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Terbutaline

10 ml of pure thiophene-2-aldehyde and 0.25 g of anhydrous zinc chloride are added to 0.5 g of dried 4 -demethylepipodophyllotoxin-/3-D-giucoside and the mixture is shaken on a machine at 20 C in the absence of moisture, whereupon a clear solution is gradually obtained. The course of condensation is checked by thin layer chromatography. After a reaction period of 3 to 4 hours the solution is diluted with chloroform and shaken out with water. The chloroform phase is washed twice more with a small amount of water and then dried over sodium sulfate and concentrated by evaporation. Excess thiophene-2-aldehyde is removed by dissolving the resulting residue in a small amount of acetone and reprecipitation is effected by adding pentane. [Pg.1445]

Reprecipitation from acetone/pentane is repeatedly effected until the condensation product suits in flaky form. Further purification is effected in that the crude product is chromatographed on silica gel. The fractions which are uniform in accordance with thin layer chromatography are combined and yield crystals from absolute alcohol. Pure 4 -demethylepipo-dophyllotoxin-/3-D-thenylidene glucoside has a melting point of 242°C to 246°C (last residue up to 255°C). [Pg.1445]

Chemical Name 1 -(3, 5 -Dihydroxyphenyi)-2-(t-butylamino)-ethanol Common Name — [Pg.1445]

Trade Name Manufacturer Country Year Introduced [Pg.1445]

To a solution of 32 g of benzyl-t-butylamine in 300 ml of absolute ethanol at reflux temperature was added 32 g of 3,5-dibenzyloxy-CObromoacetophenone in 10 ml of dry benzene. The mixture was refluxed for 20 hours and then evaporated. When absolute ether was added to the residue, benzyl-t-butylamine hydrobromide was precipitated. The precipitated compound was filtered off and to the filtrate was added an excess of 2 N sulfuric acid. This caused precipitation of the hydrogen sulfate of 3,5-dibenzyloxy-CO-(benzyl-t-butylamino)-acetophenone which was recrystallized from acetone/ether. If the product is crystallized from different organic solvents, the melting point will vary with the type and amount of solvent of crystallization, but the product can be used directly for hydrogenation. [Pg.1446]

The hydrogen sulfate was dissolved in water and the pH of the solution was adjusted to 5.6 (pH-meter) with 0.1 N sodium hydroxide solution. The water solution was evaporated to dryness and the residue dried with absolute ethanol/benzene and once more evaporated to dryness. The remaining crystal mixture was extracted in a Soxhiet extraction apparatus with absolute methanol. From the methanol phase the sulfate of 1-(3, 5 -dihydroxyphenyl)-2-(t-butylaminoj-ethanol crystallized. Melting point 246 to 248°C. [Pg.1446]


Clenbuterol [37148-27-9] C 2H gCl2N20, (6) (54), a nonphenolic analogue of terbutaline, is not susceptible to COMT or to conjugation. It has a long plasma half-life (20 h), but does not seem to differ ia pharmacological half-life from albuterol (55). [Pg.440]

Benzpyrinium bromide Phentermine HCI N -Benzyl-N-tert-butylamine Carbuterol Terbutaline... [Pg.1616]

Feximac cream - Bufexamac F.H. -Tegafur Fiblaferon - Interferon Fibocil - Aprindine HCI Fiboran - Aprindine HCI Fibutox -Oxyphenbutazone Ficoid - Fluocortolone Fidesbiotic -Ampicillln Fidesporin - Cefazolin sodium Fidocin Demedocydine HCI Filacul - Tegafur Filair -Terbutaline... [Pg.1700]

Most of the chiral membrane-assisted applications can be considered as a modality of liquid-liquid extraction, and will be discussed in the next section. However, it is worth mentioning here a device developed by Keurentjes et al., in which two miscible chiral liquids with opposing enantiomers of the chiral selector flow counter-currently through a column, separated by a nonmiscible liquid membrane [179]. In this case the selector molecules are located out of the liquid membrane and both enantiomers are needed. The system allows recovery of the two enantiomers of the racemic mixture to be separated. Thus, using dihexyltartrate and poly(lactic acid), the authors described the resolution of different drugs, such as norephedrine, salbu-tamol, terbutaline, ibuprofen or propranolol. [Pg.15]

Recently, the separation of some milligram quantities of terbutaline by classical gel electrophoresis has been reported [194]. A sulfated cyclodextrin impregnated on the agarose gel was used as a chiral selector and the complete resolution was achieved in 5 h. Analogously, small amounts of enantiomers can be isolated using thin-layer... [Pg.16]

