Oligosaccharides processing

Figure 47-9. Schematic pathway of oligosaccharide processing. The reactions are catalyzed by the following enzymes , oligosaccharideiprotein transferase , a-glucosidase I ...

Moremen, K.W., Trimble, R. B., and Herscovics, A. (1994). Glycosidases of the asparagines-linked oligosaccharide processing pathway. Glycobiology, 4, 113-125. 

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Golgi a-l)-mannosidase II lysosomal mannosidase glycoprotein A-linked oligosaccharide processing [toxic, neurotoxic effects mimic hereditary lysosomal storage disease mannosidosis] (3-D-Glucuronidase cx-1-iduronidase Glucosidase... 

Kuznetsov, G., Brostrom, M. A Brostrom, C. O. (1993). Role of endoplasmic reticular calcium in oligosaccharide processing of Oj-antitrypsin. J. Biol. Chem. 268,2001-2008. 

VanderElst I, Dennis JW (1991) A -Linked oligosaccharide processing and autocrine stimulation of tumor cell proliferation. Exp Cell Res 192 612-621... 

Korczak B, Dennis JW (1993) Inhibition of AG inked oligosaccharide processing in tumor cells is associated with enhanced tissue inhibitor of metalloproteinases (TIMP) gene expression. Int J Cancer 53 634-639... 

Fig. 2. Oligosaccharide processing reactions occurring in the ERin mammalian cells. N, M, G, Dol, Prot, OST, GI, GII, MI, Mil, and GT stand for GlcNAc, Man, Glc, protein, dolichol, glucosidase I, glucosidase II, mannosidase I, mannosidase II, and UDP-GIc glycoprotein glucosyltransferase, respectively.

Fig. 3. Oligosaccharide processing reactions occurring the ER in T. cruzi (A) and S. cerevisiae (B). For further indications, see the legend to Figure 2.

Ziegler, F. D., Gemmill, T. R., and Trimble, R. B. (1994). Glycoprotein synthesis in yeast. Early events in AT-oligosaccharide processing in Schizosaccharomyces pombe. J. Biol. Chem. 269, 12527-12535. 

Dairaku, K., and Spiro, R. G. (1997). Phylogenetic survey of endomannosidase indicates late evolutionary appearance of this N-linked oligosaccharide processing enzyme. Glycohiology 7, 579-586. 

Su, K., Stoller, T., Rocco, J., Zemsky, J., and Green, R. (1993). Pre-Golgi degradation of yeast prepro- -factor expressed in a mammalian cell. Influence of cell type-specific oligosaccharide processing on intracellular fate. J. Biol. Chem. 268, 14301-14309. 

Yang, M., Omura, S., Bonifacino, J. S., andWeissman, A. M. (1998). Novel aspects of degradation of T Cell receptor subunits from the endoplasmic reticulum (ER) in T cells Importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes. J. Exp. Med. 187, 835-846. 

Glycosylation and oligosaccharide processing play an indispensable role in the sorting/ targeting/transport of proteins to their proper cellular locations and functions. Cell surface... 

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