Binder for tablets, granulates and hard gelatin capsules

Binder for tablets, granulates and hard gelatin capsules 

The main area of application of copovidone is as a binder in tablets and granules (including granules for hard gelatin capsules), regardless of whether they are made by wet or dry granulation or by direct compression (see Fig. 36 in Section 2.4.2.1), as it is equally effective in all three cases. It can also be used in extrusion [465] or in cocrystallization [463]. 

The usual concentration in which copovidone is used as a binder in tablets and granules lies between 2% and 5%. This range is similar to that of povidone K 30 in tablets. 

Granulation is still the most frequently used method of preparing a tabletting mixture. There are at least four different variations of the procedure (Table 172). 

Water is nowadays the most commonly used solvent. Sometimes, if water cannot be used, as with effervescent tablets, active ingredients that are prone to hydrolysis etc., ethanol or isopropanol are used as solvents, though fluidized bed granulation is preferred. 

---

Binders for tablets, granules and hard gelatin capsules... 

---