Dosing considerations

Welling, P.G. Deobrinska, M.R. "Dosing considerations and bioavailability assessment of controlled drug delivery systems" In Controlled Drug Delivery Robinson, J.R., Lee, V.H.L., Eds. Drugs and the Pharmaceutical Sciences M. Dekker, New York, NY, 1987, Vol. 29, pp. 253-292. 

B. Dosing Considerations Determined by Alterations in Physiology with Aging... 

M. Danish and S. Rosenbaum, Dosing considerations for non-prescription drugs in infants and children, Clin. Res. Regul. Affairs, 9, 89 (1992). 

In routine inhalation studies, it is generally accepted that the respiratory parameters are relatively constant when the animals are similar in age, sex, and body weight. This leaves only C and t to be the major variables for dose consideration. 

General dosing considerations It is recommended that lamotrigine not be restarted... 

Hirsch J,Warkentin TE, Raschke R, Granger C, Ohman EM, Dalen JE Heparin and low-molecular-weight heparin mechanisms of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. Chest (1998) 3 34 489S-510 S. 

X-ray diffraction imaging in its early days followed a similar path to target medical diagnostic applications. Several investigators found remarkable differences between the diffraction profiles of healthy and diseased tissue in the skeleton [11] and breast [12], to name just two examples. Dose considerations however, particularly compared with MRI, have prevented up to now the widespread application of XDI in diagnostic radiology. 

As a matter of fact, all dissolution studies, which invariably rely on (5.1) and do not make dose considerations, utilize (5.15) for the calculation of the MDT. However, the previous equation applies only when the entire available amount... 

Body weights and surface area are considered in dose selection (see Table 38.4). A variety of physiological parameters are also considered in dose considerations. (see Table 38.5 through 38.8)... 

Use of doses considerably higher than those found to be active in pharmacological tests for the proposed indication. If possible, doses at least 10 times higher were used. 

Welling, P. G., and Dobrinska, M. R. (1987), Dosing considerations and bioavailability assessment of controlled drug delivery systems, in Controlled Drug Delivery Fundamentals and Applications, Marcel Dekker, New York, pp. 253-289. 

Political and scientific attention has recently turned towards investigating substances that possess hormonal activity or alter patterns of hormone effects. Not only does detecting such changes in organisms prove to be extremely complicated, these endocrine disruptors can be active at very low doses. Considerable work for the standardisation of endocrine disruptor test methods has been undertaken at EU and international levels, but there is currently little agreement on how to test for such effects [123]. 

In accord with this expectation, a first-generation water-soluble texaphyrin 10.1 (Figure 10.1.2) was found to show an exceptionally high relaxivity in aqueous medium (/ i = 16.9 1.5 mM s 50 MHz room temperature).At the time it was obtained, this important result was considered to augur well for the in vivo usefulness of 10.1 it meant that high efficacy could be expected at doses considerably lower than those required for more conventional, carboxylate-derived gadolinium(III) chelates. 

HUMAN TOXICOLOGY OF ANTICHOLINERGIC COMPOUNDS DOSING CONSIDERATIONS Atropine... 

Kaunitz AM. Oral contraceptive estrogen dose considerations. Contraception 1998 58 15S-21S. 

Underlying disease states that may affect antibiotic metabolism and/or elimination should be considered when developing a prophylactic regimen. For example, patients with thermal burn and spinal cord injuries eliminate certain classes of antibiotics, primarily the aminoglycosides and /3-lactams, at unusually high rates compared with controls. Individuals undergoing cardiac bypass may have altered antibiotic disposition related to increased volume of distribution and reduced total-body clearance and thus require special dosing consideration. ... 

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