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Sulphonamides, detection

Reduction to S(IV) is the basis of two spot tests of Feigl, although these apply to other S(VI) classes, e.g. sulphonamides. Thus Feigl and Lenzer fused the sample with alkali to yield sulphite, then treating with hydrochloric acid and warming to expel sulphur dioxide they detected the latter with nickel(II) hydroxide on test paper, which yielded ultimately the black Ni(IV) oxyhydrate (see also Section C). In the other test FeigF fused the sample with sodium formate/alkali, cooled and acidified with sulphuric acid to liberate sulphur dioxide in this case also. This was detected by a ferric chloride/potassium ferricyanide reagent which yielded a blue colour (Prussian, Turnbull s). [Pg.108]

ESI operating in the negative ion (Nl) mode has been the interface most widely used for the analysis of anionic PFCs. In addition, ESI has also been optimized for the determination of neutral compounds, such as the sulphonamides PFOSA, Et-PFOSA, and t-Bu-PFOS. The use of atmospheric pressure photoionization (APPI) has been explored by Takino and collaborators [88]. The authors found the main advantage of this technology to be the absence of matrix effects, but the limits of detection were considerably higher than those obtained by LC-ESTMS/MS. [Pg.19]

Hartig C, Storm T, Jekel M (1999). Detection and identification of sulphonamide drugs in municipal wastewater by liquid chromatography coupled with electrospray ionisation tandem mass spectrometry. J Chromatography A 854 163-173 Hayes HM, Tarone RE, Cantor KP (1995) On the association between canine mahgnant lymphoma and opportunity for exposure to 2,4-dichlorophenoxyacetic acid. Environ Res 70 119-125... [Pg.380]

The HPLC-receptorgram assay combined the advantages of HPLC separation with the multiresidue detection of the Charm II tests. The procedure was tested for identification and quantitation of the most common veterinary drugs at regulatory levels or lower. It was validated for 40 individual drugs from seven antibiotic families 10 /3-lactams, 13 sulphonamides, 8 tetracyclines, 4 macrolides, 3 amphenicols, and other miscellaneous antimicrobials. This procedure combined a simple aqueous extraction and SPE with HPLC fractionation of individual drugs. Final identification and quantitation was achieved with the Charm II test. A drug contaminant could be identified in less then 3 hours (50). [Pg.631]

TA Gehring, LG Rushing, HC Thompson. Determination of sulphonamides in edible salmon tissue by liquid chromatography with postcolumn derivatization and fluorescence detection. J AOAC Int 80 741-755,1997. [Pg.688]

The neutral sulphur compounds include sulphides or thioethers, disulphides, sulphoxides and sulphones, sulphate and sulphonate esters, and isothiocyanates. Acidic sulphur compounds, i.e. sulphonic and sulphinic acids, thiols and thio-phenols, and the primary sulphonamides have already been discussed. The sulphates of amines are converted by aqueous sodium hydroxide into the free bases the sulphate anion can be detected in the resulting aqueous solution as barium sulphate in the usual manner. [Pg.1231]

Most recently, a further study has been performed using superheated-water HPLC with NMR and MS to analyse a mixture of sulphonamides [68]. The chromatography was performed as before with D20-phosphate buffer (pD 3.0) as eluent. A temperature gradient from 160 to 200 °C at 2°C min-1 was employed. A mixture of four sulphonamides, i.e. sulacetamide, sulphadiazine, sulfamerazine and sulfamethazine, was separated in this system with UV, NMR and MS detection. It rapidly became clear from a study of the spectroscopic data that while sulfacetamide and sulfadiazine gave the expected NMR and mass spectra, those for sulfamerazine and sulfamethazine did not. These compounds gave spectra that were 3 and 6 mass units higher than expected,... [Pg.80]

Although sensitising properties can be also detected in the classical development program of a drug substance, the need for dermal sensitization studies is of importance for the development of certain drugs. The increasing importance of trans-dermal formulations demonstrate the need of testing for dermal sensitization on the one side, on the other side, there are classical examples which cause dermal sensitization (e.g. neomycin, procaine, sulphonamides). [Pg.795]

Interference may arise from the presence of benzodiazepines these are hydrolysed to amino-benzophenones which also undergo diazotisation. Sulphonamides are also detected by this procedure, and can be distinguished by either of two methods. The unhydrolysed plate may be sprayed with Van Urk reagent, then heated at 100° for 5 minutes. This gives yellow colours with sulphonamides but not with thiazides. Alternatively, hydrolysed extracts of urine and of reference solutions can be chroma-tographed by the following procedure. [Pg.32]

Copper sulphate solution. This detects V-substituted sulphonamides. [Pg.176]

Cure system species, accelerators and their reaction products This class of additive can present problems as they are often thermally labile, reactive and, in some cases, have a degree of ionic character (e.g. zinc dithiocarbamate salts). In these cases LC-MS is a more appropriate technique than GC-MS. It is also easier to use LC-MS with a number of the approved food simulants as they can be injected directly into the instrument, being compatible with the mobile phase. In some cases the reaction products (e.g. aniline from diphenyl guanidine, and benzothiazole from thiazole and sulphonamide accelerators) are stable and so GC and GC-MS can be used. Peroxides are popular curatives for food use rubbers and the stable, breakdown products of these can be easily detected by GC-MS. [Pg.287]

C. Hartig, T. Storm, M. Jekel, Detection and identification of sulphonamide drugs in municipal waste water by LC-ESI-MS-MS, J. Chromatogr. A, 854 (1999) 163. [Pg.230]

Determination of sulphonamides by liquid-chromatography, ultraviolet diode-array detection and ion-spray tandem mass-spectrometry with application to cultured salmon flesh. J. Chromatogr. 1991, 558, 155-173. [Pg.551]

Hydrolysis is a standard procedure for determining carboxamides. Alkaline hydrolysis yields ammonia or an amine which can usually be distilled out and easily detected or determined, e.g. by titration with acid. This method can be applied to sulphonamides, usually under rather more vigorous conditions359,360. Acid hydrolysis is also possible the solution can then be made alkaline and the ammonia or amine distilled and determined as after alkaline hydrolysis361. In another published work, the sulphonic acid product was isolated, e.g. by using an ion exchanger, and titrated with alkali362. [Pg.337]


See other pages where Sulphonamides, detection is mentioned: [Pg.1077]    [Pg.108]    [Pg.1077]    [Pg.222]    [Pg.19]    [Pg.28]    [Pg.29]    [Pg.38]    [Pg.348]    [Pg.359]    [Pg.365]    [Pg.1077]    [Pg.660]    [Pg.1214]    [Pg.4]    [Pg.137]    [Pg.144]    [Pg.397]    [Pg.1214]    [Pg.272]    [Pg.115]    [Pg.990]    [Pg.385]    [Pg.148]    [Pg.365]    [Pg.108]    [Pg.1077]    [Pg.173]    [Pg.198]    [Pg.336]    [Pg.336]    [Pg.336]    [Pg.337]   
See also in sourсe #XX -- [ Pg.543 ]




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