Sodium acetate nitrate

Diazoaminobenzene has been prepared by the action of sodium nitrite on aniline sulfate by the action of sodium nitrite on aniline hydrochloride by the action of sodium nitrite and sodium acetate on aniline hydrochloride by the action of ammonium nitrate and hydrogen sulfide on aniline hydrochloride in the presence of iron and by the action of amyl nitrite on aniline. ... 

The immediate outcome of the Hantzsch synthesis is the dihydropyridine which requires a subsequent oxidation step to generate the pyridine core. Classically, this has been accomplished with nitric acid. Alternative reagents include oxygen, sodium nitrite, ferric nitrate/cupric nitrate, bromine/sodium acetate, chromium trioxide, sulfur, potassium permanganate, chloranil, DDQ, Pd/C and DBU. More recently, ceric ammonium nitrate (CAN) has been found to be an efficient reagent to carry out this transformation. When 100 was treated with 2 equivalents of CAN in aqueous acetone, the reaction to 101 was complete in 10 minutes at room temperature and in excellent yield. 

N,N -dimethyloxaldiamide is reacted with PCI5 to give 4-chloro-1-methyl imidazole. This is nitrated with HNO3 to give 5-nitro-1-methyl-4-chloroimidazole. Then, a mixture of 4.6 grams of anhydrous 6-mercaptopurine, 5 grams of 1-methyl-4-chloro-5-nitroimidazole and 2.5 grams of anhydrous sodium acetate in 100 ml of dry dimethyl sulfoxide was heated at 100°C for 7 hours. 

Discussion. Arsenates in solution are precipitated as silver arsenate, Ag3 As04, by the addition of neutral silver nitrate solution the solution must be neutral, or if slightly acid, an excess of sodium acetate must be present to reduce the acidity if strongly acid, most of the acid should be neutralised by aqueous sodium hydroxide. The silver arsenate is dissolved in dilute nitric acid, and the silver titrated with standard thiocyanate solution. The silver arsenate has nearly six times the weight of the arsenic, hence quite small amounts of arsenic may be determined by this procedure. 

Determination of vanadium as silver vanadate Discussion. Vanadates are precipitated by excess of silver nitrate solution in the presence of sodium acetate after boiling, the precipitate consists of silver orthovanadate. The following reactions occur with a solution of a metavanadate ... 

Reagents. In view of the sensitivity of the method, the reagents employed for preparing the ground solutions must be very pure, and the water used should be re-distilled in an all-glass, or better, an all-silica apparatus the traces of organic material sometimes encountered in demineralised water (Section 3.17) make such water unsuitable for this technique unless it is distilled. The common supporting electrolytes include potassium chloride, sodium acetate-acetic acid buffer solutions, ammonia-ammonium chloride buffer solutions, hydrochloric acid and potassium nitrate. 

The preparation of silver phthalocyanine (PcAg) is carried out by metal insertion into metal-free phthalocyanine from silver(I) nitrate. The reaction is performed in dimethylformamide291 or in a mixture of 1,2-dichloroethane, sodium acetate and acetic acid.231... 

The silver acetate can be replaced by a mixture of sodium acetate and silver nitrate. 

Nitrobenzoyl peroxide,2 as well as w-nitrobenzoyl peroxide2 and anisoyl peroxide,3 have been prepared in about 50 per cent yields from the acid chlorides and an acetone solution of hydrogen peroxide, in the presence of a basic substance such as pyridine, sodium acetate, or sodium hydroxide. w-Nitrobenzoyl peroxide has also been prepared by nitration of benzoyl peroxide with cold... 

The primary synthetic route proceeds via oxidative dimerization of 2-aminoan-thraquinone in the presence of an alkali hydroxide. 2-aminoanthraquinone, for instance, is fused with potassium hydroxide/sodium hydroxide at 220 to 225°C in the presence of sodium nitrate as an oxidant. New techniques involve air oxidation of 1-aminoanthraquinone at 210 to 220°C in a potassium phenolate/sodium acetate melt or in the presence of small amounts of dimethylsulfoxide. A certain amount of water which is formed during the reaction may be removed by distillation in order to improve both efficiency and yield. 

