Sustainable pharmaceuticals

Given the data challenges discussed previously and the increasing use of streamlined methods, it is necessary to continuously improve the consistency and transparency of the information and the assumptions used in such tools to ensure the quality and the validity of the decisions made with the aid of LGA metrics. The inclusion of quality indicators (such as sensitivity and uncertainty analysis) will continue to be an important step to estimate the uncertainties involved in the inventory and impact models. Finally, there is a need to continuously perform peer review assessments by LGA experts, as the current LGA expertise in pharmaceuticals is very limited. When these requirements are fulfilled, LGA metrics are powerful tools to aid the decision making leading to more sustainable pharmaceutical processes. For further examples of FLASG scores and other LGA analyzes being applied, see Section 10.4.1. 

In order to invest sustainably, pharmaceutical companies also need access to a large and effectively regulated market in which returns can be... 

Domingo C, Saurina J (2012) An overview of the analytical characterization of nanostruc-tured drug delivery systems towards green and sustainable pharmaceuticals a review. Anal Chim Acta 744 8-22... 

Cosmetics and Pharmaceuticals. The main use of hexadecanol (cetyl alcohol) is in cosmetics (qv) and pharmaceuticals (qv), where it and octadecanol (stearyl alcohol) are used extensively as emoUient additives and as bases for creams, Hpsticks, ointments, and suppositories. Octadecenol (oleyl alcohol) is also widely used (47), as are the nonlinear alcohols. The compatibiHty of heavy cut alcohols and other cosmetic materials or active dmg agents, their mildness, skin feel, and low toxicity have made them the preferred materials for these appHcations. Higher alcohols and their derivatives are used in conditioning shampoos, in other personal care products, and in ingested materials such as vitamins (qv) and sustained release tablets (see Controlled RELEASE technology). 

Pharmaceutical Applications. Sucrose has a long history in the manufacture of pharmaceuticals. It imparts body to symps and medicinal hquids and masks unpleasant tastes. Sucrose also functions as a diluent to control dmg concentrations in medicines, as an ingredient binder for tablets, and to impart chewiness to the latter. Sustained-release medications and protective tablet glazes are prepared using sucrose (41). Sucrose-based sugar pastes are used to promote wound healing (58). 

There are multiple mechanisms known to underlie the neuronal cell damage associated with injury or disease that at least theoretically could be targeted for pharmaceutical intervention. Currently however, there is no clinically available therapeutic agent that can reliably protect the brain from progressive neurodegenerative processes for sustained periods. Due to the extensive amount of preclinical research that has been conducted in recent years, there is a basis for optimism, however, it appears likely that some of these approaches will result in clinically effective therapeutic modalities in the near future. A short overview of some of the investigational approaches to combat neurodegeneration appears below. 

The need of modern science to achieve a sustainable future development has been shown in many circumstances in society. Finding strategies less harmful to the environment has been a quest for research in several areas, such as pharmaceuticals, biotechnology, and food industries. With that purpose, the increase in research and development of more applications of xylan and its derivatives has shown the versatility of this biopolymer, thus helping the search for sustainable alternatives. 

As a consequence of all the aforementioned issues, the pharmaceutical industry cannot reasonably sustain its historic double-digit growth without... 

Sheng H, Wang P, Tu J.-S, Yuan L, Pin Q-N. Applications of artificial neural networks to the design of sustained release matrix tablets. Chinese J Pharmaceut 1998 29 352-4. 

With one exception, all the chapters from the third edition of Modern Pharmaceutics that appear in the fourth edition have been revised and updated. Many chapters were extensively updated, and some, such as the first and last chapters, were extensively rewritten. Due to the illness of Dr. Robinson, the chapter on sustained and controlled release drug delivery systems was updated with the assistance of Gil Banker, with Dr. Robinson s approval. 

Some tablets combine sustained-release and rapid disintegration characteristics. Products such as K-Dur (Key Pharmaceuticals) combine coated potassium chloride crystals in a rapidly releasing tablet. In this particular instance, the crystals are coated with ethylcellulose, a water-insoluble polymer, and are then incorporated into a rapidly disintegrating microcrystalline cellulose (MCC) matrix. The purpose of this tablet is to minimize GI ulceration, commonly encountered by patients treated with potassium chloride. This simple but elegant formulation is an example of a solid dosage form strategy used to achieve clinical goals. 

IPs are very useful for DDS because IP systems allow easy entrapment of pharmaceuticals and bioactive agents and can be used as a depot for their sustained release after a simple injection with a syringe at the target site in a human body. Such a system can minimize the requirement for surgical operations for... 

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