Senile dementia of Alzheimer’s type

Mishima K, Tozawa T, Satoh K, MatsumotoY, HishikawaY, Okawa M (1999) Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer s type with disturbed sleep-waking. Biol Psychiatry 45 417-421... 

Iversen LL, Rossor MN, Reynolds GP, Hills R, Roth M, Mountjoy CQ, Foote SL, Morrison JH, Bloom FE (1983) Loss of pigmented dopamine-beta-hydroxylase positive cells from locus coeruleus in senile dementia of Alzheimer s type. Neurosci. Lett. 39 95-100. 

Wilcock GK, Esiri MM, Bowen DM, Hughes AO (1988) The differential involvement of subcortical nuclei in senile dementia of Alzheimer s type. J. Neurol. Neurosurg. Psychiatry 51 842-849. 

Soderberg M., Edlund C., Alafuzoff 1. et al. Lipid composition in different regions of the brain in Alzheimer s disease/senile dementia of Alzheimer s type. J. Neurochem. 1992,5 1646-1653. 

By 1989, about 2000 individuals in the Minamata area have been officially certified to have Minamata Disease and eligible for financial compensation. Histopathologi-cal changes in brain were clearly linked to organomercury insult in Minamata Disease victims and the distribution of lesions in the nervous system was characteristic, especially in the cerebral cortices and the cerebellum. Pathological studies of 112 Minamata Disease victims also showed elevated frequencies of sepsis and malignant neoplasms of the thyroid gland when compared to 112 sex-age matched pair control deaths between 1970 and 1983 from various causes (senile dementia of Alzheimer s type, Parkinson s disease of idiopathic type, amyotrophic lateral sclerosis) in western parts of Japan. 

McCaddon, A., Davies, G., Hudson, P., Tandy, S., and Cattell, H., 1998. Total serum homocysteine in senile dementia of Alzheimer s type. International Journal of Geriatric Psychiatry. 13 235-239. 

Soderberg M, Edlund C, Alafuzoff I, Kristensson K, Dallner G. lipid composition in different regions of the brain in Alzheimer s disease/senile dementia of Alzheimer s type. J Neurochem. 1992 59(5) 1646-1653. Svennerholm L, Gottfries CG. Membrane Upids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (t)fpe I) and demyelinationin late-onset form (t)fpe II). / Neurochem. 

Other nootropic agents in some stage of clinical development include nebracetam (9), nefinacetam (10), and BMY 21502 (11). Nebracetam, an aminomethyl pyrrolidinone derivative, is expected to be approved in Japan in 1994 (73). In clinical studies involving patients having cerebrovascular or senile dementia of the Alzheimer s type, clinical symptoms such as spontaneous or emotional expression were enhanced in up to 71% of cases. Long-term treatment using nebracetam in patients with cerebral infarction also afforded marked improvement in most cases with few side effects (74). A review of this compound has beenpubUshed (75). 

The first neurochemical evidence of a disturbed serotonin function in cognition came from the changes in serotonin and/or 5-hydroxyindoleacetic acid (5-HIAA) levels in a number of forebrain nuclei, the temporal and cingulate cortex, hippocampus, and other areas of the brain taken at autopsy from patients with senile dementia of the Alzheimer s type (Adolfsson et al. 1978 Arai et al. 1984 D. M. Bowen et al. 1979, 1983 A. J. Cross et al. 1983 Winblad et al. 1982). The depletions are regionally selective reductions in se-... 

Similar results were obtained from material taken from patients with senile dementia of the Alzheimer s type (Chan-Palay et al. 1992). A loss of tryptophan hydroxylase immunoreactive neurons in the raphe nuclei, which was most pronounced in the lateral division, was correlated with both age and cortical pathology. Furthermore, tyrosine hydroxylase reactive neurons were also found to be reduced in the locus coeruleus, even more so than the tryptophan hydroxylase reactive neurons. The same was also found for material taken from brains with Parkinson s disease. 