A weight of compound, containing about 0-05 g. of fluorine, was dissolved in 10 ml. of dry alcohol and metallic sodium (about 0 5 g., i.e. at least 5 equivalents) was added. After the sodium had dissolved, the mixture was gently heated under reflux for 5 min.,8 and then washed out with about 100 ml. of water into a beaker, made acid to bromophenol blue with dilute nitric acid and then just alkaline with 10 per cent sodium hydroxide solution. Three ml. of 10 per cent sodium chloride solution were added and the solution was diluted to 250 ml. One ml. of concentrated hydrochloric acid was added, and the solution heated on a water-bath to about 80°. Then 5-0 g. of finely powdered A.R. lead nitrate were added with stirring (still at 80°). As soon as all the lead nitrate had dissolved, 5-0 g. of crystalline sodium acetate were added, with vigorous stirring. The product was then heated on the water-bath for 15 min. and cooled in ice, and the precipitate was filtered off on a Swedish filter paper. It was washed once with water, four times with saturated PbClF solution... 

As esters the alkyl halides are hydrolysed by alkalis to alcohols and salts of halogen acids. They are converted by nascent hydrogen into hydrocarbons, by ammonia into amines, by alkoxides into ethers, by alkali hydrogen sulphides into mercaptans, by potassium cyanide into nitriles, and by sodium acetate into acetic esters. (Formulate these reactions.) The alkyl halides are practically insoluble in water but are, on the other hand, miscible with organic solvents. As a consequence of the great affinity of iodine for silver, the alkyl iodides are almost instantaneously decomposed by aqueous-alcoholic silver nitrate solution, and so yield silver iodide and alcohol. The important method of Ziesel for the quantitative determination of alkyl groups combined in the form of ethers, depends on this property (cf. p. 80). 

Lithium carbonate, 0533 Lithium dithionite, 4687 Magnesium carbonate hydroxide, 0534 Magnesium nitrate, 4693 Magnesium nitrite, 4692 Magnesium sulfate, 4696 Potassium carbonate, 0531 Potassium nitrite, 4649 Silver hyponitrite, 0031 Sodium acetate, 0779 Sodium carbonate, 0552 Sodium disulfite, 4808 Sodium dithionite, 4807 Sodium hydrogen carbonate, 0390 Sodium hydrogen sulfate, 4446 Sodium metasilicate, 4805 Sodium nitrite, 4720 Sodium sulfate, 4806 Sodium tetraborate, 0185 Sodium thiosulfate, 4804... 

Von Runge and Triebs used a solution of dinitrogen pentoxide in chloroform for the N-nitration of both amides and imides. Solutions of dinitrogen pentoxide in chlorinated solvents are not neutral nitrating agents when amides and imides are nitrated - the presence of acidic N-H protons in these substrates leads to the formation of nitric acid. Sodium fluoride acts like a base towards nitric acid and so its addition to these reactions can increase product yield. Sodium acetate has been used for the same purpose during the nitration of n-butyl-V, V -dimethylurea. The effectiveness of dinitrogen pentoxide for the V-nitration of ureas is further illustrated by its use in the conversion of 2-imidazolidinone to N, V -dinitro-2-imidazolidinone in 90 % yield. In the presence of sodium fluoride the yield for this reaction exceeds 90 %. 

The nitrolysis of hexamine at low temperature has led to the synthesis of a number of cyclic nitramines. The reaction of hexamine dinitrate (241) with 88 % nitric acid at -40 °C, followed by quenching the reaction mixture onto crushed ice, leads to the precipitation of 3,5-dinitro-3,5-diazapiperidinium nitrate (242) (PCX) in good yield PCX is an explosive equal in power to RDX but is slightly more sensitive to impact. The reaction of PCX (242) with sodium acetate in acetic anhydride yields l-acetyl-3,5-dinitro-l,3,5-triazacyclohexane (82) (TAX), which on further treatment with dilute alkali in ethanol yields the bicycle (243). ... 

Axenrod and co-workers reported a synthesis of TNAZ (18) starting from 3-amino-l,2-propanediol (28). Treatment of (28) with two equivalents of p-toluenesulfonyl chloride in the presence of pyridine yields the ditosylate (29), which on further protection as a TBS derivative, followed by treatment with lithium hydride in THF, induces ring closure to the azetidine (31) in excellent yield. Removal of the TBS protecting group from (31) with acetic acid at elevated temperature is followed by oxidation of the alcohol (32) to the ketone (33). Treatment of the ketone (33) with hydroxylamine hydrochloride in aqueous sodium acetate yields the oxime (34). The synthesis of TNAZ (18) is completed on treatment of the oxime (34) with pure nitric acid in methylene chloride, a reaction leading to oxidation-nitration of the oxime group to em-dinitro functionality and nitrolysis of the A-tosyl bond. This synthesis provides TNAZ in yields of 17-21 % over the seven steps. 

