiting constipation taste alteration diarrhea. Hematologic Bone marrow depression thrombocytopenia thrombocytopenic purpura hemolytic anemia leukopenia pancytopenia agranulocytosis. 

Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) TTP/HUS which has resulted in death, has occurred in immunocompromised patients receiving acyclovir therapy. 

Among the adverse events that were reported at a rate of 3% or more and less than 20%, the following were more prominent in patients maintained on sirolimus 5 mg/day vs 2 mg/day Epistaxis, lymphocele, insomnia, thrombotic thrombocytopenic purpura (hemolytic-uremic syndrome), skin ulcer, increased LDH, hypotension, facial edema. 

Bell, W. R., Braine, H. G., Ness, P. M., and Kidder, T. S., Improved survival in toom-botic thrombocytopenic purpura hemolytic-uremic-syndrome-cUnical experience in 108 patients. 

Warning Acyclovir sodium is intended only for intravenous infusion, which should be given over a period of 1 hour to reduce the risk of renal tubular damage Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), which has resulted in death, has occurred in immunocompromised patients receiving acyclovir therapy. 

George JN. How I treat patients with thrombotic thrombocytopenic purpura- hemolytic uremic syndrome. Blood 2000 96 1223-1229. 

Rarely reported hematological reactions to various neuroleptic drugs include agranulocytosis, thrombocytopenic purpura, hemolytic anemia, leukopenia, and eosinophilia. These are thought to represent allergic or hypersensitivity reactions, although this has been questioned in one detailed case report of chlorpromazine-induced agranulocytosis (514). 

The differential diagnosis includes a number of viral and bacterial diseases, including influenza, meningo-coccemia. Rocky Mountain spotted fever, malaria, and others, as well as noninfectious causes such as idiopathic and thrombotic thrombocytopenic purpuras, hemolytic uremic syndrome, and DlC (disseminated intravascular coagulation). 

Like acyclovir, valacyclovir is a well-tolerated drug. The most common adverse effects of valacyclovir are headache and nausea. Other adverse events associated with valacyclovir administration include vonuting, weakness, cUzziness, and abdoiifinal pain. Thrombotic thrombocytopenic purpura/ hemolytic ureiiuc syndrome has also been reported in a few patients after high doses of valacyclovir, as has confusion, hallucinations, and nephrotoxicity (Curran and Noble, 2001 Perry and Faulds, 1996). 

Leach JW, Pham T, Diamandidis D, George JN. Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) following treatment with deoxycoformycin in a patient with cutaneous T cell lymphoma (Sezary syndrome) A case report. Am J Hematol 1999 61(4) 268-70. 

Dioti J.S, Danielson CF, Blue-Flindy DE, McCarthy LJ Drug-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. A concise review.Ther. Apher.2004 8 102-111... 

DIott JS, Danielson CE, Blue-FI nidy DE, and McCarthy LJ. 2004. Drug-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome a concise review. TherApherDial8 102-111. 

Acute intrinsic renal failure Vascular Vasculitis Polyarteritis nodosa Thrombotic thrombocytopenic purpura Hemolytic uremic syndrome Emboli Cholesterol Thrombotic... 

Kojouri K, Vesely SK, George JN (2001) Quinine-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome firequency, clinical features, and long-term outcrunes. Ann Intern Med 135 1047-1051... 

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