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Teratogenicity studies

Reproductive Toxicity. No data are available that impHcate either hexavalent or trivalent chromium compounds as reproductive toxins, unless exposure is by way of injection. The observed teratogenic effects of sodium dichromate(VI), chromic acid, and chromium (HI) chloride, adininistered by injection, as measured by dose-response relationships are close to the amount that would be lethal to the embryo, a common trait of many compounds (111). Reported teratogenic studies on hamsters (117,118), the mouse (119—121), and rabbits (122) have shown increased incidence of cleft palate, no effect, and testicular degeneration, respectively. Although the exposures for these experiments were provided by injections, in the final study (122) oral, inhalation, and dermal routes were also tried, and no testicular degeneration was found by these paths. [Pg.141]

Mn Inhalation Teratogenicity Study in the Mouse with Cyclohexanone, a study performed by Bio /dynamics, Inc., East Millstone, N.J., for The Industrial Health Foundation, Aug. 1984. [Pg.428]

ORTEPA (1994) DIbutyltIn dichlorlde oral (gavage) teratogenicity study In the rat. Hazelton-Deutschland GmbH, November, for the Organotin Environmental Programme Association (HD Project No. 380-211). [Pg.49]

Schering AG (1991) ZK 30.434. Embryotoxicity including teratogenicity study in the rat after daily intragastric administration from day 6 to day 15 of gestation. Berlin, Schering AG, 25 July (Research Report No. IC18/90). [Pg.50]

Dan B, Medda JN. 1990. Teratogenic studies of methyl parathion on chick embryos. In , ed. Impacts of environment on animals and aquaculture. Kalyani, West Bengal University of Kalyani, 241-245. [Pg.200]

FMC. 1972. Teratogenic study with thiodan technical in albino rats. Conducted for Food Machinery and Chemical Corporation, Niagara Chemical Division. Industrial Bio-Test Laboratories, Inc., Northbrook, IL. [Pg.292]

Robinson EC, Hammond BG, Johannsen FR, et al. 1986. Teratogenicity studies of alkylaryl phosphate ester plasticizers in rats. Fundam Appl Toxicol 7 138-143. [Pg.349]

Twenty-three teratogenicity studies in which lead compounds (acetate or nitrate) were administered in the drinking water or feed or by gavage to rats and mice have shown no evidence that lead causes... [Pg.202]

Hodge, M.C.E., M.Kilmartin, R.A.Riley, T.M.Weight, and J.Wilson. 1979. Arcton 134a teratogenicity study in the rat. ICI Report no. CTL/P/417. Central Toxicology Laboratory, Alderly Park, Macclesfield, Cheshire, U.K. [Pg.172]

Lu, M., and R.Staples. 1981. 1,1,1,2-Tetrafluoroethane (FC-134a) embryo-fetal toxicity and teratogenicity study by inhalation in the rat. Report No. 317-81. Haskell Laboratory, Wilmington, DE. (Cited in NRC 1996). [Pg.172]

Wickramaratne, G.A. de S. (1988). The post-natal fate of supernumerary ribs in rat teratogenicity studies. J. Appl. Toxicol. 8 91-94. [Pg.296]

Segment 11 teratogenicity study. This concentrates on the most sensitive part of gestation, from the time of implantation imtil major organogenesis is complete. This is the period during which a test substance is most likely to cause malformation of the embryo. Exposure of the mother to the test substance is usually confined to this period. Conventionally, the study is conducted in rats and rabbits. Rabbits are intolerant to antibiotics and the mouse is an acceptable alternative in most cases. [Pg.128]

Segment 111 peri- and post-natal study. This concentrates on the late part of gestation, not covered by the teratogenicity study, on parturition and on the period of lactation. The study can be particularly useful in detecting subtle effects on the brain, which continues physical and functional development during the foetal and post-natal period, after dosing has ceased in the teratogenicity study. The test animal is usually the rat. [Pg.128]

Embryo-foetal development (rat and rabbit). This is a standard Segment II, teratogenicity study. [Pg.129]

Mathur A, Bhatnagar P A teratogenic study of carbaryl in Swiss albino mice. Eood Chem ToxiVo/29 629-632, 1991... [Pg.118]

