Labor, premature, terbutaline

Tocolysis. The uterine relaxant effect of P2-adrenoceptor agonists, such as terbutaline or fenoterol, can be used to prevent premature labor. Vasodilation Ltillmann, Color Atlas of Pharmacology (... 

In addition to its use as a bronchodilator, terbutaline is used extensively to control premature labor, since contractions of uterine smooth muscle are abolished by adrenomimetics (see Chapter 62). 

Terbutaline (Brethine, Bricanyl) is a relatively specific P2-adrenoceptor agonist (see Chapters 10 and 39). Terbutaline can prevent premature labor, especially in individuals who are more than 20 weeks into gestation and have no indication of ruptured fetal membranes or in whom labor is not far advanced. Its effectiveness in premature labor after 33 weeks of gestation is much less clear. Terbutaline can decrease the frequency, intensity, and duration of uterine contractions through its ability to directly stimulate Pj-adrenoceptors. While it appears to be especially selective for P2-receptor activation, terbutaUne does have some Pi activity as well. 

Terbutaline is frequently used in the management of premature labor, although it has not been marketed for such use. Its effectiveness, side effects, precautions, and contraindications are similar to those of all P2-adrener-gic agonists. Terbutaline can cause tachycardia, hypotension, hyperglycemia, and hypokalemia. It can be given orally in addition to subcutaneous or intravenous administration. 

Terbutaline [ter BYOO te leen] is a p2 agonist with more selective properties than metaproterenol and a longer duration of action. Terbutaline can be administered either orally or subcutaneously. It is used as a bronchodilator and to reduce uterine contractions in premature labor. 

Terbutaline Ritodrine Albuterol P2 Treatment of bronchospasm and premature labor... 

Acute paraparesis occurred after an injection of terbutaline sulfate for premature labor in a 26-year-old woman (1). 

Terbutaline is used as a bronchodilator and for the prevention of premature labor. Unlabeled use includes treatment of hyperkalemia. 

The uterus contains both alpha- and beta2-adrenergic-receptor sites. Stimulation of the alpha-receptor site causes contraction stimulation of the beta2-receptor site causes relaxation. Therefore, beta2-receptor agonists such as rito-drine hydrochloride (Yutopar) and terbutaline sulfate (Brethine) are used to suppress premature labor. 

Terbutaline, a bronchodilator (5 mg given p.o. at 6 hour intervals 3 times during waking hours), is indicated for rehef of bronchospasm in patients with reversible obstructive airway disease (see Figure 94) and terbutaline, a tocolytic agent (10 mcg/minutes fV), is also used in managing premature labor. 

The responses of uterine muscle to Epi vary with phase of the sexual cycle, state of gestation, and dose. During the last month of pregnancy and at parturition, Epi inhibits uterine tone and contractions. fi -Selective agonists (e.g., ritodrine or terbutaline) can delay premature labor, although... 

Salmeterol, albuterol, and terbutaline used in asthma ° Ritodrine, used in premature labor... 

Genitourinary tract Beta, agonists tritodrine, terbutaline) are used to suppress premature labor, but the cardiac stimulant effect may be hazardous to both mother and fetus. Nonsteroidal anti-inflammatory drugs, calcium channel blockers, and magnesium are also used for this indication. 

Bey, M., Blanchard, A, C., Darnell, J., and Stephens, K. (1992), Myocardial necrosis in a newborn after long-term maternal. subcutaneous terbutaline for suppression of premature labor. Am. J. Ohslct. Gynecol. 167, 292,... 

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