Sodium salts of N-

To 50 cc of a carefully purified aqueous solution of the sodium salt of N(7-chloromercuri-)3-methoxy-propyl)-d-a-camphoramic acid containing 40 mg of mercury per cc is added 10 cc of a solution containing 1.14 g (1 mol equivalent) of sodium thioglycollate and the mixture is then evaporated to dryness at room temperature and reduced pressure in the presence of a desiccant. The product is an amorphous white powder which decomposes at 156° to 158°C (uncorr,), and which was found on analysis to have a mercury content of 33.0%, according to U.S. Patent 2,576,349. 

On silylation-amination of the disodium salts of inosine-5 -phosphate 238a or of guanosine-5 -phosphate 238 b with benzylamine, the phosphate moieties are also transiently protected during amination by silylation (cf also the silylation of uridine-5 -phosphate 224) to give, after transsilylation with methanol and addition of NaOH, the desired sodium salt of N -benzyladenosine-5 -phosphate 239a in 80% yield and the sodium salt of the 2-amino derivative 239 b in 78% yield [64] (Scheme 4.23). 

Dichloroacetamide has been prepared from ethyl dichloroace-tate with alcoholic ammonia1 or aqueous ammonium hydroxide,2 from ethyl dichloromalonate and alcoholic ammonia,3 by the action of ammonia on pentachloroacetone,4 chloral cyanohydrin,5 and hexachloro-i,3,5-cyclohexanetrione,6 from chloral ammonia and potassium cyanide,7 by the action of hydrogen chloride on dichloroacetonitrile,8 from the reaction of asparagine with the sodium salt of N-chloro- -toluenesulfonamide,9 and by the action of an alkali cyanide and ammonia on chloral hydrate.10... 

Reactions of this type have been widely used for the synthesis of 1,5-benzoxazepines by the reactions of o-aminophenols and their derivatives with a variety of functionalized three-carbon chains. Thus reaction with 3-bromo-l-chloropropane gives (360) and reaction with 3-chloropropionyl chloride gives the analogous 4-oxo derivative. Similarly a,/3-unsatur-ated Icetones give (361), /3-ketoesters give (362), l,3-oxazolid-5-ones give (363), and the reaction of the sodium salt of N-methanesulfonyl-o-aminophenol with epichlorohydrin gives... 

A solution of the sodium salt of N-methylaniline in HMPA can be used to cleave the methyl group from aryl methyl ethers 825 ArOMe + PhNMe — ArO + PhNMe2. This reagent also cleaves benzylic groups. In a similar reaction, methyl groups of aryl methyl ethers can be cleaved with lithium diphenylphosphide Ph2PLi.826 This reaction is specific for methyl ethers and can be carried out in the presence of ethyl ethers with high selectivity. 

In the early 1920 s, while attempting to obtain the sodium salt of n-glu-cose, with the cooperation of Alfons Kunz, he discovered a new process for the catalytic saponification of sugar acetates, using sodium methoxide, a method which has now become a standard procedure. The process was modified and somewhat improved later, with the assistance of Eugen Pacsu and Arpad Gerecs. 

To 50 cc of a carefully purified aqueous solution of the sodium salt of N(y-chloromercuri-p-methoxy-propyl)-d-a-camphoramic acid containing 40 mg of... 

At first we focused on the preparation of pentabenzyl rigidin, 15, which led to the development of a viable reaction path to the carbon skeleton of 6 (Scheme 2). The choice of benzyl protecting groups was largely a consequence of providing stable and easily identifiable intermediates. Thus, combination of 6-chloro-l,3-dibenzyluracil (9) with the sodium salt of N-benzylglycine afforded the substitution adduct 10 in... 

Phenanthridine is known to undergo direct amination readily with hydride extrusion (the Chichibabin reaction) and further examples have been reported.22 More interesting is the preparation of 6-aminophenanthridine in high yield by the action of the sodium salt of N,N-dimethylhydrazine on phenanthridine in benzene. The adduct (224) (R = Me) loses dimethylamine on heating leaving the sodium salt of the 6-amino compound (225).318... 

The effect of a surfactant on skin depends on the type of surfactant as described earlier. Wilhelm et al. demonstrated the irritation potential of anionic surfactants.21 They evaluated the effects of sodium salts of n-alkyl sulfates with variable carbon chain length on TEWL and found that a C12 analog gave a maximum response. They suggested that the mechanisms responsible for the hydration of SC are related to the irritation properties of the surfactants. Leveque et al. also suggested22 that the hyperhydration of SC is consecutive to the inflammation process. They demonstrated that the increase of TEWL was induced by SDS without removal of SC lipids. SDS might influence not only SC barrier function, but also the nucleated layer of epidermis and dermal system associated with inflammation.23 Recently, no correlation was found between the level of epidermal hyperplasia and TEWL increase on the SDS-irritated skin.23 Further work would be needed to determine the effects of surfactants on skin. 

The sodium salt of N-2-thiazolyl dithiocarbamic acid (141) is obtained by reaction in NaOH between 2-aminothiazole and CS2 (Scheme 93) (305). The product obtained in neutral medium is described as the... 

The 5-endo and 6-endo cyclizations of a,a>-alkynols leading to dihydrofurans and dihydropyrans have been achieved with molybdenum and tungsten catalysis [6]. Transition-metal vinylidene intermediates have been claimed to be involved in these cycloisomerizations [7]. Related cyclizations of bis-homo-propargyl alcohols were recently developed using ruthenium catalysis as shown in Eq. (3) [8]. In the presence of the sodium salt of N-hydroxysuccinimide 9,... 