Another transient aminoxyl radical has been generated , and employed in H-abstraction reactivity determinations" . Precursor 1-hydroxybenzotriazole (HBT, Table 2) has been oxidized by cyclic voltammetry (CV) to the corresponding >N—O species, dubbed BTNO (Scheme 9). A redox potential comparable to that of the HPI —PINO oxidation, i.e. E° 1.08 V/NHE, has been obtained in 0.01 M sodium acetate buffered solution at pH 4.7, containing 4% MeCN". Oxidation of HBT by either Pb(OAc)4 in AcOH, or cerium(IV) ammonium nitrate (CAN E° 1.35 V/NHE) in MeCN, has been monitored by spectrophotometry , providing a broad UV-Vis absorption band with A-max at 474 nm and e = 1840 M cm. As in the case of PINO from HPI, the absorption spectrum of aminoxyl radical BTNO is not stable, but decays faster (half-life of 110 s at [HBT] = 0.5 mM) than that of PINO . An EPR spectrum consistent with the structure of BTNO was obtained from equimolar amounts of CAN and HBT in MeCN solution . Finally, laser flash photolysis (LFP) of an Ar-saturated MeCN solution of dicumyl peroxide and HBT at 355 nm gave rise to a species whose absorption spectrum, recorded 1.4 ms after the laser pulse, had the same absorption maximum (ca 474 nm) of the spectrum recorded by conventional spectrophotometry (Scheme 9)59- 54... 

Basic lead carbonate also is precipitated by dissolving lead monoxide in lead(II) acetate solution, and treating the solution with carbon dioxide. It also is produced by electrolysis of sodium nitrate or sodium acetate using lead anode and then precipitating out the product by adding sodium carbonate. 

A chromatographic mobile phase consisting of acetonitrile/0.1 M sodium acetate buffer pH 4.0 (70 30) is prepared. Separate stock solutions in 250 ml of chromatographic mobile phase containing miconazole nitrate (200 20 mg) and econazole nitrate (200 20 mg) (internal standard) are prepared. 25 ml of econazole nitrate stock solution is transferred to five 100 ml volumetric flasks and varying amounts of miconazole stock solution 15, 20, 25, 30 and 35 ml are added to the five flasks. The flasks containing the calibration series are diluted to volume with mobile phase. A sample of cream containing 20 mg miconazole nitrate is shaken with 25 ml... 

For complete neutralization to take place, the proper amounts of acid and base must be present. The salt formed in the above reaction is NaCl. If the water were evaporated after completing the reaction, we would be left with common table salt. Sodium chloride is just one of hundreds of salts that form during neutralization reactions. While we commonly think of salt, NaCl, as a seasoning for food, in chemistry a salt is any ionic compound containing a metal cation and a nonmetal anion (excluding hydroxide and oxygen). Some examples of salts that result from neutralization reactions include potassium chloride (KCl), calcium fluoride (CaF ), ammonium nitrate (NH NOj), and sodium acetate (NaC2H302). 

Sulfonation (66JOC565) or nitration (74JOC1157) of the acridizinium (benzo[Z ]quin-olizinium) ion (3) occurs at position 10 (Scheme 31). When acridizinium bromide is dissolved in liquid bromine and allowed to stand for 15 h the perbromide salt of 7,8,9,10-tetrabromo-7,8,9,10-tetrahydroacridizinium ion is formed and this is easily converted to the simple bromide by the action of acetone. If the tetrabromo salt is refluxed in xylene, it is reconverted to acridizinium bromide (3) in good yield. Treatment of the tetrabromide with sodium acetate gives 10-bromoacridinium bromide (Scheme 32). 

Pour a hydroiodic acid solution into three test tubes. Add solutions of sodium acetate and lead acetate to the first tube, of silver nitrate (one or two drops) to the second one, and put a small piece of marble into the third tube. Write the equations of the reactions for all the processes occurring in the given experiment. 

Lead azide is insoluble in an aqueous solution of ammonia. Acetic acid causes its decomposition but it is soluble in water and concentrated solutions of sodium nitrate, sodium acetate or ammonium acetate. There are fairly big differences of solubility, depending on temperature. 

---