Controlled drug delivery system magnetic

Among the controlled drug delivery systems, pH-sensitive system has a special interest in view of the fact that both extracellular tumor (pH 6.8) and endosomes (pH 5.5) are more acidic than normal tissues (pH 7.4). The physical stimuli, such as temperature, or magnetic field will affect the level of various energy sources and alter molecular interactions at critical points. Treating the synthesized microspheres under the above environments can affect their behavior via the interactions of the polymeric chains. 

Hsieh, D.S.T. Langer, R. Zero-order drug delivery systems with magnetic control. In Controlled Release Delivery Systems Roseman, T.J., Mansdorf, S.Z., Eds. Marcel Dekker, Inc. New York, 1983. 

Morphology control is indispensable in many of the advanced applications envisioned for functional mesoporous materials (54, 267). Permselective membranes, micro-spheres, or monoliths are important for sorption, separation, and chromatography purposes. Porous thin films or fibrous structures are relevant for electronics, optics, low fe-dielectrics, and sensing applications. Colloidal particles or nanospheres are preferred for biomedical systems to be used in drug delivery or magnetic resonance imaging (MRl) with contrast agents. 

Reservoir-Based MEMS Drug Delivery System, Fig. 4 A magnetically controlled MEMS device for on-demand and controlled drug delivery. Uprai application of a magnetic field ( 250 mT), the membrane... 

Giani, G., Fedi, S., Barbucci, R., 2012. Hybrid magnetic hydrogel a potential system for controlled drug delivery by means of alternating magnetic fields. Polymers 4,1157—1169. 

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