Electrospray-ionisation

For off-bead analysis, coupling between chromatographic separation and mass spectrometric detection has proven especially powerful. The combination between high performance liquid chromatography (HPLC) and electrospray ionisation mass spectrometry has the advantage that purity of product mixtures can be coupled on-line with the product identification. [Pg.383]

Kasprzyk-Hordern B, Dlnsdale RM, Guwy AJ (2007) Multi-residue method for the determination of basic/neutral pharmaceuticals and illicit dmgs in surface water by solid-phase extraction and ultra performance liquid chromatography-positive electrospray ionisation tandem mass spectrometry. J Chromatogr A 1161 132-145... [Pg.226]

Yoder R (2003) Electrospray ionisation mass spectrometer study ofdioctyitin compounds in solution. Report provided to Risk Policy Analysts Ltd by the European Tin Stabilisers Association, May. [Pg.52]

Hvattum, E., Determination of phenolic compounds in rose hip (Rosa canina) using liquid chromatography coupled to electrospray ionisation tandem mass spectrometry and diode-array detection, Rapid Commun. Mass Spectrom., 16, 655, 2002. [Pg.503]

Taylor, M.R. and Teale, P., Gradient capillary electrochromatography of drug mixtures with UV and electrospray ionisation mass spectrometric detection, /. Chromatogr. A, 768, 89, 1997. [Pg.439]

Fast atom bombardment (FAB) Plasma desorption (PD) Liquid secondary-ion mass spectrometry (LSIMS) Thermospray (TSP)/plasmaspray (PSP) Electrohydrodynamic ionisation (EHI) Multiphoton ionisation (MPI) Atmospheric pressure chemical ionisation (APCI) Electrospray ionisation (ESI) Ion spray (ISP) Matrix-assisted laser desorption/ionisation (MALDI) Atmospheric pressure photoionisation (APPI) Triple quadrupole (QQQ) Four sector (EBEB) Hybrid (EBQQ) Hybrid (EB-ToF, Q-ToF) Tandem ToF-ToF Photomultiplier... [Pg.352]

Most recently, little use is being made of FAB-MS for polymer/additive deformulation, possibly as a result of a shift in interest towards electrospray ionisation and difficult quantitation. Practical applications of FAB-MS were reviewed [78,79,81],... [Pg.371]

ES ionisation can be pneumatically assisted by a nebulising gas a variant called ionspray (IS) [129]. ESI is conducted at near ambient temperature too high a temperature will cause the solvent to start evaporating before it reaches the tip of the capillary, causing decomposition of the analyte during ionisation and too low a temperature will allow excess solvent to accumulate in the sources. Table 6.20 indicates the electrospray ionisation efficiency for various solvents. [Pg.379]

Table 6.20 Electrospray ionisation efficiency Solution in water ...

The main characteristics of electrospray ionisation are given in Table 6.21. Electrospray ionisation is a suitable technique for producing accurate molecular mass information on a wide range of low-MW samples. ESI-MS is particularly appealing for polar, high-MW samples (more than ca. 1000 Da), where the multiply charged ions formed have m/z values within the range of the spectrometer. However, ESI presents some problems in the identification of unknowns ... [Pg.380]

The ionspray (ISP, or pneumatically assisted electrospray) LC-MS interface offers all the benefits of electrospray ionisation with the additional advantages of accommodating a wide liquid flow range (up to 1 rnl.rnin ) and improved ion current stability [536]. In most LC-MS applications, one aims at introducing the highest possible flow-rate to the interface. While early ESI interfaces show best performance at 5-l() iLrnin, ion-spray interfaces are optimised for flow-rates between 50 and 200 xLmin 1. A gradient capillary HPLC system (320 xm i.d., 3-5 xLmin 1) is ideally suited for direct coupling to an electrospray mass spectrometer [537]. In sample-limited cases, nano-ISP interfaces are applied which can efficiently be operated at sub-p,Lmin 1 flow-rates [538,539]. These flow-rates are directly compatible with micro- and capillary HPLC systems, and with other separation techniques (CE, CEC). [Pg.505]

