Targets transporters

Dalbey RE, von Heijne G (eds) (2002) Protein targeting, transport, and translocation. Academic Press, London... 

Prodrugs for Targeted Transport 6.2.2.1. Targeting of Intestinal Transporters... 

Extraordinary binding specificity is used in diagnostic tests targeted transport of drugs, toxins, or radioactive compounds to tumors as a cancer therapy many other applications. 

When multiple transporters participate in the membrane transport of a drug, not only the degree of inhibition of the target transporter but the contribution of the transporter to the net transport process, is taken into consideration for the prediction (Eq. 5) (2). 

The brief sketch of the requirements for gated and vesicular transport in this chapter did not take into account many complexities of the systems. But since these only make the system more intricate, they cannot ameliorate the irreducible complexity of targeted transport. 

Dalbey, R., and von Heijne, G., Eds. (2002). Protein Targeting, Transport and Translocation. Academic Press, London. 

The functioning of a cell (hepatocytes included) depends essentially on the orderly and targeted transport of molecules. This applies equally to absorption into the cell, intracellular transport, and discharge from the cell, whereby individual substances may either remain unaltered or undergo biochemical changes. The most important substances required by liver cells are water, electrolytes, trace elements, proteins, lipids, carbohydrates, bile salts, and bilirubin. The structure of the cell membrane and its functional capacities are key factors in these transport processes. (5, 15, 23, 26, 30, 37, 39, 45, 49, 50, 58, 59, 67, 68, 70, 74, 102, 106) (s.p. 27) (s. fig. 2.19)... 

Strategies for Increasing Drug Absorption Targeting Transporters... 

CESI is developing an improved water gas shift catalyst formulation that targets transportation applications with catalyst characteristics such as 1) no pre-conditioning requirement, 2) no air sensitivity, 3) preferably non-precious metal based, and 4) low sensitivity to condensed water. For the data analysis, the integral fixed bed reactor design equation was used with an empirical rate expression... 

In response to the potential intentional attacks targeting transportation infrastractnre, regulations and industry gitidance have been developed and implemented to enhance the secinity while transporting hazardous materials. While a detailed review of... 

May serve in targeted transport of localized mRNA and thus in regionalized translation (Zhao et al. 2001)... 

Glycosylation and oligosaccharide processing play an indispensable role in the sorting/ targeting/transport of proteins to their proper cellular locations and functions. Cell surface... 

H+) between feed and strip phases) is balanced by the difference of the chemical potential of the targeted transported ions. 

Douglas M. Shawn, Bachelet Ido, and Church M. George. A logic-gated nanorobot for targeted transport of molecular payloads. Science. 335 no. 6070 (2012) 831-834. 

ChEMBLdb ChEMBLdb contains freely available data on cytotoxicity and interaction with more 9000 targets including off-targets, transporters and drug-metabolizing enzymes https //www.ebi.ac.uk/chembldb/... 

As a consequence of the coupled transport of A and B ions, the target ionic species (A+ or A ) can be transported across the LM against their concentration gradient. This so-called uphill or active transport will continue until the driving force (difference of chemical potentials of B ions (usually H+) between feed and strip phases) is balanced by the difference of the chemical potentials of the targeted transported ions. 

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