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Terbutaline prodrug

T Anders, LA Svensson. Bambuterol, a carbamate ester prodrug of terbutaline, as inhibitor of cholinesterases in human blood. Drug Metabol Dispos 16(5) 759-763,... [Pg.230]

A. Tunek, E. Levin, L. A. Svensson, Hydrolysis of 3H-Bambuterol, a Carbamate Prodrug of Terbutaline, in Blood from Humans and Laboratory Animals in vitro , Biochem. Pharmacol. 1988, 37, 3867-3876. [Pg.545]

Prodrugs have been designed to improve corneal absorption. This approach has been applied with epinephrine (226-230), terbutaline (231), various prostaglandins (232), phenylephrine (233-235), and pilocarpine (236-241). For some pilocarpine derivatives the double prodrug approach has been used to overcome eye irritation and improve on poor water solubility (240,241) (Section 5.4). [Pg.519]

Bambuterol is an inactive prodrug which is slowly converted enzymatically in the body to its active form, terbutaline. The carbamate groups that are split off can selectively inhibit the plasma cholinesterase that is necessary for the metabolism of suxamethonium and mivacurium. As a result, the metabolism of these neuromuscular blockers is reduced and their effects are thereby prolonged. The effect appears to be related to the dose of the... [Pg.118]

Figure 8.42 Protection of phenolic hydroxyl groups in terbutaline by use of bambuterol prodrug. Figure 8.42 Protection of phenolic hydroxyl groups in terbutaline by use of bambuterol prodrug.
See other pages where Terbutaline prodrug is mentioned: [Pg.176]    [Pg.522]    [Pg.204]    [Pg.497]    [Pg.545]    [Pg.176]    [Pg.1247]    [Pg.413]    [Pg.270]    [Pg.14]    [Pg.142]    [Pg.143]    [Pg.143]    [Pg.143]    [Pg.71]    [Pg.562]    [Pg.563]    [Pg.152]    [Pg.99]    [Pg.1937]   
See also in sourсe #XX -- [ Pg.2 , Pg.504 ]

See also in sourсe #XX -- [ Pg.174 , Pg.175 , Pg.201 ]



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