Oral hypoglycemics

Oral hypoglycemics Oral contraceptives Theophylline Opiates... 

Hydroxylation, osmium tetroxide, 138 Hypoglycemics, oral, 20 Hypotensive agent, 5... 

Hypoglycemics, oral [P] Dicumarol inhibits hepatic metabolism of tolbutamide and chlorpropamide. 

Hypoglycemics, Oral, Pages 562-563, Henry A. Splller SummaryPlus Full Text + Links PDF (68 K)... 

Table 2. Sulfonylureas Used as Oral Hypoglycemic Agents...

Yet another example of a so-called pharmacophoric group is the biguanide functionality, a grouping associated with oral antidiabetic activity (see the section on sulfonylureas for a fuller discussion of this activity). Condensation of 2-phenethylamine with dicyanamide affords directly the orally active hypoglycemic agent phenformin (88). ... 

Treatment of piperidine with nitrous acid affords the N-nitroso derivative (190) reduction gives the corresponding hydrazine (191). Condensation of this intermediate with the carbamate (192) obtained from p-toluenesulfonamide leads to the oral hypoglycemic agent tolazemide (193). In a similar vein, reaction of the hydrazine obtained by the same sequence from azepine (194) with the carbamate, 188, gives azepinamide (195). ... 

Perhaps surprisingly, the p-methyl benzenesulfonylurea analogue called tosi fen (45), which is structurally rather close to the oral hypoglycemic agents, is an anti anginal agent... 

Meglitinide contains a benzamide group. Meglitinide-related compounds such as nateglinide are non-sulfonylurea oral hypoglycemic drugs used in the treatment of type 2 (non-insulin dependent) diabetes mellitus. 

Sulfonamides may inhibit the (hepatic) metabolism of the oral hypoglycemic drugs tolbutamide (Orinase) and chloq ropamide (Diabinese). This would increase the possibility of a hypoglycemic reaction. 

The effects of oral hypoglycemic drugs, oral anticoagulants, and phenytoin may be increased when administered with chloramphenicol. Fhenobarbital or rifampin may decrease chloramphenicol blood levels. 

Large doses of IValbuterol or IV terbutaline may aggravate diabetes mellitua Diabetic patients may require an increase in insulin dosage or oral hypoglycemic drug. 

Propranolol may alter the effectiveness of insulin or oral hypoglycemic dm. Dosage adjustments may be necessary. 

Report elevated glucose levels to the primary health care provider as soon as possible because an adjustment in the dosage of insulin or oral hypoglycemic drug3 may be necessary. 

---