Staphylococcus pyogenes, inhibition

PANI-g-chitosan (CS) has been screened for its antimicrobial activity against Staphylococcus epidermidis. Staphylococcus aureus. Staphylococcus pyogenes, Escherichia coli, Candida albicans, Candida tropicalis and Candida krusei. The results of the antimicrobial activity of PANI and PANI-g-CS were assessed based on the average diameter of zones of inhibition (ZOI). The results confirmed that PANI-g-CS has an enhanced antimicrobial activity compared with PANI. PANI and PANI-g-CS also show greater antifungal activity than antimicrobial activity [21]. 

Mupirocin (Bactroban) inhibits a specific enzyme responsible for tRNA synthesis in susceptible bacteria. This drug is used topically to treat skin infections caused by Staphylococcus aureus or Streptococcus pyogenes. Likewise, mupirocin can be administered by nasal spray to treat local colonization of S. aureus in the nasal mucosa. This idea may be especially helpful in preventing systemic infection in individuals such as health care workers who are exposed to an outbreak of resistant strains of S. aureus. Local/topical administration of this drug is well tolerated, although some irritation of the skin may occur during topical use, and cough and respiratory irritation can occur when mupirocin is administered by nasal spray. 

Biological activity of the macrolide derived from tylosin against Pasteurella multocida and P. haemolytica (in particular) in vitro and P. multicida (in particular) in vivo has been tested on chicks. Remarkable inhibition of these viruses is obtained. It is also found active against Staphylococcus aureus, Streptococcus pyogenes and pneumoniae, Haemophilus influenzae, Mycoplasma gallisepticum, synoviae, hyorhinis and hyopneumoniae 222... 

The aqueous/methanol fraction of the dichloromethane extract of Carthamus lanatus L. exhibited a high rate of antibacterial activity against Staphylococcus aureus and Escherichia coli [35], while crude dichloromethane extracts of the aerial parts and roots of Leontopodium alpinum Cass, exhibited significant growth inhibition of Bacillus subtilis, Escherichia coli. Pseudomonas aeruginosa. Staphylococcus aureus and Streptococcus pyogenes [36]. 

Kava has been used traditionally as an antibacterial in the treatment of urinary tract infections (Locher et al., 1995) however, no clinical trials have established that it is truly effective. Kava extracts were not able to inhibit growth of Candida, Pseudomonas, E. coli, Streptococcus pyogenes, or Staphylococcus aureus (Locher et al., 1995). 

Mupirocin is an antibiotic agent that inhibits bacterial protein synthesis. It is indicated in treatment of impetigo caused by Staphylococcus aureus and Streptococcus pyogenes (topical ointment) and treatment of secondarily infected traumatic skin lesions (up to 10 cm in length or 100 cm in area). 

Quinupristin/dalfopristin is a streptogramin. Quinupristin inhibits the late phase of protein synthesis dalfopristin inhibits the early phase of protein synthesis. It is indicated in the treatment of serious or life-threatening infections associated with VREF treatment of complicated skin and skin-structure infections caused by Staphylococcus aureus (methicillin-susceptible) or Streptococcus pyogenes. 

Many bacteria are much more sensitive than E. coli to crystal violet. Thus Streptococcus pyogenes is inhibited by a dilution of 1 in 320000 (though not by 1 in 640000) and Staphylococcus aureus is killed by 1 in 2000000. Although these differences may be partly due to differences in sites of loss, there are different values for different species and (in the hosts) for different tissues in the one species. This affords a basis for the selective action of cationic drugs. 

Fry, B. A. Basic triphenylmethane dyes and the inhibition of glutamine synthesis by Staphylococcus aureus (Micrococcus pyogenes var. aureus). J. Gen. Microbiol 1957, 16, 341-349. 

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