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Spermidine acetyltransferase

Keywords Aminotransferase Putrescine utilization pathway Spermidine acetyltransferase Transporter y-Aminobutyric acid y-Glutamyl intermediate y-Glutamylation... [Pg.47]

Polyamines like spermidine and spermine, which bind tightly to nucleic acids and are abundant in rapidly proliferating cells, are present in parasitic helminths in amounts comparable to those in vertebrate cells. As the enzymes necessary for their synthesis are lacking in adult parasitic flatworms, it is assumed that these compounds are obtained from the host (Bacchi and Yarlett, 1 995). In F. hepatica a polyamine N-acetyltransferase has been characterized, that is thought to play a major role in the polyamine metabolism of this parasite by inactivating excess amines (Aisien and Walter, 1993). [Pg.404]

Cells treated with 5-FU undergo cell cycle arrest or apoptosis by inhibition of DNA synthesis. When human oral squamous cell carcinomas (HSC-2, HSC-3, HSC-4) were treated with 5-FU, viable cell numbers declined dose-dependently (CC50 determined after 24 hours treatment 3.4,6.9 and 1.7 p,M, respectively). The intracellular putrescine concentration slightly declined (Table 2) [29]. The combination treatment of 5-FU with N(l),N(ll)-diethylnorspermine (DEN-SPM), which is an inducer of spermidine/spermine N(l)-acetyltransferase (SSAT) that depletes polyamine, has been reported to augment the cytotoxic activity of 5-FU, suggesting possible clinical application [30]. [Pg.164]

Wang Y, Devereux W, Stewart TM, Casero RA Jr. 2001. Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf2) in the transcriptional regulation of the spermidine/spermine iV -acetyltransferase (SSAT) gene. Biochem. J. 355 45 9... [Pg.259]

The phosphinic acid polyamine analogue 370 is reported to be an effective inhibitor of purified human spermidine/spermine-N I-acetyltransferase (SSAT) and is claimed to be only the second example of a functional, non-superinducing inhibitor of human SSAT. The long-chain phosphonate analogues 371 and 372 are reported to exhibit cytostatic activity in vitro " ... [Pg.146]

Saab, N.H., West, E.E., Bieszk, N.C., Pteuss, C.V., Mank, A.R., Casero, R.A. Jr, and Woster, PJ. (1993) Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-lV -acetyltransferase (SSAT) and as potential antitumor agents. J. Med. Chem. 36 2998-3004. [Pg.271]

Keywords Aldehyde Epigenetic Inflammation Reactive oxygen species Spermidine/spermine A -acetyltransferase Spermine oxidase... [Pg.61]

In mammalian cells, the catabolism of spermine to spermidine occurs via one of two distinct pathways. As a substrate for spermidine/spermine IV -acetyltransferase (SSAT), spermine can be converted to A -acetylspermine, which is subsequently oxidized by the FAD-dependent acetylpolyamine oxidase (APAO) to form spermidine. Conversely, spermine can be directly oxidized by spermine oxidase (SMOX) to form spermidine. Spermidine is then back-converted to putrescine through the two-step SSAT/APAO reaction that includes an Af-acetylspermidine intermediate (Fig. 5.1). [Pg.62]

Fig. 5.1 The mammalian polyamine catabolic pathway. Spermine (Spm) is back-converted to spermidine (Spd) by either spermine oxidase SMOX) or spermidine/spermine Af-acetyltransferase SSAT) followed by acetylpolyamine oxidase APAO). Spermidine is further back-converted to putrescine Put) through the same SSAT/APAO mechanism. Both oxidation reactions generate the reactive oxygen species ROS) precursor H2O2 and aldehydes as by-products. The resulting reduction in spermine and spermidine pools implies diminished antioxidant and antiinflammatory functions... Fig. 5.1 The mammalian polyamine catabolic pathway. Spermine (Spm) is back-converted to spermidine (Spd) by either spermine oxidase SMOX) or spermidine/spermine Af-acetyltransferase SSAT) followed by acetylpolyamine oxidase APAO). Spermidine is further back-converted to putrescine Put) through the same SSAT/APAO mechanism. Both oxidation reactions generate the reactive oxygen species ROS) precursor H2O2 and aldehydes as by-products. The resulting reduction in spermine and spermidine pools implies diminished antioxidant and antiinflammatory functions...
Babbar N.GernerEW, Casero RA Jr (2006a) Induction of spermidine/spermine N1 -acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J 394 317-324 Babbar N, Hacker A, Huang Y, Casero RA Jr (2006b) Tumor necrosis factor alpha induces spermidine/spermine N 1-acetyltransferase through nuclear factor kappaB in non-small cell lung cancer cells. J Biol Chem 281 24182-24192... [Pg.71]

Chopra S, Wallace HM (1998) Induction of spermidine/spermine Nl-acetyltransferase in human cancer cells in response to increased production of reactive oxygen species. Biochem Pharmacol 55 1119-1123... [Pg.72]

Fioii LM, Turecki G (2011) Epigenetic regulation of spermidine/spermine Nl-acetyltransferase (SATl) in suicide. J Psychiatr Res 45 1229-1235... [Pg.72]

Matsui I, Wiegand L, Pegg AE (1981) Properties of spermidine Af-acetyltransferase from livers of rats treated with carbon tetrachloride and its role in the conversion of spermidine into putres-cine. J Biol Chem 256 2454-2459... [Pg.73]

Wang Y, Xiao L, ThiagaUngam A, NeUdn BD, Casero RA Jr (1998) The identification of a cis-element and a trans-acting factor involved in the response to polyamines and polyamine analogues in the regulation of the human spermidine/spermine Nl-acetyltransferase gene transcription. J Biol... [Pg.74]

Zahedi K, Soleimani M (2011) Spennidine/spermine-N(l)-acetyltransferase in kidney ischemia reperfusion injury. Methods Mol Biol 720 379-394 Zahedi K, Lentsch AB, OkayaT, Barone S, Sakai N, Witte DP, ArendLJ, Alhonen L, JeU J, Janne J, Porter CW, Soleimani M (2009) Spermidine/spermine-Nl-acetyltransferase ablation protects against liver and kidney ischemia-reperfiision injury in mice. Am J Physiol Gastrointest Liver Physiol 296 899-909... [Pg.74]

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See also in sourсe #XX -- [ Pg.55 ]



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Spermidine/spermine acetyltransferase

Spermidine/spermine acetyltransferase SSAT)

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