Corticosteroids idiopathic thrombocytopenic purpura

Idiopathic thrombocytopenic purpura is an immune-mediated disease in which immunoglobulin, either as antibody directed against platelet antigens or nonspecifically bound to platelets, is present in increased quantities on platelets. This leads to increased destruction of platelets and, in many instances, megakaryocytes. Standard treatment consists of corticosteroids and splenectomy (72). When these measures fail, treatment may include androgenic steroids, administration of intravenous 7-globulin, or injection of vinca alkaloids. 

Idiopathic thrombocytopenic purpura (ITP) Immune globulin (IV)2 Consult the manufacturer s dosing recommendations for the specific product being used. Response in children with ITP is greater than in adults. Corticosteroids are the treatment of choice in adults, except for severe pregnancy-associated ITP. 

Andres E, Zimmer J, Noel E, Kaltenbach G, Koumarianou A, Maloisel F. Idiopathic thrombocytopenic purpura a retrospective analysis in 139 patients of the influence of age on the response to corticosteroids, splenectomy and danazol. Drugs Aging 2003 20(ll) 841-6. 

Kappers-Klunne MC, van t Veer MB. Cyclosporin A for the treatment of patients with chronic idiopathic thrombocytopenic purpura refractory to corticosteroids or splenectomy. Br J Haematol 2001 114(l) 121-5. 

Papadopoulos A, Ntaios G, Kaiafa G, Girtovitis F, Charisopoulos G, Chryssogonidis I. Fatal pulmonary and cerebral aspergillosis after a short course of corticosteroids for idiopathic thrombocytopenic purpura. Ann Hematol 2008 87(8) 685-6. 

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