Choline magnesium trisalicylate 42

Aspirin, sodium salicylate, choline magnesium trisalicylate, salsalate, diflunisal, salicylsalicylic acid, sulfasalazine, olsalazine... 

In medical practice, other salicylic acid derivatives are used in the form of salts. Magnesium salicylate and sodium salicylate are less effective than respective doses of aspirin however, they are easier on patients that are sensitive to aspirin. Choline magnesium trisalicylate represents a mixture of choline salicylate and magnesium salicylate, which has the same effect as aspirin however, it is easier on patients in which gastrointestinal effects are observed upon taking aspirin. 

Tablets 500 mg salicylate (as 293 mg choline salicylate and 362 mg Mg salicylate), 750 mg salicylate (as 440 mg choline salicylate and 544 mg Mg salicylate), 1,000 mg salicylate (as 587 mg choline salicylate, 725 mg Mg salicylate) (Rx) Choline Magnesium Trisalicylate (Sidmak), Tricosal (Invamed)...

Aspirin Diflunisal Choline salicylate Choline-magnesium trisalicylate Sodium salicylate Salsalate... 

Aspirin is available as capsules, tablets, enteric-coated tablets (Ecotrin), timed-release tablets (ZORprin), buffered tablets Ascriptin, Bufferin), and as rectal suppositories. Sodium salicylate is available genericaUy. Other salicylates include choline salicylate (Arthropan), choline magnesium trisalicylate (Trilisate), and magnesium salicylate Momentum). 

Contraindications Allergy to tartrazine dye, bleeding disorders, GI bleeding or ulceration, history of hypersensitivity to choline magnesium trisalicylate, aspirin, or NSAIDs. 

Aspirin 1.3 to 3.6 g daily more than halved the serum levels of ibuprofen 800 mg to 2.4 g daily, without affecting salicylate levels. There was little additional clinical benefit from the combination. Similarly, aspirin reduced the AUC of flurbiprofen by about two-thirds, but without any clear changes in clinical effectiveness. The pharmacokinetics of the aspirin were unchanged by flurbiprofen. Aspirin 3.9 g daily also virtually halved the AUC of fenoprofen 2.4 g daily,and reduced the AUC of ke-toprofen 200 mg daily by about one-third. The AUC of naproxen was only minimally reduced (by 10 to 15%). Choline magnesium trisalicylate increased the clearance of naproxen by 56% and decreased its serum levels by 26% in one study. ... 

Sucralfate appears not to have a clinically important effect on the pharmacokinetics of aspirin, choline-magnesium trisalicylate, diclofenac, ibuprofen, indometacin, ketoprofen, naproxen or pirox-icam. 

About 10% of asthmatics are hypersensitive to aspirin, and in some individuals life-threatening bronchoconstriction can occur. This is not a drug-drug interaction but an adverse response of asthmatic patients to aspirin, whether taking an anti-asthmatic drug or not. The reasons are not fully understood. Those known to be sensitive to aspirin may also possibly react to other NSAIDs, in particular the acetylated salicylates, the indole and indene acetic acids, and the propionic acid derivatives (see Table 6.1 , (p.l34)). The fenamates, oxicams, pyrazolones and pyrazolidinediones are better tolerated. The nonacetylated salicylates (sodium salicylate, salicylamide, choline magnesium trisalicylate) are normally well tolerated. Aspirin-sensitive individuals are also less likely to react to nimesulide. ... 

Salicylic acid derivatives Acetylsalicylic acid Sodium salicylate Choline salicylate Choline magnesium trisalicylate... 

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