Clinical utility

Table 2. a-Amino, Acyl, or Ureido Penicillins Under Investigation or Exhibiting Limited Clinical Utility... 

Because of the outbreak of antimony-resistant leishmania sis and the need to develop an oraky-adrninistered therapy, the use of many other compounds has been considered. Those that appear to have clinical utility ate aHoputinol (62), ketoconazole (63), and both systemicaHy and topically applied paromomycin (8) (see Antiparasitic agents, antimycotics). 

Intravenous and Oral Platelet Ub/fi3 Receptor Antagonists Potential Clinical Utilities... 

Umbricht A, Hoover DR, Tucker MJ, et al Opioid detoxification with buprenorphine, clonidine, or methadone in hospitalized heroin-dependent patients with HIV infection. Drug Alcohol Depend 69 263-272, 2003 Villagomez RE, Meyer TJ, Lin MM, et al Post-traumatic stress disorder among inner city methadone maintenance patients. Subst Abuse Treat 12 253—257, 1995 Mining E, Kosten TR, Kleber H Clinical utility of rapid clonidine-naltrexone detoxification for opioid abusers. Br J Addict 83 567-575, 1988 Washton AM, Pottash AC, Gold MS Naltrexone in addicted business executives and physicians. J Clin Psychiatry 45 39 1, 1984 Wesson DR Revival of medical maintenance in the treatment of heroin dependence (editorial). JAMA 259 3314-3315, 1988... 

Creatine phosphate is formed from ATP and creatine (Figure 49-16) at times when the muscle is relaxed and demands for ATP are not so great. The enzyme catalyzing the phosphorylation of creatine is creatine kinase (CK), a muscle-specific enzyme with clinical utility in the detection of acute or chronic diseases of muscle. 

Lutsep TIL, Albers GW, de Crespigny A, Kamat GN, Marks MP, Moseley ME. Clinical utility of diffusion-weighted magnetic resonance imaging in the assessment of ischemic stroke. Ann Neurol 1997 41 574-580. 

The cannabinoid field was reviewed in Progress in Medicinal Chemistry Volume 35. Since that time great advances have been made in our understanding of cannabinoid receptor pharmacology. Many novel ligands have been discovered and several are expected to have exciting clinical utility. Medicinal chemistry approaches to the modulation of cannabinoid receptors are extensively reviewed in Chapter 6. 

The RWMS is included to assess the PCP abuser when specific evidence regarding verbal and nonverbal memory functions are necessary for treatment and rehabilitation planning, or when other HRB and WAIS-R performances suggest impairment of discrete memory functions. Originally, age norms for this test were generally inadequate, but Russell (1975, 1984) has developed scoring techniques and criteria that improve the clinical utility of this test. 

Office-based serologic testing provides a quick assessment (within 15 minutes) of an exposure to HP, but patients can remain seropositive for up to 1 year after eradication, making the clinical utility of this test limited. Stool antigen assays can be useful for the initial diagnosis or to confirm HP eradication, and unlike the urea breath test, are less affected by concomitant medication use.9... 

Critique available prognostic variables for clinical utility. 

Researchers have developed a multitude of new markers, and it is considered that these new markers will have greater clinical utility than markers of the past. These research studies show that we can expect these markers to bring about a change in therapy of patients or quality of life. As these new markers become available for some of the most common forms of cancer, the clinical laboratories will play an important role in diagnosing and treating malignancies and standardizing marker tests to achieve comparable results that contribute to the patients medical care and quality of life. 

George, S. L. Statistical considerations and modeling of clinical utility of tumor markers. Hema-tol. Oncol. Clin. North Am. 8,457-468 (1994). 

Hayes, D. F., Bast, R Desch, C. E., et al. A tumor marker utility grading system (TMUGS) A framework to evaluate clinical utility of tumor markers. J. Natl. Cancer Inst. 818, 1456-1466... 

The potential clinical utility of the bDNA assay in AIDS patients was demonstrated by monitoring CMV DNA levels in the blood of a patient undergoing gan-cilovir therapy (Chemoff et al 1997), in semen specimens from patients being treated with the antiviral nucleotide analogue cidofovir (Lalezari et al 1995), and in cerebrospinal fluid from patients with CMV neurologic infections (Flood et ai, 1997). These studies demonstrate that bDNA can be used to measure CMV DNA in various clinical specimens. To date, no comparisons of bDNA with other strategies for detection of CMV DNA in clinical specimens have been published. 

Charache S, Barton FB, Moore RD, Terrin ML, Steinberg MH, Dover GJ, Ballas SK, McMahon RP, Castro O, Orringer EP. Hydroxyurea and sickle cell anemia. Clinical utility of a myelo-suppressive quot switching quot ... 

---