Treatment of anhydrous lanthanide(III) bromides with the sodium salt of N,N-diethyldithiocarbamate (dtc) in absolute ethanol yielded Ln(dtc>3 for Ln = La-Lu-Pm. Reaction of Ln(dtc)3 with N, /V-diethy ldithiocarbamate and tetraethyl ammonium bromide in ethanol yielded [(C2Hs)4N][Ln(dtc)4]. All the tetrakis complexes are isostructural while two series of isostructural tris complexes exist, one for Ln = La-Nd and the other for Ln = Sm-Lu. The tris complexes are probably 6-coordinate, and the tetrakis complexes 8-coordinate [261,262]. 

The Barton decarboxylation involves the preparation of O-acyl thiohydroxamates A from acid chlorides and sodium salt of N-hydroxy-2-thiopyridine (2.44), which undergoes... 

SYNS CUPRAL DDC DEDC DEDK DIETHYLCARBAMODITHIOIC ACID, SODIUM SALT DIETHYLDITHIOCARBAMATE SODIUM DIETHYL-DITHIOCARBAMIC ACID SODIUM DIETHYD DITHIOCARBAMIC ACID, SODIUM SALT DIETHYL SODIUM DITHIOCARBAMATE DITHIOCARB DITHIOCARBAMATE NCI-C02835 SODIUM DEDT SODIUM NJ4-DIETHYLDITHIOCARBAMATE SODIUM SALT of N,N-DIETHYLDITHIOCARBAMIC ACID THIOCARB USAF EK-2596... 

N-(Phenyl-p-arsinic acid) - nitrosoglycineamide, AsO OH)2. CgH4.N(NO).CHa.CO.NH2. is obtained from the sodium. salt of N-(phenyI-jp-arsinic acid )-glyeineaniide by the action of sodium nitrite and hydrochloric acid. It crystallises in rosettes and sheaves of silky needles, becoming yellow at 180° C. and melting at 182° to 188° C. It is readily soluble in hot acetic add, and dissolves to an almost colourless solution in sulphuric acid, which solution gives a brownish-red Liebermann test. 

Oximes. The reaction of p-benzoquinone dioxime, HQN=< =NQH, with nitric oxide in basic methanol solution is reported (8) to produce 2O2N— —N202. The sodium salt of n-butylaldoxime, RCH = NONa,... 

Some compounds can act both as initiator and activator simultaneously. For example, sodium salts of N-2-disubstituted j3-oxoamides decompose at elevated temperatures in the presence of lactam to yield isocyanate (activator) and sodium lactam [119]... 

Very recently Saboury et al. (2007) reported the tyrosinase inhibitory potentials of four sodium salts of N-alkyl xanthates [43] (see Fig. 2). The xanthates... 

Sodium-2-ethyl hexanoate will precipitate the sodium salt of N-derivatized cephalosporin C from solvents (29,30). 

The sodium salt of N-benzylideneglycine reacts with acyl chlorides to yield lV-acyl-5-oxazolidinones (equation 181). Fluorinated 5-oxazolidinones are obtained by condensing a-amino acids with hexafluoroacetone (equation 182) (77MI41801). 

The sodium salt of N-methyldithiocarbamate is converted by oxidation into the compounds 4-methyl-5-methylimino-4-aza-l,2-dithiolane-3-thione (13) and... 

Another synthesis of isoquinolines in which two ring bonds are formed involves the reaction of benzyl halides (74) with the sodium salt of N-(tosylamino)acetaldehyde dimethyl acetal. Treatment of the intermediate (75) with hydrochloric acid results both in ring-closure and aromatization (Scheme 48). ... 

The formation of aminals via the Gabriel reaction can arise on changing the solvent from toluene to dimethylformamide, in the presence of sodium salts of N-heterocycles.31 In this unique example, 63 could be prepared in useful quantities in a more practical technique than with previous methods which required high heat and/or pressure conditions.32 - The required phthalimide derivatives 62 was also formed but in low yields. 

The electrolytic oxidation of the sodium salt of (+ )-N-ethoxycarbonyl-Al-norarmepavine (46) led to the dimeric mixtures (47) and (48). The latter mixture was converted into a mixture of dauricine analogues (49) via O-benzylation, reduction with lithium aluminium hydride, and hydrogenolytic debenzylation. This transformation represents the first preparation of an analogue of a natural bis-benzylisoquinoline by oxidation of a phenolic monomeric benzylisoquinoline. Detailed studies on the mass-spectral cleavage patterns of bisbenzylisoquinolines have appeared. 

Alternative sulphur reagents that may be used to cause epoxidation are the N -(p-tolylsulphonyl)sulphilimines (44 X = H) they are produced (by a phase-transfer-catalysed process) from the trihydrate of Chloramine-T (the sodium salt of N-chlorotoluene-p-sulphonamide) with a solution of PhSCH2R in CH2Cl2. The lithiated materials (44 X = Li, R = H) or (44 X = Li, R = Ph) react with PhCHO to give quantitative yields of styrene and stilbene respectively. 

In addition to dehydroxylation, a useful protocol for decarboxylation has been developed. The procedure was introduced by Barton, using thiohydroxamic esters 9, prepared from activated carboxylic acids (RCOX) and the sodium salt of N-hydroxypyridine-2-thione. Simple thermolysis or photolysis of the esters (homolysis of the N—O bond) results in the production of alkyl radicals R, which can attack the sulfur atom of the thiocarbonyl group to propagate the fragmentation (4.9). 

L. Morales, L. Franco, M.T. Casas, J. Puiggah, Poly(ester amide)/ clay nanocomposites prepared by in situ polymerization of the sodium salt of N-chloroacetyl-6-aminohexanoic acid, J. Polym. Sci. A Polym. Chem. 47 (2009) 3616-3629. 

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