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Streptococcus faecalis factor

Because of the multiplicity of folic acid factors reported in whole blood (Ul), the microbiologic assay for folic acid in whole blood and serum was regarded as valueless (C2, L8, W9) results based on S. faecalis methods (C2, C3) did not contradict this view. Streptococcus faecalis is inferior to L. casei in its utilization of the PGA polyglutamates... [Pg.221]

G8. Girdwood, R. H., The occurrence of growth factors for Lactobacillus leich-mannii, Streptococcus faecalis and Leuconostoc citrovorum in the tissues of pernicious anaemia patients and controls. Biochem. J. 52, 58-63 (1952). [Pg.243]

Studies on growth factors required by certain microorganisms, for example Streptococcus faecalis and Lactobacillus casei, and of their relevance in animal nutrition, led to the isolation and characterization of folic acid, pteroylglutamic acid (104), the structure of which was determined in 1946. It is an essential vitamin for man and together with vitamin B12 it is involved in the development of blood cells. Deficiency causes macrocytic anaemia. Many microorganisms do not use exogenous folic acid, but synthesize their own, and some... [Pg.160]

The isolation of lipoic acid in 1951 followed an earlier discovery that the ciliate protozoan Tetrahymena geleii required an unknown factor for growth. In independent experiments acetic acid was observed to promote rapid growth of Lactobacillus casei, but it could be replaced by an unknown "acetate replacing factor." Another lactic acid bacterium Streptococcus faecalis was unable to oxidize pyruvate without addition of "pyruvate oxidation factor." By 1949, all three unknown substances were recognized as identical.291 2913 After working up the equivalent of 10 tons of water-soluble residue from liver, Lester Reed and his collaborators isolated 30 mg of a fat-soluble acidic material which was named lipoic acid (or 6-thioctic acid).292 294... [Pg.795]

Schleifer KH, Kilpper-Balz R (1984) Transfer of Streptococcus faecalis and Streptococcus faecium to the genus Enterococcus nom. rev. as Enterococcus faecalis comb. nov. and Enterococcus faecium comb. nov. Int J Syst Bacteriol 34 31-34 Schleifer KH, Kilpper-Balz R (1987) Molecular and chemotaxonomic approaches to the classification of streptococci, enterococci and lactococd a review. Syst Appl Microbiol 6 1-19 Semedo T, Santos MA, Lopes MFS, Marques JJF, Crespo MTB, Tenreiro R (2003) Virulence factors in food, chnical and reference enterococci a common trait in the genus Syst Appl Microbiol 26 13-22... [Pg.123]

Substances IA Ib> and Ic are peptidic sexual agglutination factors of Saccharo-myces cerevisiae [181]. Rhodotorucine A is a peptide produced by type A cells of Rhodospridium toruloides which induces mating tube formation in yeast of mating type a [182]. A bacterial sex pheromone, called cPDl, has been isolated from Streptococcus faecalis. Its structure is phe-leu-val-met-phe-leu-ser-gly [183]. Competence in Streptococcus pneumoniae is induced by a heptadecapeptide, H-Glu-Met-Arg-Leu-Ser-Lys-Phe-Phe-Arg-Asp-Phe-Ile-Leu-Glu-Arg-Lys-Lys-OH which is destroyed by a protease [184]. [Pg.25]

Nutritional studies with Lactobacillus casei and Streptococcus faecalis R resulted in the discovery of new growth factors given the names norite eluate factor and folic acid, respectively. Assay methods using these two organisms were employed in the isolation of folic acid and related compounds from natural extracts. However, a number of previously reported biological responses to natural extracts may now be attributed to the folic acid group. [Pg.92]

Lipoic Acid. The formation of acetyl CoA from pyruvate involves an additional cofactor, lipoic acid. This compound was studied independently as a growth factor for the protozoa Tetrahymena (protogen), a growth factor for Lactobacillus casei (acetate replacing factor) and a pyruvate oxidation factor for Streptococcus faecalis. - Pure synthetic compounds were made and called thioctic acid and lipoic acid. The officially accepted name for the structure given below is lipoic acid. Lipoic acid is... [Pg.73]

Pyridoxal Phosphate, Codecarboxylase. An independent approach to the nature of the amino acid decarboxylases was made by Gunsalus, Umbreit, and collaborators. They found that the production of tyrosine decarboxylase by Streptococcus faecalis depended on the vitamin, pyri-doxine. In the absence of pyridoxine the cells grew but had little decarboxylase. However, addition of the vitamin permitted deficient cells to decarboxylate tyrosine, and dried cells exhibited active enzyme in the presence of pyridoxal (a derivative of pyridoxine) and ATP, implying the formation of an active cofactor from these substances. Pyridoxal is a more active growth factor for a strain of Streptococcus faecalis than pyridoxine both synthetic pyridoxal and pyridoxamine exhibit 5000 to 9000 times the activity of the hydroxy compound. ... [Pg.279]

Somewhat later O Kane and Gunsalus observed that, when Streptococcus faecalis was grown in a synthetic medium, the harvested cells were unable to oxidize pyruvic acid unless supplemented with yeast extract or other natural materials. The activity of yeast extract could not be replaced by any of the known coenzymes or vitamins. The name pyruvate oxidation factor (POF) was therefore used to designate the biological activity of this factor. [Pg.394]

O Kane, D. J. and Gunsalus, I. C. (1948) Pyruvic acid metabolism. A factor required for oxidation by Streptococcus faecalis. J. Bacteriol. 56, 499-506. [Pg.133]


See other pages where Streptococcus faecalis factor is mentioned: [Pg.325]    [Pg.375]    [Pg.802]    [Pg.325]    [Pg.211]    [Pg.325]    [Pg.802]    [Pg.315]    [Pg.443]    [Pg.715]    [Pg.339]   
See also in sourсe #XX -- [ Pg.394 ]




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