Fig. 11-1. Effect of the addition of methanol on the enantiomeric separation of terbutaline using 2 % sulfated cyclodextrin in 25 mM phosphate buffer (pH 3). Fig. 11-1. Effect of the addition of methanol on the enantiomeric separation of terbutaline using 2 % sulfated cyclodextrin in 25 mM phosphate buffer (pH 3).
Tocolytics are drugs such as the selective (32-adrenoceptor agonists, e.g. salbutamol or terbutaline, which inhibit both the spontaneous and oxytocin-induced contractions of the pregnant uterus by relaxing... [Pg.1203]

Examples of sympathomimetic bronchodilators include albuterol (Ventolin), epinephrine (Adrenalin), salme-terol (Serevent), and terbutaline (Brethine). Many of the sympathomimetics used as bronchodilators have die subclassification of beta-2 ((32) receptor agonists (eg, albuterol, salmeterol, and terbutaline). Additional information concerning the various sympathomimetic dragp is given in the Summary Drug Table Bronchodilators. [Pg.334]

Large doses of IValbuterol or IV terbutaline may aggravate diabetes mellitua Diabetic patients may require an increase in insulin dosage or oral hypoglycemic drug. [Pg.345]

Adverse reactions observed with the administration of terbutaline include nervousness, restlessness, tremor, headache, anxiety, hypertension, hypokalemia (low serum potassium), arrhythmias, and palpitations. A serious, but rare, adverse reaction is pulmonary edema... [Pg.564]

Before starting an IV infusion containing ritodrine or terbutaline, the nurse obtains the patient s vital signs. The nurse auscultates lung sounds to provide a baseline assessment. The nurse places the patient on a monitoring device to determine uterine contractions and the FHR before and during administration. [Pg.564]

If oral terbutaline is prescribed for preterm labor, die patient is instructed on use of die drug and adverse reactions to report (excessive tremor, nervousness, drowsiness, headache, nausea, dizziness). If contractions resume during oral dierapy, die patient is instructed to notify die primary healdi care provider if four to six contractions per hour occur. [Pg.565]

Terbutaline 2.5 mg is prescribed. The drug is available in 5-mg tablets. The nurse administers. ... [Pg.566]

Bricantyl (Astra)-comb. with terbutaline sulfate Dolestan forte (Whitehall-Much)-comb. [Pg.983]

Terbutalin (Mundipharma Stada Aluid Pharma ratiopharm)... [Pg.1992]


See other pages where Terbutaline is mentioned: [Pg.967]    [Pg.439]    [Pg.439]    [Pg.445]    [Pg.446]    [Pg.142]    [Pg.258]    [Pg.263]    [Pg.1445]    [Pg.1445]    [Pg.1675]    [Pg.1679]    [Pg.1680]    [Pg.1680]    [Pg.1680]    [Pg.1680]    [Pg.1747]    [Pg.142]    [Pg.148]    [Pg.83]    [Pg.365]    [Pg.336]    [Pg.337]    [Pg.349]    [Pg.563]    [Pg.564]    [Pg.564]    [Pg.564]    [Pg.564]    [Pg.564]    [Pg.565]    [Pg.176]    [Pg.1992]    [Pg.1992]   
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Atenolol Terbutaline

Beta-adrenergics terbutaline

Brethaire - Terbutaline

Brethine - Terbutaline

Bricanyl - Terbutaline

Bronchodilator terbutaline sulfate

Enantiomer terbutaline

Filair - Terbutaline

Furosemide Terbutaline

Halothane Terbutaline

Hormonal) Terbutaline

Labor, premature, terbutaline

Metoprolol Terbutaline

NSAIDs) Terbutaline

Oxprenolol Terbutaline

Temperature Terbutaline

Terbutalin

Terbutalin

Terbutaline 3-agonist

Terbutaline Aminophylline

Terbutaline Propranolol

Terbutaline Theophylline

Terbutaline Toloxatone

Terbutaline adverse effects

Terbutaline applications

Terbutaline arrhythmia with

Terbutaline determination

Terbutaline formulation

Terbutaline in asthma

Terbutaline pharmacokinetics

Terbutaline prodrug

Terbutaline sulfate

Terbutaline sulphate

Terbutaline, asthma

Terbutaline, clinical studies

Terbutaline, uterine selectivity

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