Suspensions clarithromycin

Clarithromycin has been compared with amoxicillin suspension in the treatment of children with lower respiratory tract infections. No significant differences were seen between the groups with respect to clinical cure rates and incidence and severity of adverse events, which generally were mild [35], Five days of treatment with clarithromycin suspension was superior to 10 days of penicillin suspension in eradicating Streptococcus pyogenes in children with streptococcal pharyngitis [36]. 

McCarty, J., Hedrick, J. A., and Gooch, W. M. (2000). Clarithromycin suspension vs. penicillin V suspension in children with streptococcal pharyngitis. Adv. Therapy 17, 14-26. 

Clarithromycin 15 mg/kg per day in 2 doses (adult 250 mg twice daily) Diarrhea, vomiting, rash, abnormal taste, abdominal pain SJ Many drug interactions (inhibits cytochrome P-450 3A4) suspension cannot be refrigerated and has metallic taste same microbiologic issues as azithromycin... 

Take clarithromycin tablets with 8 oz of water the tablets and oral suspension may be taken with or without food... 

BIAXIN (Abbott) Contraindications (clarithromycin tablets, extended-release tablets, suspension)... 

Oral 250 mg capsules powder for 100, 200 mg/5 mL oral suspension Clarithromycin (Biaxin)... 

Clarithromycin occurs as a white crystalline solid that is practically insoluble in water, sparingly. soluble in alcohol, and freely soluble in aeetone. It is provided as 250- and 500-mg oral tablets and as granules for the preparation of aqueous oral suspensions containing 25 or 50 mg/mL. 

Numerous studies have compared clarithromycin to loracarbef, amoxicillin/ clavulanate, amoxicillin suspension, and cefaclor in the treatment of acute otitis media in children with similar clinical outcomes and side effects [37-41]. In mild to moderate skin and skin structure infections, clarithromycin was not significantly better than erythromycin (96-88% eradication rate), with similar GI-related events [42-47]. 

Macklin, J. L., James, I., Kearsley, N. J., and Coles, S. J. (1993). A single-blind, randomised, comparative study of clarithromycin and amoxycillin suspensions in the treatment of children with lower respiratory tract infections. J. Chemother. 5, 174-180. 

Pukander, J. S., Jero, J. P., Kaprio, E. A., and Sorri, M. J. (1993). Clarithromycin vs. amoxicillin suspensions in the treatment of pediatric patients with acute otitis media. Pediatr. Infect. Dis. J. 12,S118-S12I. 

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