Tablets binders for

Cottonseed oil has been used as a tablet binder for acetaminophen for characterization of the hot-melt fluid bed coating process in the manufacturing of stable oral pharmaceutical powders in encapsulation of enzymes and as an aqueous dispersion in pharmaceutical coating. 

PogoL [Hart Chem. Ltd.] rcGs lubricant solubilizer, antistat softener, dispersant emulsifier, humectant mold release, lubricant plasticizer, tablet binder for rubber, agric., ptqrer coat-ii s, textiles, metals, pharmaceuticals, cosmetics. 

Uses Surfactant intermediate antlstat, dye carrier, lubricant, release agent for adhesives, ceramic glazes, creams and lotions, mining, soaps and detergents, toilet bowl cleaners tablet binder for tablet coating food-pkg. adhesives and food-contset srticiss... 

Pharmaceutical Applications. Sucrose has a long history in the manufacture of pharmaceuticals. It imparts body to symps and medicinal hquids and masks unpleasant tastes. Sucrose also functions as a diluent to control dmg concentrations in medicines, as an ingredient binder for tablets, and to impart chewiness to the latter. Sustained-release medications and protective tablet glazes are prepared using sucrose (41). Sucrose-based sugar pastes are used to promote wound healing (58). 

Nunthanid, J., Laungtana-Anan, M., Sriamornsak, R, Limmatvapirat, S., Puttipipatkhachorn, S., Lim, L. Y. Khor, E. (2004). Characterization of chitosan acetate as a binder for sustained release tablets. Journal of Controlled Release, Vol. 99, 1, (September 2004), pp. (15-26), ISSN 0168-3659... 

The USP/NF provides a listing of excipients by categories in a table according to the function of the excipient in a dosage form, such as tablet binder, disintegrant, and such. An excellent reference for excipient information is the APA s Handbook of Pharmaceutical Excipients (1994). 

In section 8.3 a study is described in which the SIR of crushing strength and the SIR of disintegration time are used to evaluate batches of tablets prepared for several combinations of filler-binders and disintegrants, with respect to their physical stability after storage under tropical conditions. 

Acacia (gum arabic) is a dried gum from the stems and branches of the tree Acacia Senegal (Leguminosae/Fabaceae), abundant in the Sudan and Central and West Africa. Trees are tapped by removing a portion of the bark. The gum is used as a suspending agent, and adhesive and binder for tablets. The carbohydrate is a complex branched-chain material, which yields L-arabinose, D-galactose, D-glucuronic acid, and L-rhamnose on hydrolysis. Occluded enzymes (oxidases, peroxidases, and pectinases) can cause problems in some formulations, unless inactivated by heat. 

Hydroxy propyl methyl cellulose (HPMC).35 HPMC is a partly O-methylated and 0-(2-hydroxypropylated) cellulose available in several grades that vary in viscosity and extent of substitution. It is used widely in pharmaceutical formulations, especially in oral products, as a tablet binder, in film coating, and as controlled release matrix. Soluble in cold water, it forms a viscous colloidal solution. For a 2% aqueous solution (20°C), viscosity can range from 2.4 to 120,000 mPa-s. High-viscosity grades can be used to retard the release of water-soluble drugs from a matrix. 

There are many commercially available direct compression filler-binders. The most commonly used filler-binders include spray-dried lactose, mannitol, microcrystalline cellulose, pregelatinized starch, and dibasic calcium phosphate. Many factors affect the selection of a filler-binder for a direct compression tablet formulation. The most important requirements for a directly compressible filler-binder used in a low-dose formulation are listed below ... 

The selection of a binder for a given application remains a matter of experience. In Table 2.4, a rating is given for the effectiveness of a selection of binders and lubricants used in the tableting of different materials. Other reviews of binder systems used in fuel briquetting [43], ceramic [45], pharmaceutical [39,46] and foundry [47] applications are available. 

Gum Arabic Pharmaceutical tablet binder Adhesive for miscellaneous paper 15... 

An example looking at a new application of inulin (Figure 14-2). Inulin is a polysaccharide obtained from chicory roots. It is a foodstuff with the interesting properties sweet, nonfattening and healthy. Although it sells well in the food industry, the company is looking for other markets. The question to be answered by a team of three students is could we use inulin as a filler-binder for pharmaceutical tablets ... 

Test the solubility of your sample in toluene and in hot water and note the peculiar character of the aqueous solution when it is cooled and when it is then rubbed against the tube with a stirring rod. Note also that the substance dissolves in cold sodium bicarbonate solution and is precipitated by addition of an acid. Compare a tablet of commercial aspirin with your sample. Test the solubility of the tablet in water and in toluene and observe if it dissolves completely. Compare its behavior when heated in a melting point capillary with the behavior of your sample. If an impurity is found, it is probably some substance used as binder for the tablets. Is it organic or inorganic To interpret your results, consider the mechanism whereby salicylic acid is acetylated. 

Schmidt, P.C. Brogmann, B. Effervescent tablets choice of a new binder for ascorbic acid. Acta Pharm. Technol. 1988, 34, 22-26. 

Pesonen, T. Paronen, P. Puurunen, T. Evaluation of a novel cellulose powder as a filler-binder for direct compression of tablets. Pharm. Weekbl. Sci. Ed., 1989,11, 13-19. 

Carboxymethylcellulose sodium is widely used in oral and topical pharmaceutical formulations, primarily for its viscosity-increasing properties. Viscous aqueous solutions are used to suspend powders intended for either topical application or oral and parenteral administration. Carboxymethylcellulose sodium may also be used as a tablet binder and disin-tegrant, and to stabilize emulsions. ... 

Cellulose acetate phthalate (CAP) is used as an enteric film coating material, or as a matrix binder for tablets and capsules.Such coatings resist prolonged contact with the strongly acidic gastric fluid, but dissolve in the mildly acidic or neutral intestinal environment. 

Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-... 

Moroni A. A novel copovidone binder for dry granulation and direct-compression tableting. Pharm Tech 2001 25 (Suppl.) 8-24. 

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