Hepatoprotective activities

Handa SS, Sharma A. (1990) Hepatoprotective activity of andrographolide against galactosamine and paracetamol intoxication in rats. Indian J Med Res 92 284-292. 

Bishayee, A., A. Sarkar, and M. Ghaterjee. Hepatoprotective activity of carrot (Daucus carota L.) against carbon tetrachloride intoxication in mouse liver. J Ethnopharmacol 1995 47(2) 69-74. 

Yoshikawa, M. et al., Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica, Bioorg. Med. Chem. Lett., 13, 1045, 2003. 

Yoshikawa, M. et al.. Bioactive constituents of Chinese natural medicines. III. Absolute stereostructures of new dihydroflavonols, hovenitins I, II and III, isolated from Hoveniae Semen Sen Eructus, the seed and fruit of Hovenia dulcis Thumb. (Rhamnaceae) inhibitory effect on alcohol-induced muscular relaxation and hepatoprotective activity, Yakugaku Zasshi, 117, 108, 1997. 

T raditionally, milk thistle fruits have been used for disorders of the liver, spleen, and gall bladder, such as jaundice and gall bladder colic. Milk thistle has also been used for nursing mothers for stimulating milk production, as a bitter tonic, for hemorrhoids, for dyspeptic complaints, and as a demulcent in catarrh and pleurisy. It is stated to possess hepatoprotective, antioxidant, and choleretic properties (128). Current interest is focused on the hepatoprotective activity of milk thistle and its use for the treatment of liver, spleen, and gall bladder disorders (129). Recently it has been shown that silibinin reduced prostate-specific antigen levels in prostate carcinoma cells lines, indicating a possible role of silibinin in human prostate cancer (130,131). 

Cassia occidentalis L. C. torosa Cav. Wang Jiang Nan (Coffee senna, sicklepod) (seed, root) Anthraquinones, torosachrysone, n-methylmorpholine, apigenin, galactomannan, cassiollin, xanthorin, dianthronic heteroside, helminthosporin.4-33 496 Mild purgative, lower blood pressure, antioxidative, antiasthmatic, antitoxic, antimalarial, antibacterial, anthraquinones and hepatoprotective activities. 

Table 2. Hepatoprotective Activity of Some Oleanene Giucuronides and...

Some oleanolic acid-type saponins were known to exhibit similar hepatoprotective activity [4, 7, 32, 42, 43, 44-46]. We also reported the hepatoprotective activity of Palustroside in which has a glucosyl carboxy group at C-28 [47]. As a part of our continuing study, we examined the preventive effects of five oleanolic acid-type glucuronides (90-95), Fig. (8), isolated from Dumasia tnmcata (Table 3) [48]. 

Some structure-hepatoprotective relationships were obtained through our experiments. Figure (9) shows the structure-hepatoprotective relationships of the aglycone moiety. That is to say, the P-hydroxy group at C-21 would enhance hepatoprotective activity on the contrary, the hydroxy group at C-23, 24, 29 and 30 could reduce the activity. On the other hand, the free carboxylic acid group at C-28 may mediate cytotoxicity toward liver cells. 

Natural products with hepatoprotective activity against TNF-a-dependent liver injury... 

Curcumin (9) is an arylheptanoid isolated from turmeric, the rhizome of Curcuma longa L. Turmeric has been used as a remedy for inflammatory in Asia for centuries. There are a number of reports supporting an anti-inflammatory effect of curcumin. Its hepatoprotective activity against inflammatory liver injury was also demonstrated in a recent study [105], where pretreatment with curcumin (50 mg/kg, p.o.) significantly inhibited the elevation of serum transaminase activities after intoxication with D-GalN and LPS in mice. The hepatoprotective effect is presumably... 

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