ABC Transporters as Targets

In 2002, Hopkins and Groom published a study in which they estimated the number 

Attempts to apply the concept of chiral switching, that is, using dexverapamil or 

Compound Achievable in vivo concentration Optimal in vitro concentration 

Third-generation modulators of P-gp, such as tariquidar, zosuquidar, and elacridar have been developed to avoid the interference at the level of CYP P450 3A4. 

Elacridar I Malignant neoplastic disease, solid tumors 

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