Although electrospray ionisation has advantages for studies of ionic and very polar molecules, APCI is the preferred ionisation method for many other compounds - in that it provides better sensitivity and has advantages for quantitative studies. CE-APCI-MS studies were conducted on both QQQ and QITMS instruments [887]. [Pg.544]

ECNI Electron capture negative ionisation ESIMS Electrospray ionisation mass... [Pg.753]

Crawford, E., Dyson, P., Forest, O., Kwok, S. Mclndoe, J. S. Energy-dependent Electrospray Ionisation Mass Spectrometry of Carbonyl Clusters. [Pg.6]

Jahnke, A., Gandrass, J., Ruck, W. (2004). Simultaneous determination of alkylphenol ethoxylates and their biotransformation products by liquid chromatography/electrospray ionisation tandem mass spectrometry. J. Chromatogr. A 1035(1), 115-122. [Pg.444]

A range of MS ionisation techniques are available. Atmospheric pressure chemical ionisation (APCI) and electrospray ionisation (ESI) are becoming the methods of choice for the analysis of low molecular weight additives of mass/ charge (m/z) ratio <3,000. [Pg.570]

Figure 30 Overlay of standards sodium dodecyl sulfate (0-530 pig/kg) detecting m/z 265 with positive electrospray ionisation.

Giguere and Mayer [121] reported on the dissociation of gas-phase poly(vinyl acetate) (PVAc), see Figure 21, ionised by Li+ investigated by electrospray-ionisation (ESI) mass and collision induced dissociation (CID) mass spectrometry. [Pg.717]

Stintzing F C, Schieber A and Carle R (2002), Identification of betalains from yellow beet (Beta vulgaris L.) and cactus pear (Opuntia ficus-indica (L.) Mill.) by high-performance liquid chromatography - electrospray ionisation mass spectrometry , J Agric Food Chem, 50, 2302-2307. [Pg.328]

In the present chapter, we first provide some general information concerning the chemistry of waxes and lipids currently encountered in various items from our cultural heritage and we detail the main protocols based on direct mass spectrometry that have been developed so far. We then discuss the mass spectra obtained by EI-MS on a range of reference substances and materials sampled from museum and archaeological artefacts. We then focus on the recent possibilities supplied by electrospray ionisation for the elucidation of the structure of biomarkers of beeswax and animal fats. [Pg.98]

The type of proteinaceous binder was correctly identified in all model samples. In only one case (S10), the animal glue was additionally identified, although the restorer who prepared these model samples declared that the sample contained only egg binder. It is possible that this sample was contaminated during its preparation or during laboratory treatment. The results indicate that this method does not allow reliable identification of the presence of individual egg yolk and egg white most probably it is caused by the presence of a trace of egg white that is always present in the egg yolk preparations (and vice versa) and can be detected by the highly sensitive PMM method. The identification of individual types of animal glues will never be reliable by MALDI-TOF mass spectrometry because of their similar composition the application of ESI (electrospray ionisation)-MS/MS (Section 6.5) could possibly overcome this problem. Only the fish glue, whose peptide... [Pg.177]

Thompson, A., Prescott, M., Chelebi, N., Smith, J., Brown, T., and Schmidt, G. (2007) Electrospray ionisation-cleavable tandem nucleic acid mass tag-peptide nucleic acid conjugates Synthesis and applications to quantitative genomic analysis using electrospray ionisation-MS/MS. Nucleic Acids Res. 35(4), e28. [Pg.1121]

Vallejo F, Tomas-Barberan FA and Ferreres F. 2004. Characterisation of flavonols in broccoli (Brassica oleracea L. var. italica) by liquid chromatography-UV diode-array detection-electrospray ionisation mass spectrometry. J Chromatogr A 1054(1—2) 181—193. [Pg.87]

Amao MB, Cano A, Alcolea JF and Acosta M. 2001b. Identification of hydrolysable tannins in the reaction zone of Eucalyptus nitens wood by high performance liquid chromatography-electrospray ionisation mass spectrometry. Phytochem Anal 12(2) 120—127. [Pg.293]

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