Culik R, et al P-Chloroprene (2-chlorobuta-diene-1,3) embryotoxic and teratogenic studies in rats (abstr no 194). Toxicol Appl Pharmacol hi 12, 1976... [Pg.167]

Noda T Teratogenicity studies of two kinds of di- -butyl substituted compounds in rats. Jpn J Pharmacol (Swpp 1) 298 (Abstract), 1996... [Pg.217]

Hansen E, Meyer O Embryotoxicity and teratogenicity study in rats dosed epicutaneously with dimethylformamide (DME). J Appl Toxicol 10 333-338, 1990... [Pg.267]

Khera KS Ethylene thiourea Teratogenicity study in rats and rahhits. Teratology 7 243, 1973... [Pg.332]

Khera K, Whalen C, Trivett G Teratogenicity studies on linuron, malathion, and methoxychlor in rats. Toxicol Appl Pharmacol 45 435M44, 1978... [Pg.431]

Kaneda M, Hojo H, Teramoto S, et ah Oral teratogenicity studies of methyl bromide in rats and rabbits. Food Chem Toxicol 36(5) 421-127, 1998... [Pg.459]

Becci PJ, Knickerbocker MJ, Reagan EL Teratogenicity study of N-methylpyrrolidone after dermal application to Sprague-Dawley rats. Fundam Appl Toxicol 2-.Ti-16, 1982... [Pg.494]

Khera KS, Whalen C, Angers G Teratogenicity study on pyrethrum and rotenone (natural origin) and ronnel in pregnant rats. J Toxicol Environ Health 10 111-119, 1982... [Pg.613]

Collins TFX, Williams CH Teratogenic studies with 2,4,5-T and 2,4-D in the hamster. Bull Environ Contam Toxicol 6 559-567, 1971... [Pg.702]

A variety of cell-based and animal-based studies can be performed to ensure that a new chemical does not cause reproductive or developmental effects. A battery of tests is done to ensure that there are no harmful effects on fertility. Teratogenicity studies are performed to ensure that the chemical does not cause physical malformations in the offspring from exposure during pregnancy. Multiple generations of animals may be continuously exposed to ensure that a compound is safe. [Pg.222]

Sakemi K, Usami M, Kurebayashi H, et al. 1999. [Teratogenicity study of sodium chlorite in rats by oral administration.] Kokuritsu lyakuhin Shokuhin Eisei Kenkyusho Hokoku 117 99-103. (Japanese)... [Pg.141]

This chapter gives practical advice on how to write an effective regulatory toxicology report, with particular emphasis on embryo-toxicity, prenatal, or teratogenicity studies (see Note 2). [Pg.296]

Hansen, E. Meyer, O. (1990) Embryotoxicity and teratogenicity study in rats dosed epicuta-neously with dimethylformamide (DMF). J. appl. Toxicol., 10, 333-338... [Pg.567]

Ono, A., Sekita, K., Ohno, K., Hirose, A., Ogawa, Y, Saito, M., Naito, K., Kancko, T., Furuya, T., Matsumoto, K., Tanaka, S. Kurokawa, Y. (1995) Reproductive and develomental toxicity studies of toluene I. Teratogenicity study of inhalation exposure in pregnant rats. J. toxicol. Sci., 20, 109-134... [Pg.861]

M Usami, K Sakemi, K Kawashima, M Tsuda, Y Ohno. Teratogenicity study of stevioside in rats. Bull Nat Inst Health Sci 113 31 -35, 1995. [Pg.568]

Industrial Biotest Laboratory. 1977. Teratogenic study with monochlorobenzene in albino rats. Report to Monsanto Company, St. Louis, MO. [Pg.78]

See other pages where Teratogenicity studies is mentioned: [Pg.25]    [Pg.40]    [Pg.203]    [Pg.347]    [Pg.82]    [Pg.252]    [Pg.71]    [Pg.114]    [Pg.42]    [Pg.557]    [Pg.9]    [Pg.105]    [Pg.46]    [Pg.333]   
See also in sourсe #XX -- [ Pg.82 ]

See also in sourсe #XX -- [ Pg.128 , Pg.130 ]

See also in sourсe #XX -- [ Pg.71 ]



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