Spleen properties

Wilbanks GA, Streilein JW Macrophages capable of inducing anterior chamber-associated immune deviation demonstrate spleen-seeking migratory properties. Reg Immunol 1991 4 130-137. 

Initially, liposomes seemed to be optimal drug carrier systems, but further research in general showed disappointing results [97]. The clinical utility of what are now called conventional liposomes was limited by their rapid uptake by phagocytic cells of the immune system, predominantly in the liver and spleen, resulting in their largely uncontrollable properties upon administration in vivo. 

Astatine, regardless of its electronic state vide infra), appears to possess many physiobiochemical properties similar to those of its nearest homolog, iodine 34, 57, 60, 119, 176). However, astatine also exhibits a proclivity to accumulate in macrophage-laden tissue, such as lungs, liver, and spleen 37, 60, 119) this has been attributed to its amphoteric character. 

Hydrogen telluride is a highly toxic gas and a strong irritant to eyes, nose and upper respiratory tract. Toxic properties are similar to hydrogen selenide. Inhalation can cause damage to lungs, liver and spleen. Short exposure to a high concentration can be lethal. 

T raditionally, milk thistle fruits have been used for disorders of the liver, spleen, and gall bladder, such as jaundice and gall bladder colic. Milk thistle has also been used for nursing mothers for stimulating milk production, as a bitter tonic, for hemorrhoids, for dyspeptic complaints, and as a demulcent in catarrh and pleurisy. It is stated to possess hepatoprotective, antioxidant, and choleretic properties (128). Current interest is focused on the hepatoprotective activity of milk thistle and its use for the treatment of liver, spleen, and gall bladder disorders (129). Recently it has been shown that silibinin reduced prostate-specific antigen levels in prostate carcinoma cells lines, indicating a possible role of silibinin in human prostate cancer (130,131). 

Glucocorticoids (corticosteroids) were the first hormonal agents recognized as having lympholytic properties. Administration of any glucocorticoid reduces the size and lymphoid content of the lymph nodes and spleen, although it has no toxic effect on proliferating myeloid or erythroid stem cells in the bone marrow. 

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