Benzophenone, 4-Amino

Benzophenone, 2-amino, 32, 8 THIO-, 35, 97 Benzopyrazole, 39, 27 -Benzoquinone, 35, 26 Benzoylacetanilide, 37, 2 Benzoylacetic acid, ethyl ester,... 

Amino-5-chlorobenzophenone Benzophenone, 2-amino-5-chloro- (8) Methanone, (2-amino-5-chlorophenyl)phenyl- (9) (719-59-5)... 

Oxazepam and related compounds are converted by extractive alkylation into N,0-dimethyl derivatives and are analysed on 3% of OV-225 at 250°C [550]. Another procedure involves the extraction of the sample with benzene, hydrolysis with a strong acid and acylation of the benzophenone amino derivative produced with TFA anhydride [551], Extractive alkylation is used to advantage also for other pharmaceuticals, especially for their determination in plasma, urine and other biological materials. By this procedure hydrochlorothiazide was analysed in plasma, blood corpuscules and urine [552], furosemide in plasma [553] and chlorthalidone and related drugs in plasma and other biological samples [554,555],... 

Pis commonly have been synthesized from reactions of pyromellitic dianhydride [26265-89-4] (PMD A) or 3,3H,4 -benzophenone tetracarboxyUc dianhydride [2421-28-5] (B IDA) with a number of diamines like 2,2-bis(4-aminophenyl)propane, 2,2-bis(4-amino-3-methylphenyl)propane, I,I-bis(4-aminophenyl)-I-phenylethane, and 1,1-his(4-amino-3-methy1pheny1)-1-phenylethane (5). The PMDA-based Pis were thermally more stable than the corresponding Pis obtained from BTDA. 

Photolysis in concentrated HCl of 3,5-diphenyl-2,l-benzisoxazole gave 2-amino-3-chloro-5-phenylbenzophenone and 2-amino-5-(p-chlorophenyl)benzophenone via similar intermediates (Scheme 20) (71HCA2111). 

The derivative of glycine, prepared from benzophenone (cat. BF3 Et20, xylene, reflux, 82% yield), has found considerable use in the preparation of amino acids. It can also be prepared by an exchange reaction with benzophenoneimine (Ph2C=NH, CH2CI2, rt). ... 

Methylimidazole HCI 2-Amino-5-chloro-2 -fluoro-benzophenone Ethyl aminomalonate hydrochloride... 

A) 1-(2-Amino-5-chlorophenyll-1-(2-fluorophenyll-2-a2a-but-1-en-4-ol A mixture of 40 g of 2-methylimidazole hydrochloride and of 90 g of 2-amino-5-chloro-2 -fluoro-benzophenone in 240 ml of ethanolamine is heated at 135 for 2 hours. After cooling, the reaction mixture is poured into an aqueous sodium bicarbonate solution. The mixture is extracted with ether, the organic phase is washed repeatedly with water and is dried over sodium sulfate, and the solvent is evaporated to dryness. The residual oil is chromatographed on a silica column, elution being carried out with a 50/50 mixture of cyclohexane and ethyl acetate. 

Preparation of 2-Cyc/opropy/methy/amino-5-Ch/orobenzophenone To a solution of 315 g (1.09 mols) of 2-cyclopropylmethylamino-5-chloroDenzhydrol in 4 liters of benzene is added 453.6 g (5.22 mols) of manganese dioxide, freshly prepared according to the method of Attenburrow et al, J.C.S. 1952, 1104. The mixture is then refluxed for VA hours, filtered, and the filtrate evaporated under vacuum. The reddish residue is recrystallized from 510 ml of 90% acetone-10% water, giving 181 g of pure 2-cyclopropylmethylamino-5-chloro-benzophenone, MP 79° to 80°C (58% yield). Upon concentration of the mother liquor a second crop of 2-cyclopropylmethylamino-5-chlorobenzophenone weighing 34.1 g and melting at 76.5°-78°C are obtained. 

A further variant of Method B is the acylation of a 2-aminobenzophenone with a protected a-amino acid chloride, followed by conversion of the product 11 into the 2-(aminoacet-amido)benzophenone 12 by reaction with hydrobromic acid in acetic acid.196... 

