Streptococcus pyogenes infection treatment

Complicated skin and skin structure infections (SSSIs) For the treatment of complicated SSSIs caused by S. aureus (methicillin-susceptible and -resistant strains). Streptococcus pyogenes, or Streptococcus agalactiae. It has not been studied in the treatment of diabetic foot and decubitus ulcers. 

In mice infections with pneumococci were influenced very satisfactorily by aristolochic acid I. Rats with wounds infected with Staphylococcus aureus were treated intraperitoneally or orally with aristolochic acid I compared to controls, the treated animals recovered much faster. Rabbits after intravenous application of aristolochic acid I showed an increased antibactericial action of serum (97). Mice infected with bacteria including Staphylococcus aureus, Diphococcus pneumoniae, and Streptococcus pyogenes could be protected by treatment with 50 xg/kg ip of aristolochic acid I (97). 

Tetracyclines no longer can be entirely relied on in the treatment of streptococcal infections up to 40% of Streptococcus pyogenes and 10% of Streptococcus pneumoniae are resistant. 

Clarithromycin is indicated for the treatment of mild to moderate upper and lower respiratory tract infections as well as skin infections caused by susceptible strains of Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, H. influenzae, Legionella pneumophila, and Mycoplasma pneumoniae. The usual dosage is 250 to 500 mg twice a day for 7 to 14 days. 

Varaldo PE, Debbia EA, Nicoletti G, Pavesio D, Ripa S, Schito GC, Tempera G. Nationwide survey in Italy of treatment of Streptococcus pyogenes pharyngitis in children influence of macrolide resistance on clinical and microbiological outcomes. Artemis-Italy Study Group. Clin Infect Dis 1999 29(4) 869-73. 

Picibanil (OK 432) is derived from Streptococcus pyogenes and has been used in the treatment of cancers, lymphangiomas, and viral infections. Low-grade fever, nausea and vomiting, and an inflammatory reaction at the injection site were commonly reported, whereas joint pain and mild liver dysfunction were seldom described. 

Kava has been used traditionally as an antibacterial in the treatment of urinary tract infections (Locher et al., 1995) however, no clinical trials have established that it is truly effective. Kava extracts were not able to inhibit growth of Candida, Pseudomonas, E. coli, Streptococcus pyogenes, or Staphylococcus aureus (Locher et al., 1995). 

Azithromycin, an azalide macrolide antibiotic (500 mg p.o. as a single dose on day 1, followed by 250 mg daily on days 2 to 5 total accumulation dose is 1.5 g), is indicated in the treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease caused by Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, or Streptococcus pneumoniae mild community-acquired pneumonia caused by H. influenzae or S. pneumoniae uncomplicated skin and skin-structure infections caused by Staphylococcus aureus, Streptococcus pyogenes, or S. agalactiae second-line therapy of pharyngitis or tonsillitis caused by S. pyogenes and in nongonococcal urethritis or cervicitis caused by Chlamydia trachomatis. 

Mupirocin is an antibiotic agent that inhibits bacterial protein synthesis. It is indicated in treatment of impetigo caused by Staphylococcus aureus and Streptococcus pyogenes (topical ointment) and treatment of secondarily infected traumatic skin lesions (up to 10 cm in length or 100 cm in area). 

Quinupristin/dalfopristin is a streptogramin. Quinupristin inhibits the late phase of protein synthesis dalfopristin inhibits the early phase of protein synthesis. It is indicated in the treatment of serious or life-threatening infections associated with VREF treatment of complicated skin and skin-structure infections caused by Staphylococcus aureus (methicillin-susceptible) or Streptococcus pyogenes. 

Clarithromycin has been compared with amoxicillin suspension in the treatment of children with lower respiratory tract infections. No significant differences were seen between the groups with respect to clinical cure rates and incidence and severity of adverse events, which generally were mild [35], Five days of treatment with clarithromycin suspension was superior to 10 days of penicillin suspension in eradicating Streptococcus pyogenes in children with streptococcal pharyngitis [36]. 

A drug combination of the streptogramins, quinupristin and dalfopristin was approved for IV use in the treatment of infections caused by vancomycin-resistant Enterococcus faecium bacteremia as well as skin/skin structure infections caused by MRSAand methicillin-sensitive Streptococcus pyogenes. Certain strains of E. faecium are resistant to essentially all... 

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