Terbutaline applications

Most of the chiral membrane-assisted applications can be considered as a modality of liquid-liquid extraction, and will be discussed in the next section. However, it is worth mentioning here a device developed by Keurentjes et al., in which two miscible chiral liquids with opposing enantiomers of the chiral selector flow counter-currently through a column, separated by a nonmiscible liquid membrane [179]. In this case the selector molecules are located out of the liquid membrane and both enantiomers are needed. The system allows recovery of the two enantiomers of the racemic mixture to be separated. Thus, using dihexyltartrate and poly(lactic acid), the authors described the resolution of different drugs, such as norephedrine, salbu-tamol, terbutaline, ibuprofen or propranolol. 

Pj-selective agonists such as prenalterol (Figure 10.5) or dobutamine are used to stimulate heart contractility and heart rate in patients that exhibit too low blood pressure. P2-Selective agents such as terbutaline find application for relaxation and dilatation of the bronchi in the treatment of asthma or chronic obstmctive lung disease, and in the suppression of premature labour. The mechanism of P-receptor-induced relaxation of smooth muscle - cAMP-mediated phosphorylation and inhibition of myosin light chain kinase - has been described before. 

Model applications include terbutaline s effect on lowering plasma potassium levels (9, 35) and stimulation of the factors controlling heat loss by the antipyretic effect of nonsteroidal anti-inflammatory drugs (36). 

Alternately, topical application of nitroglycerin paste and infiltration of terbutaline have been reported successful. 

Stalcup AM, Gahm KH, Gratz SR, Sutton RC (1998) Application of classical gel electrophoresis to the chiral separation of milligram quantities of terbutaline. Anal Chem 70 144-148... 

Henze, M.K., Opfermann, G., Spahn-Langguth, H., and Schanzer, W. (2001) Screening of beta-2 agonists and confirmation of fenoterol, orciprenaUne, reproterol and terbutaline with gas chromatography-mass spectrometry as tetrahydroisoquinohne derivatives. Journal of Chromatography B, Biomedical Sciences and Applications, 751,93-105. 

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