Matrix tablet

This case study illustrates the SP method development of an assay method for a controlled-release analgesic tablet with a single API. Certain considerations were taken into account. First, the analyte within the tablet matrice core had to be extracted quantitatively. Second, the analyte was diluted into a final solution that was compatible with the HPLC mobile phase. Third, short SP time was required (i.e., 30 min) to maximize productivity of the work scheme for processing a large number of samples. 

Polyelectrolyte complexes have also been studied as tablet matrices for controlled release applications. For example, the interpolymer complexes of chitosan with pectin and acacia were investigated as tablet matrices for release of chlorpromazine HCL [353]. The complex formed in situ by mixing chitosan with either pectin or acacia displayed the most efficient sustained release (compared to either pectin, acacia or a preformed complex). The results were attributed to the swelling and gel-forming capacity of the freshly formed complex in contrast to the preformed version. 

Chilamkurti, R. N., Rhodes, C. T., and Schwartz, J. B. (1982), Some studies on compression properties of tablet matrices using a computerized instrumented press, Drug Dev. Ind. Pharm., 8, 63-86. 

Hariharan M, Wheatley TA, Price JC. Controlled-release tablet matrices from carrageenans compression and dissolution studies. Pharm Dev Technol 1997 2(4) 383-393. 

Citric acid (as either the monohydrate or anhydrous material) is widely used in pharmaceutical formulations and food products, primarily to adjust the pH of solutions. It has also been used experimentally to adjust the pH of tablet matrices in enteric-coated formulations for colon-specific drug delivery. Citric acid monohydrate is used in the preparation of effervescent granules, while anhydrous citric acid is widely used in the preparation of effervescent tablets.Citric acid has also been... 

Khan G, Meidan VM. Drug release kinetics from tablet matrices based upon ethylcellulose ether-derivatives A comparison between different formulations. Drug Dev Ind Pharm 2007 33(6) 627-39. 

For analysis of more complicated tablet matrices, it is unlikely that training sets of 14 or fewer samples would suffice in the development of robust models for quantitation or qualitative discrimination. Considering a typical tablet with, say,... 

S. Lee, H. G. DeKay, and G. S. Banker, Effect of water vapor pressure on moisture sorption and the stability of aspirin and ascorbic acid in tablet matrices,/. Pharm. Sci. 54, 1153-1 158 (1965). 

TK Chukwu, A Chukwu. OK Udcala, Hydrophilic polymers as drug release modulators from non-disintegrating tablet matrices. Acta. Pharmaceutica. 42 181-188. 1992. 

Karaya gum is a hydrophilic polysaccharide obtained from the Khaya grandifiola tree. Khaya gum is used as a binding agent in tablets and for controlled release. Khaya gum provides a controlled release in paracetamol tablets for 5h. A combination of khaya gum and hy-droxypropyl methyl cellulose showed a zero-order release kinetics. Therefore, tablet matrices containing khaya gum can be used for sustain release (31,32). 

Marlow E, Shangraw R. Dissolution of sodium salicylate from tablet matrices prepared by wet granulation and direct compression. J Pharm Sci 1967 56 498-504. 

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