Tricyclic anti-depressants

The classic and standard tricyclic anti-depressive, imipramine, has an... 

Predict the order of elution of the the following tricyclic anti-depressants from a CE system with the following running buffer 0.5 mM buffer pH 9.55/methanol (84.6 15.4). 

Tricyclic anti-depressive drugs Cyclodextrin-modified SPCE 0.196 pM 2.75 pM Serum (86-98) 0.04-0.5 pM Differential pulse voltammetry Ferancova et al. [133]... 

Tricyclic anti-depressive drugs 520 Trimeprazine base e29 Trimethylamine, ornithine, amines, histamine, hypoxanthine 257 Trinitrocompounds 877 TSM 815 Tumour cell 102 Turnover number 919 Tween 20 808, 814 Two-photon effect 100... 

As with some other quinolones, moxifloxadn also prolongs the QTC interval [265], although the prolongation time of 4—6 ms (i.e., 1.4—1.6% of the starting interval) is relatively minimal. For safety reasons, the treatment of patients with QT interval prolongation and certain cardiac diseases is therefore contraindicated. Other medicaments with a potential for prolonging the QT interval may not be administered simultaneously with moxifloxacin. These indude anti-arrhythmic drugs of class IA (e.g., quinidine, hydroquinidine, disopyramide) and III (e.g., amiodarone, sotalol, dofetilide, ibutilide), intravenous erythromydn, tricyclic anti-depressives, and cisapride etc. 

Amitriptyline hydrochloride a tricyclic anti-depressant drug which inhibits serotonin and noradrenaline re-uptake. 

Peterman, S.M. et al., Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies Examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements, J. Am. Soc. Mass Spectrom., 17(3), 363, 2006. 

Alprazolam (National Institute of Mental Health study) Tricyclic anti-depressants (imipramine)... 

Neither 5-hydroxytryptamine nor related agonists have found a clinical use. The tricyclic anti-depressants (Section 12.9) seem to act by inhibiting uptake of both 5-hydroxytryptamine and the catecholamines. Two antagonists of 5-... 

The valuable properties of the tricyclic anti-depressant drugs seem to stem from an ability to increase the availability of norepinephrine and 5-hydroxy-tryptamine. Closer study has revealed both a pro- and anti-5-hydroxytryp-tamine effect, as well as a pro- and an anti-norepinephrine effect, but at different times in the treatment or at different loci in the brain (Koe, 1983 Pillion and Pillion, 1981). Many scientists are working in this field and we must await the results of their efforts. 

The tricyclic anti-depressants usually have a p of 9.5 to 10 and a partition coefficient of 4 in the system octanol/water. Improvement in their therapeutic performance has followed two directions, both leading to products without effect on the heart. First came the tetracyclic anti-depressants such as mapro-tiline 12.116) and mianserin 12.117). Then there are anti-depressant drugs with much simpler nuclei such as nomifensine 12.118). These newer products... 

Patients who do not respond to the tricyclic anti-depressants have two alternative therapies available, both of which increase the availability of neurotransmitter amines in the brain. The monoamine oxidase inhibitors (Section 9.4, p. 359) are highly effective but impose dietary restraints and have often caused dangerous surges in blood-pressure. Electroconvulsive therapy, which may sound brutal, but is actually painless to the patient, can achieve lasting improvement (Green, Heale and Grahame-Smith, 1977). 

Since the primary purpose of this review is to study the opiates and their immediate derivatives, it is not proposed to examine in detail the interactions of the weak, peripherally-acting analgesics with neuronal transmitters readers interested in this group of drugs per se may consult reviews by Randall [4] and De Stevens [5]. However, this is not to totally dismiss as unimportant the role of central neuronal transmitters in the formulation and perception of some forms of chronic inflammatory or somatic pain a number of recent reports have demonstrated the value of certain tricyclic anti-depressant agents in alleviating this type of pain in man [6,7]. 

Figure 4.6 On the bandwith of retention and separation (actors by the separation of metabolites of tricyclic anti-depressants in acetonitrile/acidic phosphate buffer. Reproduced from Kromidas [6] with permission of John Wiley Sons.

An RP mechanism can be enforced by the pH value. If a uniform state of ionization of the analytes that are to be separated is generated by a given pH value (here, suppression of ionization), then their individual polar character recedes into the background, and the separation runs purely according to their different organic character. As mentioned above, apolar interactions result in a narrow range of selectivities, and the a values are small and similar. Figure 7 shows the retention and separation factors for the separation of tricyclic anti-depressants in an acidic phosphate buffer on several different phases. 

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