4-ferf-octylphenol

Environmental chemicals such as p-nonylphenol (NP), 4-ferf.-octylphenol (OP), 4-ferf.-pentylphenol (TPP), bisphenol-A (BPA), tetrabromobisphenol-A (TBBA), butylbenzylphthalate (BBP), di- -butylphthalate (DBP), butylated hydroxyanisole (BHA), p-chloro-ra-cresol, p-chloro-o-cresol, ds-nonachlor, frans-nonachlor, and the herbicide alachlor [2-chloro-iV-(2,6-diethylphenyl)-N-(methoxymethyl) acetamide] have been discovered to be weakly estrogenic [128,129,137,138]. 

Sales et al. (2001) developed a potentiometric sensor for the determination of tartaric acid. Tartrate-sensitive electrodes were constructed, comprising poly(vinyl chloride) membranes. Various membrane compositions were evaluated and the one combining an ionic sensor (bis(triphenylphosphoranylidene)ammonium chloride), 4-ferf-octylphenol, and o-nitrophenyl octyl ether was selected. The analytical characteristics of this electrode were evaluated using a single-line flow injection manifold. The accuracy of the developed method was demonstrated for the determination of tartaric acid in red and white wine samples. 

The related compound, 4-ferf-octylphenol (4-(l,l,3,3-tetetramethylbutyl)phenol), has recently been named as a substance of very high concern (SVHC) in the EU as an endocrine disrupter. 

Contrary to monoalkyl derivatives, the presence of two alkyl groups in positions 2 and 5 (Type Ic) and 2 and 6 (Type lib) lowered the efficiency of 4-alkoxyphenols. Similar influences of substitution can be shown when comparing the activities of 4-acetoxy-2-terf-octylphenol and 4-acetoxy-2,5-di-ferf-octylphenol (Table IV). The change in the nature of alkyl groups influences the activity of Type lib antioxidants in a manner similar to that of 2,4,6-trialkylphenols the antioxidative efficiency decreased in the latter group, introducing a bulkier alkyl group into position 4, when the substituents in the positions 2 and 6 remained the same (the values of relative activities are referred to hydroquinone). 

A new salicylate eledrode based on polymer membranes was used in a flow injection analysis system [66]. The electrode membrane contains 29.2-31.0% of PVC, 5.8-6.3% of tetraoctylammonium salicylate, 58.5-62.7% of o-nitrophenyloctylether and 6.5% of p-ferf-octylphenol. The tubular electrode was stored for approx. 6 months in a sodium salicylate solution. The electrode shows the slope of response curve close to theoretical — 56.0 0.6 mV decade in the range of 5 x 10" -10" mol L the response time is up to 5 s. The electrode can be used in a pH range of 6-9. The log K selectivity coefficients are 2-2.9 for acetates, 1.8-2.2 for chlorates, 0.7-1.0 for nitrates and 0.6-1.3 for acetosalicylates. The tubular salicylate electrode can be used for determination of acetylsalicylic add, after its previous analysis to salicylate, in multicomponent preparations and effervescent tablets (Anadin Extra, Aspirin, Dolviran, Alka-Seltzer). The results of potentiometric measurements are consistent with the method used in pharmacopoeia 100.7 to 103% of the compound was obtained, with standard deviation of RSD 0.6-1.8%. 

Industrial Chemicals/Byproducts 4-Nonylphenol Octylphenol Bisphenol-A 4-ferf-pentylphenol Benzo (a) pyrene Phenanthrene Polychlorinated biphenyls Dioxins... 

The most used phenol-formaldehyde resins are based on phenol or p-ferf-butylphenol and formaldehyde. However, other phenols can be used, such as resorcinol, cresols, guayachol (2-methoxy phenol), p-phenylphenol, xylenols, amylphenol, octylphenol, nonylphenol and bisphenol A. In some resins, a mixture of phenols is used. Aldehydes other than formaldehyde are occasionally used, for example, furfural. 

Studies conducted in Japan and the U.S. have detected APs in indoor air, household dust, and household items. Both 4-NP and 4-ferf-OP were detected in indoor air with median levels at 47.5 and 3.2 ng per cubic meter (m ), respectively, in households of Tokyo, Japan (Saito et al. 2004). Additional monitoring identified PVC-based materials used in household floor and wall coverings as a possible source of APs in indoor air. Studies by Rudel and colleagues indicate that NP as well as certain nonylphenol-ethoxylates (NPEs) and octylphenol-ethoxylates... 

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