Chloral cyanohydrin

C2HCI3O 75-87-6) see Chloral hydrate Teclothiazide chloral cyanohydrin (C3H2C1,N0 513-96-2) see Diloxanide chloral hydrate... 

Dichloroacetamide has been prepared from ethyl dichloroace-tate with alcoholic ammonia1 or aqueous ammonium hydroxide,2 from ethyl dichloromalonate and alcoholic ammonia,3 by the action of ammonia on pentachloroacetone,4 chloral cyanohydrin,5 and hexachloro-i,3,5-cyclohexanetrione,6 from chloral ammonia and potassium cyanide,7 by the action of hydrogen chloride on dichloroacetonitrile,8 from the reaction of asparagine with the sodium salt of N-chloro- -toluenesulfonamide,9 and by the action of an alkali cyanide and ammonia on chloral hydrate.10... 

Diloxanide Diloxanide, 2,2-dichloro-iV-(4-furoyloxyphenyl)-Af-methylacetamide (37.2.4), is made by acylating 2,2-dichloro-iV-(4-hydroxyphenyl)-iV-methylacetamide (37.2.3) with -2-furoyl chloride. The 2,2-dichloro-iV-(4-hydroxyphenyl)-iV-methylacetiamide (37.2.3) is made by iV-acylating 4-hydroxy-Af-methylaniline with either dichloroacetyl chloride, or by an extremely original method of using chloral cyanohydrin [41 3]. 

Chloral cyanohydrin (3,3,3-trichloro lactonitrile, chlorocy anohy drin, chloral hydrocyanide) [513-96-2] Crotononitrile (2-butenenitrile,... 

With acid catalysis, alcohols add to the carbonyl group of aldehydes to give hemiacetals [RCH(OH)OR ]. Further reaction with excess alcohol gives acetals [RCH(OR )2]- Ketones react similarly. These reactions are reversible that is, acetals can be readily hydrolyzed by aqueous acid to their alcohol and carbonyl components. Water adds similarly to the carbonyl group of certain aldehydes (for example, formaldehyde and chloral) to give hydrates. Hydrogen cyanide adds to carbonyl compounds as a carbon nucleophile to give cyanohydrins [R2C(OH)CN],... 

It should be mentioned that perfluoro- and perchlorocyclobutanones form stable a-halohydrins (10) in the same manner that chloral and a-ketoalde-hydes do. Cyclopropanones (11) give hydrates, hemiacetals, and cyanohydrins extremely readily. 

Ooi and Maruoka found that aluminum alkoxide (83) prepared from aluminum complex (82) and tertiary propargyl alcohol reacts with highly electrophilic aldehydes, such as chloral and pentafluorobenzaldehyde, to give alkynyl transfer products in good yield (Scheme 6.65) [84]. Bisphenol structure of ligands on aluminum center is the most important feature to obtain the alkynylated products, and thus, in reactions with (84) or (85) instead of (83) dramatical decrease in the yield of alkynyl product was observed. Same group also reported that cyanide transfer reaction with acetone cyanohydrin as a cyanide donor catalyzed by complex (82) [84]. 

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