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Dissolution-controlled drug delivery

Dissolution, of viscose, 11 254-255 Dissolution-controlled drug delivery, degradation/ erosion-based drug delivery systems, 9 11-19 Dissolution inhibition, by... [Pg.282]

Chapter 5. Dissolution Controlled Drug Delivery Systems... [Pg.445]

Fig. 17 Syncro-Mate-C implant, a subdermal implant fabricated from the microreservoir dissolution-controlled drug-delivery system, and subcutaneous controlled release of nor-gestomet, a potent synthetic progestin, at constant rate for 20 days. The open ends on the implant do not affect the zero-order in vivo drug release profile. (Adapted from Ref. . )... Fig. 17 Syncro-Mate-C implant, a subdermal implant fabricated from the microreservoir dissolution-controlled drug-delivery system, and subcutaneous controlled release of nor-gestomet, a potent synthetic progestin, at constant rate for 20 days. The open ends on the implant do not affect the zero-order in vivo drug release profile. (Adapted from Ref. . )...
Fig. 2 Two types of dissolution-controlled, pulsed delivery systems (A) single bead-type device with alternating drug and rate-controlling layers (B) beads containing drug with differing thickness of dissolving coats. Fig. 2 Two types of dissolution-controlled, pulsed delivery systems (A) single bead-type device with alternating drug and rate-controlling layers (B) beads containing drug with differing thickness of dissolving coats.
The majority of controlled drug delivery systems now being marketed or under development are based on diffusion of the drug through a semipermeable membrane to achieve the requisite release rate. Diffusion control is particularly important to transdermal delivery, where biodegradation and dissolution are not viable mechanisms of controlling the release rate. Provided the process is Fickian, the rate of diffusion through the semipermeable polymer is determined by... [Pg.49]

Siepmann, J., Kranz, H., Bodmeier, R., and Peppas, N., HPMC-matrices for controlled drug delivery A new model combining diffusion, swelling, and dissolution mechanisms and predicting the release kinetics, Pharmaceutical Research, Vol. 16, No. 11, 1999, pp. 1748-1756. [Pg.388]

Fassihi, R.A. McPhillips, A.M. Uraizee, S.A. Sakr, A.M. Potential use of magnesium stearate and talc as dissolution retardants in the development of controlled drug delivery systems. Pharm. Ind. 1994, 56 (6), 579-583. [Pg.1745]

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