Terbutaline determination

Before starting an IV infusion containing ritodrine or terbutaline, the nurse obtains the patient s vital signs. The nurse auscultates lung sounds to provide a baseline assessment. The nurse places the patient on a monitoring device to determine uterine contractions and the FHR before and during administration. 

Carbamazepine, antipyrine, terbutaline, and hydrochlorothiazide were treated as neutral molecules. Their effective permeabilities were corrected for the unstirred water layer using estimated unstirred water layer permeabilities, determined by the other molecules of similar lipophilicities and size. 

Kim, K.H., Kim, H.J., Kim, J.-H., Shin, S.D. (2001). Determination of terbutaline enantiomers in human urine by coupled achiral-chiral performance liquid chromatography with fluorescence detection. Chromatogr. B 751, 69-77. 

Walhagen, A., Edholm, L.E., Kennedy, B.M., Xiao, L.C. (1989a). Determination of terbutaline enantiomers in biological samples using liquid chromatography with coupled columns. Chirality 1, 20-26. 

Because total cholesterol is composed of cholesterol derived from LDL, VLDL, and HDL, determination of HDL is useful when total plasma cholesterol is elevated. HDL may be elevated by moderate alcohol ingestion (fewer than two drinks per day), physical exercise, smoking cessation, weight loss, oral contraceptives, phenytoin, and terbutaline. HDL may be lowered by smoking, obesity, a sedentary lifestyle, and drugs such as /1-blockers. 

Online-dual-column extraction coupled to enantioselective LC-MS was used for the determination of terbutaline enantiomers in human plasma on a commercially available TE CSP [120]. 

Xia, Y.-Q., Liu, D.Q., and Bakhtiar, R., Use of online-dual-column extraction in conjunction with chiral liquid chromatography tandem mass spectrometry for determination of terbutaline enantiomers in human plasma. Chirality, 14, 742, 2002. 

Several groups have investigated the effect of surfactants on emitted droplet size. In the early work performed by Polli et al., the surfactant sorbitan trioleate decreased the MM AD of the CFC dexamethasone suspension when added to the formulation (52). A suspension of terbutaline in a CFC system containing sorbitan trioleate surfactant was shown to have little change in emitted particle size when either 2.8 or 14mg/mL of surfactant was added (53). Interestingly, the surfactant had a significant effect on the obscuration (droplet concentration) of the laser diffraction instrument used to determine particle size. Surfactants may lead to an increase in MMAD due to decreased evaporation rates from aerosol droplets. This may occur because of their tendency to associate at the air liquid interface (54). 

G. A. Jacobson and G. M. Peterson, High-performance liquid chromatographic assay for the simultaneous determination of opratropium bromide, fenoterol, salbutamol and terbutaline in nebulizer solution, J. Pharm. Biomed. Anal., 72 111 (1994). 

Kondo et al. (1992) determined the effects of dobu-tamine and terbutaline on adenylate cyclase activity and cyclic AMP content in the renal pelvis of rabbits. 

Determination of drug enantiomers in biological samples by coupled column liquid chromatography and liquid chromatography-mass spectrometry" (72). The direct separation and determination of the enantiomeric composition of terbutaline in human plasma at the nmol/L level... 

TSP LC-MS in combination with coupled-column chromatography was used to separate and determine drag enantiomers of terbutaline (225 Da) in human plasma [76]. The (-)terbutaline enantiomer is pharmacologically active. The method was developed for single-dose pharmacokinetic studies to determine the plasma... 

Figure 4.13 Coupled-column LC-MS system for the determination of terbutaline enantiomers in plasma (Reprinted with permission from [76], 1988, Elsevier Science).

For drugs that show significant oral bioavailability (e.g., salbutamol [75]), terbutaline sulfate [76], budesonide [77]), different approaches, such as the charcoal-block technique, or the knowledge of differences in the pulmonary and GI absorption lag times can be utilized to determine the pulmonary fate of the inhaled drug. 

MT Ackermans, JL Beckers, FM Everaerts, IGJA Seleen. Comparison of isotacho-phoresis, capillary electrophoresis and high performance liquid chromatography for the determination of salbutamol, terbutaline sulphate and fenoterol hydrobromide in pharmaceutical dosage forms. J Chromatogr 590 341-353, 1992. 

He D, Zhang Z, Zhou H, Huang Y. Micro flow sensor on a chip for the determination of terbutaline in human serum based on chemiluminescence and amolecularly imprinted polymer. Talanta 2006 69 1215-20. 

Sagar, K.A. Kelly, M.T. Smjrth, M.R. Simultaneous determination of salbutamol and terbutaline at overdose levels in human plasma by high performance liquid chromatography with electrochemical detection. Biomed.Chromatogr., 1993, 7, 29—33... 

M. Strandberg and S. Thelander, A Microprocessor-Controlled Flow Injection Analyser for the Determination of Terbutaline Sulphate. Anal. Chim. Acta, 145 (1983) 219. 

Borgstrbm L, Nilsson M. A method for determination of the absolute pulmonary bioavailability of inhaled drugs terbutaline. Pharm Res 1990 7 1068-1070. 

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