A mixture of 5-chloro-2-[chloroacetyl(mcthyl)amino]benzophenone (1.136 g, 3.1 mmol), hexamethylenetetramine (1.0 g, 7 mmol) and EtOH (15 mL) was heated under reflux for 10 h. The solvent was distilled off under reduced pressure, H20 (10 mL) was added to the residue and the mixture was extracted with benzene (3 x 10 mL). The combined extracts were washed with H20, dried (Na2S04) and evaporated in vacuo. Crystallization the residue (Et2Q) gave the product yield 0.79g (80%) mp 128-130 C. 

Unter ahnlichen Bedingungen wird 2,2 -Dinitro-benzophenon reduktiv zu Azobenzol und 2-Amino-benzyl-alkohol gespalten4. 

Diphenyl-diazomethan liefert bei der Elektrolyse an Platin in DMF/Tetrabutylammo-niumperchlorat Diphenylmethan, Amino-diphenyl-methan und Benzophenon-azin. Bei hohcn negativen Potentialen (—1,9 bis —2,2 V) und niedriger Ausgangskonzentration iiberwiegt Diphenylmethan (bis 51% d.Th.) das Azin dominiert erwartungsgemaB bei... 

Titanium(III) chloride (particularly in slightly alkaline medium) reduces the p-nitro groups of the thiophosphate insecticides to amino groups, which are then reacted with nitrite in acid mediiun in a second step to yield a diazonium compound as intermediate. This is then coupled to N-(l-naphthyl)-ethylenediamine dihydrochloride to yield an azo dye [3]. In the case of benzodiazepines the first reaction step includes an additional acid hydrolysis to the corresponding benzophenone derivative [2]. 

More recently, catalytic asymmetric allylations of imines and imine derivatives in aqueous media have been studied. An /V-spiro C2-symmetrical chiral quaternary ammonium salt (5,5)-I-Br (,S, .S )-()-Np-NAS-Br] has been evaluated in the allylation of glycine tert-Bu ester benzophenone Schiff base [Ph2C=NCH2COOCMe3] for synthesis of both natural and unnatural a-amino acids (Eq. 11,45).76... 

Benzonitrile, 2,6-dimethoxy-, 22, 35 Benzophenone, 23, 99 Benzophenone azine, 24, 55 Benzophenone hydrazone, 24, 54 Benzopyrrole, 23, 42 Benzothiazole, I-amino-5-methyl-,... 

Stony Brook synthesized a photoreactive benzophenone containing inhibitor (39, Fig. 14) which efficiently labeled the active site of the enzyme. The photoinhibition was prevented by adding native Ras to the reaction mixture. That competition indicated that the labeling was specific at the active site. Peptide mapping of the labeled enzyme by HPLC, Edman sequencing and MALDI-MS allowed the identification of key amino acids in the substrate binding, as Asp-110 and Asp-112 in the a-subunit [126]. 

Preparative photolysis of AETSAPPE (0.25 M aqueous solution) at 254 nm (Rayonet reactor) resulted in the formation of the disulfide product 2-amino(2-hydroxy-3-(phenyl ether) propyl) ether disulfide (AHPEPED) as the primary photoproduct Photolysis of AETSAPPE at 254 nm (isolated line of medium pressure mercury lamp) resulted in rapid initial loss of starting material accompanied by formation (analyzed by HPLC) of AHPEPED (Figure 12a and 12b) (Scheme IV). Similar results were obtained for photolysis- at 280 nm. Quantum yields for disappearance of AETSAPPE and formation of AHPEPED at 254 nm and 280 nm are given in Table I. The photolytic decomposition of AETSAPPE in water was also accomplished by sensitization ( x =366 nm) with (4-benzoylbenzyl) trimethylammonium chloride (BTC), a water soluble benzophenone type triplet sensitizer. The quantum yield for the sensitized disappearance (Table I) is comparable to the results for direct photolysis (unfortunately, due to experimental complications we did not measure the quantum yield for AHPEPED formation). These results indicate that direct photolysis of AETSAPPE probably proceeds from a triplet state. 

---