Experiments on Acetic Acid

In the first place, Stadie, Zapp and Lukens failed to obtain any evidence for the production of acetic acid or any other steam-volatile acids in liver slices of depancreatized cats. These authors state further that no evidence could be found in the literature for the production of acetic acid in the livers of normal or diabetic animals except for the report of Cook and Harrison. They believe that the acetic acid, which 

Cook and Harrison reported, can be explained as originating from the oxidizing agents used in the course of the analyses. 

It is evident that even if acetic acid could be demonstrated as an intermediate in fat oxidation, the experimental data are quite preponderant in indicating that it would not be a D-glucose-former. 

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