Sodium salicylate tablets

Sodium Salicylate Tablets 500 mg Bromophenol Blue Each ml ofO.INHCl = 16.01 mgofC7H5Na03... 

Sodium salicylate tablets Solutions, pharmaceutical Spirits, pharmaceutical Suppositories Syrups, pharmaceutical Tablets, pharmaceutical Thyroid preparations... 

Attama AA, Adikwu MU, Esimone CO. Binary combination of detarium gum and vee-gum as a binder in sodium salicylate tablets. Bole Chim Farm 1999 138 199 202. Soyeux P, Delacourte A, Delie B, Lefevre P, Boniface B. Influence of optimization of operating parameters with a new binder in wet granulation. I use in powder form. Eur J Pharm Biopharm 1998 46 95-103. 

Aspirin is available as capsules, tablets, enteric-coated tablets (Ecotrin), timed-release tablets (ZORprin), buffered tablets Ascriptin, Bufferin), and as rectal suppositories. Sodium salicylate is available genericaUy. Other salicylates include choline salicylate (Arthropan), choline magnesium trisalicylate (Trilisate), and magnesium salicylate Momentum). 

Oral 500, 750 mg tablets 500 mg capsules Sodium salicylate (generic)... 

Other salicylates available for systemic use include salsalate (salicylsalicylic acid disalcid, others), which is hydrolyzed to salicylic acid during and after absorption, sodium thiosalicylate (injection REXOLATe), choline salicylate (oral liquid arthropan), and magnesium salicylate (tablets magan, momemtum, others). A combination of choline and magnesium salicylates (choline magnesium, trisahcylate, triusate, others) also is available. 

Magnesium salicylate has a low incidence of Gl side effects. Both sodium salicylate and magnesium salicylate should be used cautiously in individuals in whom excessive amounts of these electrolytes might be detrimental. The possibility of magnesium toxicity in individuals with renal insufficiency exists. It is available as tablets, but its safety in children under 12 years of age has not been fully determined. 

Marlow E, Shangraw R. Dissolution of sodium salicylate from tablet matrices prepared by wet granulation and direct compression. J Pharm Sci 1967 56 498-504. 

A new salicylate eledrode based on polymer membranes was used in a flow injection analysis system [66]. The electrode membrane contains 29.2-31.0% of PVC, 5.8-6.3% of tetraoctylammonium salicylate, 58.5-62.7% of o-nitrophenyloctylether and 6.5% of p-ferf-octylphenol. The tubular electrode was stored for approx. 6 months in a sodium salicylate solution. The electrode shows the slope of response curve close to theoretical — 56.0 0.6 mV decade in the range of 5 x 10" -10" mol L the response time is up to 5 s. The electrode can be used in a pH range of 6-9. The log K selectivity coefficients are 2-2.9 for acetates, 1.8-2.2 for chlorates, 0.7-1.0 for nitrates and 0.6-1.3 for acetosalicylates. The tubular salicylate electrode can be used for determination of acetylsalicylic add, after its previous analysis to salicylate, in multicomponent preparations and effervescent tablets (Anadin Extra, Aspirin, Dolviran, Alka-Seltzer). The results of potentiometric measurements are consistent with the method used in pharmacopoeia 100.7 to 103% of the compound was obtained, with standard deviation of RSD 0.6-1.8%. 

Tablets of Sodium Salicylate, B.P.C, Usually contain 5 grains.

Dissolve an amount of powdered tablets equivalent to 0 3 g of sodium salicylate as completely as possible, in 25 ml of water, add 2 ml of concentrated hydrochloric acid and extract with successive 20-ml quantities of ether until complete extraction is effected, washing each extract with the same 5 ml of water. Combine the extracts, evaporate the ether (observing the precautions given on p. 557), dissolve the residue in 3 ml of neutral 95 per cent ethanol, add 15 ml of water and titrate with 0 1 N sodium hydroxide to phenol red. 1 ml O lN 0 01601 g. 

Fig. 16 Effect of lubricant on dissolution of rate of salicylic acid contained in compressed tablets, x, 3% magnesium stearate , no lubricant 0> 3% sodium lauryl sulfate. (From Ref. 21.).