Chan-Palay V, Asan E Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson s disease with and without dementia and depression. J Comp Neurol 287 373-392, 1989... 

Dysken MW, Mendels J, LeWitt P Milacemide a placebo-controlled study in senile dementia of the Alzheimer type. J Am Geriatr Soc 40 503-506, 1992 Dysken MW, Johnson SB, Holden L, et al Haloperidol concentrations in patients with Alzheimer s Disease. Am J Geriatr Psychiatry 2 124-133, 1994 Eagger SA, Levy R, Sahakian BJ Tacrine in Alzheimer s disease. Lancet 337 989-929, 1991... 

Hong J-S, Tilson HA, Yoshikawa K Effects of lithium and haloperidol administration on the rat brain levels of Substance P. J Pharmacol Exp Ther 224 590-597, 1983 Honig A, Bartlett JR, Bouras N, et al Amino acid levels in depression a preliminary investigation. J Psychiatr Res 22 159-164, 1989 Honjo H, Ogino Y, Natitoh K, et al In vivo effects by estrone sulphate on the central nervous system on senile dementia [Alzheimer s type). Journal of Steroid Biochemistry 34 521-525, 1989... 

Prince DA, Wilder BJ Cortical mechanisms in cortical epileptogenic foci surrounded inhibition. Arch Neurol 16 194-202, 1967 Prinz PN, Vitahano PP, Vitiello MV, et al Sleep, EEC and mental function changes in senile dementia of the Alzheimer s type. Neurobiol Aging 3 361-370, 1982... 

Chatellier G, Lacomblez L Tacrine (tetrahydroaminoacridine THA) and lecithin in senile dementia of the Alzheimer s type a multicentre trial. Groupe Fran(jais d Etude de la Tetrahydroaminoacridine. BMJ 300 495-499, 1990... 

Wettstein, A., Spiegel, R. Clinical trials with the cholinergic drug RS 86 in Alzheimer s disease (AD) and senile dementia of the Alzheimer type (SDAT). Psychopharmacology 84, 572-573, 1984. 

Brain Studies. Rubidium-82 has also been used to study blood brain barrier changes in patients with brain tumors or Alzheimer s type senile dementia (28-30). The method of study is similar to the heart studies without gating. Figure 11 shows the uptake of Rb-82 in the three levels of a brain tumor. This non-invasive procedure provides information on the size and vascularity of the tumor. In the slice OM + 10 there is a vascular rim and a necrotic center in the tumor. The metabolism of glucose was determined in the same tumor patient using F-fluorodeoxyglucose produced on a cyclotron and the results correlated well with Rb-82 distribution. 

Senile dementia of the Alzheimer s type Standard Error Single European Act of 1987... 

Clinical trial in senile dementia of the Alzheimer s type B. Reisberg et at, N, Engl J. Med. 308, 721 (1983). Review of role in rehabilitation of opiate addicts A. Schec-ter, Am, J. Drug Alcohol Abuse 7, 1-18 (1980) of preclinical research A. L. Misra, Nat. Inst. Drug Abuse Res. Mono-... 

An indirect preventive role for silicon has been suggested in senile dementia of the Alzheimer type. This notion was deduced from the silicon s ability to reduce the absorption of aluminum through formation of insoluble hydroxyaluminosilicates in the gastrointestinal tract (Birchall and Chappell 1989, Edwardson et al. 1993). 

Boiler, F. (1985) Parkinson s disease and Alzheimer s disease are they associated In J.T. Hutton and A.D. Kenny (Eds.), Senile Dementia of the Alzheimer Type, A.R. Liss, New York, pp. 119-129. 

Controlled studies demonstrate improvement in mild to moderate symptoms of memory loss, depression, and disorientation associated with CNS vascular deficiency or Senile Dementia of the Alzheimer"s Type (SDAT) in elderly populations. 

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