Symptoms of Intolerance

In a further move to achieve a high degree of consumer protection and to provide adequate information, the Commission is addressing the issue of specific identification of substances in food that cause allergies and symptoms of intolerance and hypersensitivity in certain consumers. A proprosed Directive19 will require declaration of these substances (listed in Annex Ilia) under all... 

The rationale for the need of recovery animals was frequently discussed. For drag substances which require chronic (live time) treatment (e.g. oral anti-diabetics, drags for treatment of hypertension, anti-Parkinson drugs, etc.) the question of recovery is less important than in the case of anti-infectives with, in most cases, short treatment periods where mild symptoms of intolerance, e.g. diarrhoea, are observed. However, inclusion of recovery animals is recommended in general because at the stage of development where first clinical studies are conducted, the whole set of indications is not finally known and line extensions can happen. One example is the use of quinolones and other anti-infectives for the treatment of cystic fibrosis. Another example is drugs used for chemotherapy of malignant diseases where recovery has to be studies anyway. 

Approximately 10-20% of lactose-intolerant individuals, in two studies, showed clinical symptoms of intolerance after ingestion of 3-5 g of lactose.In one of the studies, 75% of the subjects had symptoms with 12 g of lactose (equivalent to 250 mL of milk). In another, eight out of 13 individuals developed diarrhea after the administration of 20 g of lactose, and nine out of 13 after the administration of 25 g. 

As a rule, allopurinol fulfills this purpose. However, it is not unusual to find that there are situations where allopurinol cannot be utilized because it can lead on the one hand to symptoms of intolerance. On the other hand, sometimes the desired decrease of the serum uric acid cannot be obtained despite increased doses. 

A much more common metabolic disorder, lactose intolerance, occurs commonly in most parts of the world (notable exceptions being some parts of Africa and northern Europe). Lactose intolerance is an inability to digest lactose because of the absence of the enzyme lactase in the intestines of adults. The symptoms of this disorder, which include diarrhea and general discomfort, can be relieved by eliminating milk from the diet. 

The symptoms of hypothyroidism maybe confused with symptoms associated with aging, such as depression, cold intolerance, weight gain, confusion, or unsteady gait. The presence of these symptoms should be thoroughly evaluated and documented in the preadministration assessment and periodically throughout therapy. 

There are three common protocols for barbiturate detoxification. In all approaches, the goal is to prevent the occurrence of major symptoms and to minimize the development of intolerable minor symptoms. The first procedure is based on protocols described by several authors (Ewing and BakeweU 1967 Isbell 1950 Wilder 1968) (see Table 3 ). The first step is to determine the severity of tolerance. If the patient is intoxicated, no additional barbiturate should be given until the symptoms of intoxication have resolved. If there is substantial evidence or strong suspicion of chronic barbiturate use, it is not necessary or desirable to wait until withdrawal symptoms appear. A 200-mg oral dose of pentobarbital may be given on an empty stomach to a... 

AIA runs a characteristic clinical course [9]. It is more frequent in women than men, and is unusual in children, beginning in adulthood, on average at the age of 30 years. Rhinorrhea and nasal congestion are usually the first symptoms, subsequently complicated by polyposis. Asthma and aspirin hypersensitivity develop 2-15 years later. Once developed, aspirin intolerance remains through life, although sporadic disappearance of intolerance has been reported. Asthma, characterized by blood and nasal eosinophilia, rims a protracted course despite avoidance of analgesics. In about half the patients, the course of asthma is severe, necessitating use of systemic corticosteroids. 

Monitor for adverse effects of 3-blockers—heart rate, blood pressure, fatigue, masking of symptoms of hypoglycemia and/or glucose intolerance (in patients with diabetes), wheezing or shortness of breath (in patients with asthma or chronic obstructive pulmonary disease), etc. 

Anemia of CKD is associated with symptoms of cold intolerance, shortness of breath, and decreased exercise capacity. 

Since many AR treatment options are available OTC, patients often self-treat unless symptoms are intolerable. Additionally, patients without medical insurance or formulary coverage are more likely to purchase OTC agents. Health care providers should ask patients about OTC medication history (i.e., effectiveness of and adverse effects with previously used agents) when selecting AR therapy. 

An evaluation of the rifaximin tolerability profile observed in almost 1,000 patients from 30 clinical trials was unable to identify a definite pattern of intolerance [33]. Very few adverse events have been reported during short-tem treatment with the drug, the most frequently reported being gastrointestinal in nature (e.g. flatulence, nausea, abdominal pain and vomiting). It is worthwhile to emphasize that the detection of GI adverse reactions could have been difficult in rifaximin trials since the symptoms of the underlying diseases were often similar to the GI complaints observed after drug treatment. 

After an ACS, patients should receive a /1-blocker indefinitely, regardless of whether they have residual symptoms of angina. Therapy should continue indefinitely in the absence of contraindications or intolerance. 

Symptoms of thyrotoxicosis include nervousness, anxiety, palpitations, emotional lability, easy fatigability, heat intolerance, loss of weight concurrent with an increased appetite, increased frequency of bowel movements, proximal muscle weakness (noted on climbing stairs or arising from a sitting position), and scanty or irregular menses in women. 

Candida albicans, C. tropicalis, C parapsilosis and resolution of signs and symptoms of infection Remove existing central venous catheters when feasible, plus Amphotericin B IV 0.6 mg/k day or Fluconazole IV/po 6 mg/kg/day or An echinocandin or Amphotericin B IV 0.7 mg/kg/day plus fluconazole IV/po 800 mg/day Patients intolerant or refractory to other therapf Amphotericin B lipid complex IV 5 m k day Liposomal amphotericin B IV 3-5 mg/kg/day Amphotericin B colloid dispersion IV 2-6 mg/k day (continued)... 

In humans concentrations of 159ppm and 48 ppm have been reported as fatal after 10 min and 30min, respectively. A concentration of 20 ppm was considered intolerable after 1 minute, and Ippm for 10 minutes was irritating. Symptoms of exposure include severe irritation of the eyes and respiratory tract, with hemorrhagic exudate of the bronchi and trachea and pulmonary edema. Repeated exposures may also cause dizziness, loss of appetite, mental deterioration, and weight loss. ... 

Adverse effects are usually due to excessive doses (which may occur if the initial increase in metabolism is too rapid) and correspond to symptoms of hyperthyroidism, but they usually disappear after dose reduction or withdrawal of treatment. The most common adverse effects affect the following system as Heart arrhythmias, anginal pain, Central nervous system headache, hyperactivity, sweating, tremor, heat intolerance, Gastrointestinal tract diarrhoea, excessive weight loss, vomiting, Musculoskeletal system muscle cramps, muscle weakness. 

In adults, the signs and symptoms of hypothyroidism include somnolence, slow mentation, dryness and loss of hair, increased fluid in body cavities (e.g., the pericardial sac), low metabolic rate, tendency to gain weight, hyperlipidemia, subnormal temperature, cold intolerance, bradycardia, reduced systolic and increased diastolic pulse pressure, hoarseness, muscle weakness, slow return of muscle to the neutral position after a tendon jerk, constipation, menstrual abnormalities, infertility, and sometimes myxedema (hard edema of subcutaneous tissue with increased content of proteoglycans in the fluid). A goiter (i.e., enlargement of the thyroid gland) may be present. 

The most common adverse effects (i.e., symptoms of hyperthyroidism) are the result of a drug overdose they include cardiac palpitation and arrhythmias, tachycardia, weight loss, tremor, headache, insomnia, and heat intolerance. Symptoms subside if medication is withheld for several days. 

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