CRUSH AN ASPIRIN TABLET. MIX WITH Vi TEASPOON SODIUM BISULFATE. HEAT. DROP A FEW DROPS OF METHANOL [OR DENATURED ALCOHOL) ONTO HOT MIXTURE. YOU GET SMELL OF WINTERGREEN OIL— METHYL SALICYLATE. 

Test the solubility of your sample in toluene and in hot water and note the peculiar character of the aqueous solution when it is cooled and when it is then rubbed against the tube with a stirring rod. Note also that the substance dissolves in cold sodium bicarbonate solution and is precipitated by addition of an acid. Compare a tablet of commercial aspirin with your sample. Test the solubility of the tablet in water and in toluene and observe if it dissolves completely. Compare its behavior when heated in a melting point capillary with the behavior of your sample. If an impurity is found, it is probably some substance used as binder for the tablets. Is it organic or inorganic To interpret your results, consider the mechanism whereby salicylic acid is acetylated. 

Fig. 25 Differences observed in the deformation of substances during tableting. Potassium chloride at low (A) and high com-pressional forces (B), pellets prepared by spherical agglomeration in a tablet surface (C) and in the inner part of a broken tablet (D), surface of an acetyl salicylic acid (ASA) tablet containing 10% sodium carbox5methyl starch (E) and the same surface after moistening with a finger (F). (From Ref...

This. salt is the one of choice fur salicylate medication and usually is administered with stxiium bicarbonate to le.ssen gastric distress, or it is administered in enteric-coated tablets. The u.se of sodium bicarbonate is ill advised because it decreases the plasma levels of salicylate and increases the excretion of free salicylate in the urine. 

If the label indicates it is not the standard adult dosage form, the amount of drug in a tablet or capsule may be increased to 500 mg in the case of acetylsedi-cylic acid and sodium or magnesium salicylates or 670 mg in the Ccise of choline salicylate. 

Figure 9.14 shows how magnesium stearate retards the dissolution of salicylic acid from tablets whereas tablets prepared using sodium lauryl sulfate (a soluble hydrophilic wetting agent) as a lubricant had rapid dissolution. 

Dangprasirt P, Ritthidej GC (1997) Development of diclofenac sodium controlled release solid dispersion tablet using optimization strategy. Drug Dev Ind Pharm 23 843-848 Andreopoulos AG, Hatzi E, Doxastakis M (2001) Controlled release of salicylic acid from poly(DL-lactide). J Mater Sci Mater Med 12 233-239... 

In the preparation of many pharmaceuticals we know that some components in the formulation are not compatible. For instance, if we mix acetyl salicylic acid with sodium bicarbonate in solution, there is an immediate reaction and a vigorous release of carbon dioxide. Nevertheless, it might be of interest to freeze-dry them together in order to have instant sparkling aspirin, but this is not possible and the only way around this is to compact the products together in the dry state. The resulting tablet is not very stable and it takes a relatively long time to get back into solution. 

Tablets of Aspirin and Phenacetin, B.P.C. Contain 3 grains of aspirin and 2 grains of phenacetin. These tablets are assayed by dissolv-ing in dilute sodium hydroxide solution, extracting the phenacetin with chloroform, then heating the aqueous residue to hydrolyse the aspirin and determining the salicylic acid, either by extraction with ether after acidification as given under Compound Tablets of Aspirin, or by bromination as given under Salicylic Acid. The sodium citrate hydrolysis method given above for the determination of aspirin can also be applied directly to this preparation.

The CWS procured more than 10,000 gas casualty treatment kits. The contents of the 1945 kit, representing the best efforts of wartime medical research in the treatment of chemical agent injuries, and containing in lesser or greater quantities the material also found in the first-aid kit and veterinary set, included BAL ointment (for removal of arsenicals from the skin), petrolatum and amyl salicylate (for removal of mustard from the skin), sodium sulamyd (to prevent blister gas eye infection), copper sulfate solution (to remove WP particles from the skin), copper sulfate powder (to replenish solution), sulfadiazine tablets or penicillin (to prevent secondary infection), a floating white soap (for decontamination), BAL eye ointment (for any liquid blister gas contamination of eyes), eye and... 

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